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Nicotinamide Riboside

Author: Dr. George Shanlikian, M.D.  |   Last Updated: November 20th, 2024

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Overall Health Benefits of Nicotinamide Riboside

  • Extends lifespan [1-15]
  • Produces anti-aging effects [16-23]
  • Improves exercise performance [13, 22-26]
  • Promotes weight loss [25, 27-36]
  • Increases muscle mass and strength [13, 15, 17, 22, 37-40]
  • Boosts cognitive health [41-58]
  • Lowers the risk of cardiovascular disease [29, 59-71]
  • Prevents cancer and treats side effects of chemotherapy [72-83]
  • Lowers blood pressure [84-85]
  • Improves symptoms of diabetes and lowers blood sugar levels [86-91]
  • Lowers the risk of stroke and improves recovery [92-97]
  • Improves kidney function [98-102]
  • Improves eye health [103-109]

Key Takeaways

  • Boosts NAD+ Levels: Nicotinamide Riboside is a form of vitamin B3 that helps increase NAD+ (nicotinamide adenine dinucleotide) levels in cells, which is vital for energy production and cellular metabolism.
  • Supports Healthy Aging: By enhancing NAD+ levels, NR may promote healthy aging by supporting cellular repair mechanisms, improving mitochondrial function, and protecting against age-related diseases.
  • Potential Cognitive Benefits: NR is being studied for its potential neuroprotective effects, which may improve cognitive function and reduce the risk of neurodegenerative diseases like Alzheimer’s.
  • Enhances Metabolic Health: Research suggests that NR supplementation could improve metabolism, support healthy weight management, and enhance insulin sensitivity.
  • Safe and Well-Tolerated: NR supplements are generally considered safe with minimal side effects, making them a popular option for those seeking to boost NAD+ levels and support overall health.

What is Nicotinamide Riboside?

How Nicotinamide Riboside Works
Also known as niagen, nicotinamide riboside (NR) is an alternative form of vitamin B3. It exerts its anti-aging effects when the body converts it into nicotinamide adenine dinucleotide (NAD+), a helper molecule (coenzyme) that is present in all living cells. NAD+ is essential for several important biological processes including the conversion of food into energy, DNA repair, regulation of immune function, and regulation of the body’s internal clock. Boosting NAD+ levels in the body has been shown to produce several health benefits. [1] Nicotinamide riboside can be found in small amounts in fruits, vegetables, meat, and milk.

How Nicotinamide Riboside Works

Extends Lifespan

The conversion of nicotinamide riboside into nicotinamide adenine dinucleotide (NAD+) allows the body to perform various important biological processes. This includes energy production from food, DNA repair, regulation of immune function, and regulation of the body’s internal clock.

Chemical Structure of Nicotinamide Riboside

Nicotinamide Riboside

Research on Nicotinamide Riboside

A. Extends Lifespan

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Nicotinamide riboside is converted by the body into nicotinamide adenine dinucleotide (NAD+), a helper molecule (coenzyme) that is present in all living cells and is essential for a broad range of biological functions. To put it simply, nicotinamide riboside is required in order to boost the levels of NAD+ in the body. Studies show that increased NAD+ levels are associated with a longer lifespan. [1-5] This suggests that boosting NAD+ levels through nicotinamide riboside supplementation may help extend lifespan.

Another mechanism that is known to extend lifespan is through increasing sirtuin (SIRT) activity. Increased SIRT activity has been shown to stabilize telomeres (located at chromosomes ends) and attenuate age-related telomere shortening. [6] Interestingly, studies found that individuals with longer telomeres have a longer subsequent lifespan. [7-8] With increased SIRT1 activity, the telomeres are more stable and their length increases which in turn extends lifespan

Nicotinamide riboside-mediated increase in NAD+ activates SIRT1, an enzyme that plays an integral role in the regulation of proteins involved in cellular metabolism and processes associated with longevity, inflammation, and stress. SIRT1 activation removes acetyl groups from transcriptional regulators such as FOXO1 (Forkhead box protein O1) and PGC-1alpha (Peroxisome proliferator-activated receptor-gamma coactivator). This in turn causes metabolic adaptation, a survival mechanism that decreases the resting metabolic rate (number of calories burned at rest). As a result, cells undergo a process called mitochondrial biogenesis, which involves the production of new mitochondria (the powerhouse of cells). Mitochondrial biogenesis is critical for increased longevity since mitochondrial dysfunction in cells is associated with various age-related diseases and a shorter lifespan. [9-10]

A number of studies support that nicotinamide riboside can positively affect longevity mechanisms:

  1. In human and mice subjects with telomere disease, supplementation with the NAD precursor, nicotinamide riboside, improved NAD homeostasis, which in turn alleviated damage to the telomeres, defective mitochondrial biosynthesis and clearance, cell growth retardation, and cellular senescence. [11]
  2. In mice, nicotinamide riboside improved gene function and extended the lifespan without calorie restriction. [12]
  3. In a mouse model of muscular dystrophy, a condition characterized by the gradual weakening of the muscles, treatment with the NAD+ precursor nicotinamide riboside delayed muscle breakdown and increased lifespan. [13]
  4. In mice, nicotinamide riboside supplementation increased lifespan by protecting against high-fat diet-induced metabolic abnormalities and activating SIRT1 and SIRT3. [14-15

B. Produces Anti-Aging Effects

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Nicotinamide riboside-mediated increase in NAD+ levels can slow down the signs of aging by preventing mitochondrial dysfunction, which contributes to cellular senescence (also known as biological aging), increased inflammation, decreased stem cell activity, reduced healing rate, and a decline in tissue and organ function. [16] By activating SIRT1, new and healthy mitochondria are formed through a process called mitochondrial biogenesis.

An increasing number of evidence supports the anti-aging effects of nicotinamide riboside:

  1. In mice with mitochondrial dysfunction, oral administration of nicotinamide riboside increased mitochondrial numbers and prevented muscle abnormalities. [17]
  2. In mice, the administration of nicotinamide riboside prevented noise-induced hearing loss and degeneration of ear cells, suggesting that increasing NAD+ levels can help age-related hearing loss. [18]
  3. In a mouse model of amyotrophic lateral sclerosis (ALS), which is characterized by progressive degeneration of motor neurons, nicotinamide riboside supplementation delayed motor neuron degeneration and decreased markers of neuroinflammation in the spinal cord. [19]
  4. In aged men, nicotinamide riboside supplementation at 1 gram per day for 21 days increased NAD+ levels and decreased the levels of circulating inflammatory cytokines in the aged muscle. [20]
  5. The use of NAD+ precursors such as nicotinamide riboside has been proposed as a strategy for improving age-related decline physiological functions. [21]
  6. In aged mice, nicotinamide riboside rapidly ameliorated the aging-triggered muscle degeneration resulting in increased strength and endurance. [22]
  7. A study reported that nicotinamide riboside can play an important role in anti-aging therapy in humans, especially in the face skin anti-aging treatment. [23]

C. Improves Exercise Performance

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NAD+ plays an integral role in energy production and regulation of a broad range of biological processes. One of the most important functions of NAD+ is generating a usable form of energy called adenosine triphosphate (ATP). By boosting NAD+ levels, nicotinamide riboside can also help increase energy levels which can improve exercise performance.

Studies suggest that nicotinamide riboside supplementation can help improve exercise performance:

  1. In a mouse model of muscular dystrophy, a condition characterized by the gradual weakening of the muscles, treatment with nicotinamide riboside increased maximal running times and distances. [13]
  2. In aged mice, nicotinamide riboside rapidly ameliorated the aging-triggered muscle degeneration which in turn prevented the development of exercise intolerance. [22]
  3. Nicotinamide riboside supplementation decreased oxidative stress and improved physical performance in older men (evidenced by improved scores in the fatigue index) compared to younger men. [24]
  4. In mice, nicotinamide riboside supplementation increased endurance performance. [25]
  5. In mice with heart and muscle weakness caused by adenine nucleotide translocator isoform 1 (ANT1) deficiency, nicotinamide riboside alleviated exercise intolerance. [26]

D. Promotes Weight Loss

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Nicotinamide riboside boosts NAD+ levels which in turn increases energy expenditure. As a result, the body does not store additional fat. Moreover, evidence suggests that increased NAD+ levels are associated with increased metabolism. [27] All of these mechanisms can help promote weight loss.

The fat-burning properties of nicotinamide riboside are backed by a number of studies:

  1. In mice, nicotinamide riboside protected against high-fat diet-induced obesity by enhancing oxidative metabolism. [25]
  2. In obese men and women, the administration of nicotinamide riboside at a dose of 1 gram per day for 6 weeks was associated with a reduction in the percentage of fat mass. [28]
  3. In obese rats, treatment with nicotinamide riboside alone mitigated final body weight gain and reduced adiposity (visceral and subcutaneous). [29]
  4. In mice fed with a high-fat diet, nicotinamide riboside treatment was sufficient to deflect weight gain by increasing energy expenditure. [30]
  5. In obese rats under calorie restriction, nicotinamide riboside supplementation (400 mg/kg) for 4 weeks enhanced weight loss without altering muscle mass. [31]
  6. Obese female mice fed with nicotinamide riboside had significantly reduced body weight gain and fat mass and increased metabolic rates, physical activity, and energy expenditure compared with mice fed with a high-fat/high-sucrose/high-cholesterol diet. [32]
  7. Nicotinamide riboside supplementation in female mice enhanced postpartum weight loss and increased lactation and nursing behaviors. [33]
  8. In mice on a moderate-fat diet, nicotinamide riboside supplementation at 30 mg/kg per diet increased the activity of peroxisome proliferators–activated receptor γ (PPARγ), a master regulator of fat cell formation. [34]
  9. In mice, nicotinamide riboside protected against high-fat diet-induced metabolic abnormalities by activating SIRT1 and SIRT3. [35]
  10. In mice, nicotinamide riboside supplementation at 400 mg/kg/day for 5 weeks reduced the abdominal visceral fat depots. [36]

E. Increases Muscle Mass and Strength

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By boosting NAD+ levels, nicotinamide riboside can help attenuate the age-related decline in muscle mass and strength. This is because increased NAD+ levels are associated with enhanced ATP production and mitochondrial function and reduced muscle inflammation. [37] In addition, NAD+ is found to be a major player in skeletal muscle development and regeneration. [38]

Studies suggest that nicotinamide riboside can help prevent muscle degeneration and improve muscle health:

  1. In a mouse model of muscular dystrophy, a condition characterized by the gradual weakening of the muscles, treatment with nicotinamide riboside delayed muscle breakdown. [13, 15]
  1. In mice with mitochondrial dysfunction, oral administration of nicotinamide riboside prevented muscle abnormalities by increasing mitochondrial numbers. [17]
  2. In aged mice, nicotinamide riboside rapidly ameliorated the aging-triggered muscle degeneration. [22]
  3. In overweight and obese patients, nicotinamide riboside supplementation increased skeletal muscle and induced minor changes in body composition. [39]
  4. In healthy overweight or obese men and women, nicotinamide riboside supplementation at 1000 mg per day for 6 weeks increased muscle mass. [40]

F. Boosts Cognitive Health

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The ability of nicotinamide riboside to improve cognitive function can be attributed to its NAD+-boosting properties. NAD+ can help protect against brain disorders by decreasing the production of reactive oxygen species (ROS), which are linked to a wide array of medical maladies including neurodegenerative diseases. [41] NAD+ can also help prevent degeneration of nerve cells in the brain by regulating the activity of poly adenosine diphosphate-ribose polymerase 1 (PARP1). [42-43] Another mechanism that is important in boosting cognitive health is the ability of NAD+ to regulate the production of brain chemicals called neurotransmitters, such as dopamine, serotonin, and norepinephrine. These brain chemicals play an integral role in different cognitive functions such as memory, motivation, attention, mood, and emotions.

Studies show that nicotinamide riboside can be a therapeutic strategy in improving brain health:

  1. A study showed that nicotinamide riboside supplementation protected brain neurons (nerve cells) from traumatic injury. [44]
  2. In a mouse model of Alzheimer’s disease, nicotinamide riboside treatment restored cognitive function by preventing the production of abnormal protein structures in the brain called beta-amyloid, attenuating DNA damage, and decreasing neuroinflammation. [45-51]
  3. In diabetic mice fed with a high-fat diet, nicotinamide riboside improved cognitive function and reduced brain inflammation by decreasing the levels of abnormal protein structures. [52]
  4. In a patient with Parkinson’s disease, nicotinamide riboside ameliorated the loss of nerve cells in the brain and decline in motor function. [53]
  5. In mice with decreased short-term memory function, the addition of nicotinamide riboside into the food of the subjects for 28 days alleviated cerebral small vessel disease (CSVD) by protecting the brain integrity and preventing neuroinflammation. [54]
  6. In mice with mild cognitive impairment, nicotinamide riboside treatment for 10 weeks improved blood flow to the brain. [55]
  7. A latest review of multiple studies found that oral nicotinamide riboside supplementation has been shown to be successful in multiple preclinical models of neurodegeneration and brain function. [56]
  8. In mice with brain injury due to insufficient blood flow, nicotinamide riboside treatment reduced the loss of brain nerve cells and ultimately promoted the recovery of cognitive function. [57]
  9. A study reported that nicotinamide riboside can protect against the degeneration of nerve cells in the brain. [58]

G. Lowers the Risk of Cardiovascular Disease

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Nicotinamide riboside-mediated increase in NAD+ levels can help promote normal heart function and enhanced cardiac recovery from injury. It has been shown that NAD+ activates SIRT3 which is associated with the prevention of heart enlargement and scarring. [59-61] Moreover, the mitochondrial conservation effects of NAD+ are known to play an integral role in inhibiting heart failure. [62]

Studies show that nicotinamide riboside can help protect against heart disease:

  1. In obese Wistar rats under caloric restriction, nicotinamide riboside reduced cardiometabolic risk factors by modulating cardiac oxidative stress. [29]
  2. In obese rats, nicotinamide riboside supplementation increased antioxidant capacity which in turn reduced the risk of cardiovascular disease. [63]
  3. In a mouse model of dilated cardiomyopathy, nicotinamide riboside preserved cardiac function. [64]
  4. A study showed that modulating NAD+ levels through nicotinamide riboside supplementation can help prevent heart disease. [65]
  5. In mice with heart dysfunction, nicotinamide riboside reduced the levels of inflammatory cytokines and alleviated oxidative stress, heart enlargement, and cardiac dysfunction. [66]
  6. In patients with heart failure with preserved ejection fraction, nicotinamide riboside improved heart function and lowered the risk of related deaths. [67]
  7. In mice with heart injury due to insufficient blood flow, nicotinamide riboside suppressed scarring of the heart muscle and prevented the death of cardiac cells. [68]
  8. In mice with chronic pressure overload in the heart, nicotinamide riboside protected against cardiac dysfunction and prevented heart enlargement. [69]
  9. In mice receiving chemotherapy, nicotinamide riboside prevented doxorubicin-induced cardiotoxicity. [70]
  10. In diabetic mice, nicotinamide riboside promoted mitochondrial fusion which in turn reduced the death of heart cells. [71]

H. Prevents Cancer and Treats Side Effects of Chemotherapy

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Cancer cells usually exhibit mitochondrial respiration malfunction and increased glucose uptake – both of these mechanisms can be prevented by increasing NAD+ levels. [72] In addition, increased NAD+ levels are known to boost the activity of SIRT1 and SIRT6, both of which are known to exert anti-tumor effects. [73-74] This suggests that nicotinamide riboside-mediated increase in NAD+ levels can help inhibit cancer growth.

The anti-cancer properties of nicotinamide riboside and its ability to treat the side effects of chemotherapy are backed by a number of studies:

  1. A study showed that nicotinamide riboside has the potential to be used in cancer prevention and therapy. [75]
  2. A study also showed that nicotinamide riboside can be a promising approach for skin cancer prevention. [76]
  3. A study reported that nicotinamide riboside can inhibit the growth of cancer cells via SIRT1 activation. [77]
  4. In mice with cancer of the mucus-secreting gland cells, nicotinamide riboside mitigated muscle wasting associated with the disease. [78]
  5. In tumor-bearing rats, once daily oral administration of 200 mg/kg nicotinamide riboside relieved peripheral neuropathy (nerve damage) caused by the chemotherapeutic drug paclitaxel and enhanced the suppression of tumor growth. [79-80]
  6. In immune-deficient mice receiving cancer therapy, nicotinamide riboside improved survival by 80% and increased the production of immune system cells. [81]
  7. In a mouse model of lung cancer, nicotinamide riboside alleviated nerve damage caused by the chemotherapeutic drug cisplatin via SIRT2 activation. [82]
  8. In animal models of cancer, nicotinamide riboside administration prevented heart muscle injury caused by the chemotherapeutic drug doxorubicin. [83]

I. Lowers Blood Pressure

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Nicotinamide riboside can also be beneficial in people with hypertension because of its blood pressure-lowering effects. By boosting NAD+ levels, SIRT1 activation occurs which in turn increases the production of nitric oxide, a substance that helps widen blood vessels (vasodilation) to allow an increase in blood flow. This process reduces the pressure within the blood vessels.

Studies report that nicotinamide riboside has anti-hypertensive properties:

  1. In healthy, middle-aged-older adults, nicotinamide riboside supplementation reduced blood pressure and increased NAD+ levels. [84]
  2. In hypertensive rats, nicotinamide riboside supplementation prevented age-related increase in blood pressure. [85]

J. Improves Symptoms of Diabetes and Lowers Blood Sugar Levels

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Nicotinamide riboside can also benefit people suffering from the unpleasant symptoms of diabetes and high blood sugar levels. It does this by boosting the levels of NAD+ which in turn enhances the body’s response to the blood sugar-lowering effects of the hormone insulin.

Evidence shows that nicotinamide riboside has anti-diabetic effects:

  1. In mice with type 2 diabetes, nicotinamide riboside supplementation prevented the development of type 2 diabetes and nerve damage. [86]
  2. In mice, a high dose of dietary nicotinamide riboside prevented blood sugar intolerance. [87]
  1. In overweight and obese patients, nicotinamide riboside supplementation increased skeletal muscle and induced minor changes in body composition and blood sugar. [88]
  2. In a rodent model of obesity and type 2 diabetes, nicotinamide riboside improved blood sugar metabolism by correcting insulin resistance. [89]
  3. In a rodent model of type 2 diabetes, nicotinamide riboside ameliorated liver inflammation. [90]
  4. In mice with type 2 diabetes and severe insulin resistance, nicotinamide riboside greatly reduced non-fasting and fasting blood glucose, weight gain, and fat deposition in the liver while protecting against diabetic neuropathy (nerve damage). [91]

K. Lowers the Risk of Stroke and Improves Recovery

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NAD+ is essential for brain health and may help protect against various brain injuries. Stroke is a condition wherein the blood supply to the brain is cut off or a blood vessel ruptures. NAD+ is known to improve blood circulation to the brain – a mechanism that may help prevent stroke. Since nicotinamide riboside boosts NAD+ levels, it may offer protective effects against stroke.

A good deal of evidence shows that nicotinamide riboside can help lower the risk of stroke and improve recovery through different mechanisms:

  1. Studies found that nicotinamide riboside lowers the risk of stroke by protecting the nerve cells in the brain against various forms of injury or damage. [92-94]
  2. In wild-type mice, nicotinamide riboside supplementation improved the recovery of the subjects from ischemic stroke (caused by inadequate blood supply). [95]
  3. A study showed that nicotinamide riboside can be a therapeutic intervention for stroke rehabilitation. [96]
  4. A study also showed that nicotinamide riboside has the capacity to restore the formation of new brain neurons, suggesting that it can help address the loss of neurons due to stroke. [97]

In acute kidney injury, substantial decreases in NAD+ levels are known to impair energy generation and affect the core function of the kidney. [98] In addition, decreased NAD+ levels also decrease sirtuin activity which contributes to the decline in kidney function. Thus, augmentation of NAD+ through nicotinamide riboside supplementation may help protect the kidneys and improve their health.

Nicotinamide riboside has been shown to play an essential role in maintaining optimal kidney function:

  1. A study showed that nicotinamide riboside can help prevent the development of kidney disease by increasing NAD+ levels and sirtuin activity. [99]
  2. A study found that boosting NAD+ levels via nicotinamide riboside administration ameliorated experimental kidney injury caused by inadequate blood flow. [100]
  3. In dialysis patients, nicotinamide riboside supplementation reduced complications such as elevated phosphate levels. [101]
  4. A study demonstrated that NAD+ precursors such as nicotinamide riboside may attenuate acute kidney injury by reducing oxidative stress and inflammation. [102]

M. Improves Eye Health

Nicotinamide riboside-mediated increase in NAD+ can also help protect against various eye disorders including the age-related decline in visual function. The modulation of sirtuin activity by NAD+ enhances retinal metabolism, reduces the death of eye cells, and improves vision. [103]

A number of convincing pieces of evidence suggest that nicotinamide riboside can help improve eye health:

  1. In two mouse models of retinal ganglion cell damage, systemic treatment with nicotinamide riboside suppressed retinal inflammation. [104-105]
  2. In a mouse model of light-induced retinal degeneration, nicotinamide riboside injections the day before and the morning of exposure to degeneration-inducing levels of light prevented programmed cell death and inflammation in the outer retina. [106]
  3. In hydrogen peroxide-exposed human lens epithelial cell lines, nicotinamide riboside alleviated oxidative damage by targeting the MAPK and JAK2/Stat3 pathways. [107]
  4. Preclinical studies suggest that nicotinamide riboside can be an effective therapeutic option to slow optic nerve degeneration in patients with primary open-angle glaucoma (POAG). [108-109]

Nicotinamide Riboside Side Effects

Nicotinamide riboside side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on nicotinamide riboside. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of nicotinamide riboside. Despite this, it was listed as a side effect associated with nicotinamide riboside even though these associated side effects are very uncommon.

Side effects associated with nicotinamide riboside may include the following:

  • Bloating
  • Diarrhea
  • Fatigue
  • Headache
  • Indigestion
  • Itching
  • Nausea
  • Sweating

What is Nicotinamide Riboside Supplement?

Nicotinamide riboside (NR) is a form of vitamin B3 that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical molecule involved in cellular energy production and various metabolic processes. NAD+ levels naturally decline with age, and this decrease is associated with aging and various health conditions. NR supplements are designed to increase NAD+ levels, potentially supporting cellular health, energy metabolism, and overall vitality.

Research suggests that boosting NAD+ through NR supplementation may have several health benefits, including improved mitochondrial function, enhanced cognitive performance, and possibly extending lifespan. Some studies have also explored its potential in protecting against neurodegenerative diseases like Alzheimer’s and Parkinson’s by supporting cellular repair mechanisms and reducing oxidative stress.

Despite these promising findings, the effectiveness and long-term safety of NR supplements are still under investigation. While some people report feeling more energized or noticing improvements in their skin and overall well-being, others experience minimal effects. As with any supplement, it is advisable to consult a healthcare professional before starting NR, especially for those with underlying health conditions.

Nicotinamide Riboside Supplementation

Nicotinamide riboside (NR) supplementation has gained attention for its potential role in enhancing cellular health and supporting healthy aging. NR is a form of vitamin B3 and a precursor to NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme involved in energy production, DNA repair, and cellular metabolism. As we age, NAD+ levels naturally decline, leading to reduced cellular function and increased susceptibility to age-related diseases. Supplementing with NR has been shown to effectively raise NAD+ levels, which may improve mitochondrial function, enhance cognitive health, and promote longevity.

The benefits of NR supplementation extend beyond aging, with research suggesting potential improvements in metabolic health. By increasing NAD+ levels, NR may enhance insulin sensitivity, support weight management, and reduce inflammation. Early studies also indicate that NR could offer neuroprotective effects, making it a promising supplement for those looking to protect against neurodegenerative conditions like Alzheimer’s disease. Additionally, NR is generally well-tolerated, with minimal side effects reported in most clinical trials.

While the long-term effects of NR supplementation are still being studied, the current research is encouraging. Individuals interested in boosting cellular energy, supporting cognitive health, or improving metabolic function may consider NR as a valuable addition to their supplement routine. However, as with any supplement, it’s important to consult with a healthcare provider before beginning NR supplementation, especially for those with existing health conditions or those taking other medications.

What is Nicotinamide Riboside Chloride?

Nicotinamide Riboside Chloride (NR) is a form of vitamin B3 that acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular metabolism. NAD+ plays a vital role in energy production, DNA repair, and cellular aging. By supplementing with NR, it is believed that one can boost NAD+ levels, potentially enhancing overall cellular function and vitality.

In recent years, NR has gained attention for its potential benefits in age-related health issues and metabolic conditions. Research suggests that increasing NAD+ levels through NR supplementation may support healthy aging, improve metabolic function, and even enhance cognitive performance. However, while preliminary studies are promising, more research is needed to fully understand its long-term effects and benefits.

Nicotinamide Riboside Chloride is available in various dietary supplements and is generally considered safe when used as directed. However, it’s essential to consult with a healthcare provider before starting any new supplement regimen, particularly if you have underlying health conditions or are taking other medications.

Nicotinamide Riboside Powder

Nicotinamide Riboside (NR) powder is a form of Vitamin B3 that has garnered attention for its potential health benefits. As a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular metabolism, NR is believed to support various physiological processes. NAD+ is essential for energy production, DNA repair, and cellular maintenance, and its levels tend to decline with age. By supplementing with NR, individuals may aim to boost NAD+ levels and potentially improve overall metabolic health.

Research into Nicotinamide Riboside has suggested several promising benefits. Studies indicate that NR supplementation may enhance mitochondrial function, which can positively affect energy levels and endurance. Additionally, it may have a role in improving cognitive function and promoting healthy aging. Some preliminary research also suggests that NR could have protective effects against age-related diseases, although more extensive human studies are needed to fully understand its long-term impact.

Despite the promising aspects of NR powder, it’s essential to approach supplementation with caution. The effectiveness and safety of NR can vary among individuals, and the long-term effects are still under investigation. Consulting with a healthcare provider before starting any new supplement regimen is advisable, especially for those with underlying health conditions or those taking other medications.

Nicotinamide Riboside vs NMN

Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are both compounds involved in the production of NAD+, a vital molecule for cellular metabolism and energy production. NR is a precursor to NAD+ and is converted into NMN before ultimately being converted into NAD+. Studies have shown that NR supplementation can effectively increase NAD+ levels in the body, potentially offering benefits such as improved mitochondrial function and enhanced cellular repair mechanisms.

NMN, on the other hand, is a direct precursor to NAD+ and is considered to be closer to the final product in the NAD+ biosynthesis pathway. Research suggests that NMN supplementation may offer similar benefits to NR, such as improved metabolic health and potential anti-aging effects. Some studies have indicated that NMN might have a more immediate effect on NAD+ levels due to its direct role in the biosynthesis pathway.

Both NR and NMN have shown promise in preclinical and early clinical studies for their potential to improve various aspects of health, including metabolism, cardiovascular health, and age-related conditions. However, more research is needed to fully understand their long-term effects and optimal dosages. Choosing between NR and NMN often depends on individual health goals and preferences, as both offer valuable benefits in supporting NAD+ levels and overall well-being.

Nicotinamide Riboside Dosage

Nicotinamide riboside (NR) is a popular supplement known for its potential to boost cellular NAD+ levels, which can support various aspects of cellular health and longevity. The dosage of NR can vary depending on individual health goals and specific formulations. Typically, daily doses range from 250 mg to 300 mg. Research suggests that this amount is effective in raising NAD+ levels without significant side effects.

For individuals seeking general health benefits or age-related support, a daily dosage of 300 mg is commonly recommended. This dosage is often used in clinical studies and has been shown to enhance NAD+ levels, which may help with cellular repair and metabolic function. However, some users may start with a lower dose, such as 250 mg, to assess tolerance before increasing to the higher end of the spectrum.

It’s important to consult with a healthcare professional before starting nicotinamide riboside supplementation, especially if you have underlying health conditions or are taking other medications. Personal needs and responses can vary, so a tailored approach is often the best way to determine the most appropriate dosage for individual health goals.

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FAQ

Is vitamin B3 the same as nicotinamide riboside?

Nicotinamide riboside (NR) is a form of vitamin B3, but not all forms of vitamin B3 are the same. Other forms include niacin and nicotinamide. Taking nicotinamide riboside (NR) is a unique precursor to NAD+. Nicotinamide riboside is particularly notable for its potential benefits. Taking nicotinamide riboside can help support cellular health by boosting NAD+ levels.

What is the best food source of nicotinamide riboside?

Nicotinamide riboside is found in small amounts in foods like milk, fish, and yeast, but the levels are very low compared to supplements. However, clinical testing has shown that supplements can provide much higher and more effective doses. Researchers are conducting more clinical testing to determine its potential benefits for various health conditions. Ongoing clinical testing will help establish the safest and most beneficial dosage for daily intake.

How much nicotinamide riboside is safe?

Studies typically suggest that doses up to 300 mg per day of endogenous nr are safe for most healthy overweight adults, though higher doses of endogenous nr have been used in research with few side effects. It is important to note that the safety of endogenous nr at higher doses continues to be evaluated, especially in healthy overweight adults. Ongoing research aims to determine the long-term effects of higher doses on healthy overweight adults and other populations.

Is NR worth taking?

NR chloride may be worth taking for those interested in supporting cellular energy, healthy aging, and overall metabolic health. However, more research, including molecular evaluation, is needed to fully validate its benefits. Molecular evaluation can help clarify the precise mechanisms through which NR chloride impacts cellular functions. Continued studies and molecular evaluation are essential to understand its potential fully with NR chloride.

What is nicotinamide riboside good for?

Nicotinamide riboside is primarily known for boosting NAD+ levels, which can enhance cellular repair, improve mitochondrial function, support cognitive health, and potentially slow aging processes. The benefits have been explored in double-blind, placebo-controlled studies, demonstrating its potential. Further double-blind, placebo-controlled research could help validate its effectiveness in slowing aging. Overall, double-blind, placebo-controlled trials are essential for confirming these effects.

What is the best brand of nicotinamide riboside?

Popular brands include Tru Niagen and Elysium Basis, both of which offer high-quality, third-party tested NR supplements. Both products have been evaluated in placebo-controlled clinical trials, ensuring their effectiveness and safety. In fact, when considering NR supplements, it’s crucial to choose brands that have undergone rigorous testing in placebo-controlled clinical trials. Tru Niagen and Elysium Basis are both known for adhering to these standards, highlighting the importance of selecting supplements that are supported by placebo-controlled clinical trials.

Are there any dangers taking NAD supplements?

NAD supplements like NR are generally considered safe, but some individuals may experience mild side effects like nausea, fatigue, headaches, or high blood pressure. Long-term safety is still under study, especially for those with high blood pressure. It’s advisable to consult a healthcare provider if you have concerns about potential interactions with conditions like high blood pressure.

Should I take nicotinamide riboside?

Taking NR could be beneficial if you are interested in supporting healthy aging, improving metabolic health, or boosting energy levels. In the field of biochemical sciences, NR is often discussed for its potential benefits in cellular energy production and longevity. However, consult with a healthcare provider to determine if it’s right for you, as the application of biochemical sciences to individual health requires personalized advice. For those involved in biochemical sciences, understanding the mechanisms of NR can be key to exploring its therapeutic potential.

What food contains nicotinamide riboside?

Foods like milk, fish, and yeast naturally contain small amounts of nicotinamide riboside. A placebo-controlled clinical trial might examine the benefits of these foods in boosting NAD+ levels and their potential impact on blood lipids. Understanding the effects through a placebo-controlled clinical trial could be crucial in determining their role in health, particularly concerning blood lipids. Finally, more research, especially via a placebo-controlled clinical trial, could further validate these findings and their implications for blood lipids.

What is nicotinamide riboside chloride used for?

Nicotinamide riboside chloride is used as a supplement to increase NAD+ levels, supporting cellular energy, metabolism, and potentially healthy aging. Being orally bioavailable, nicotinamide riboside chloride influences biosynthetic pathways to help enhance these processes. The compound, which is orally bioavailable, plays a role in various biosynthetic pathways, contributing to overall cellular health and longevity.

Does nicotinamide riboside really work?

Research shows that nicotinamide riboside, a dietary supplement, effectively increases NAD+ levels, and early studies suggest benefits in areas like nature metabolism, cognitive function, and blood nad lipids. However, more long-term studies on this dietary supplement and its impact on nature metabolism and blood nad lipids are needed. Overall, the potential of this dietary supplement in relation to nature metabolism, blood nad, and blood lipids remains promising but requires further investigation.

Is NAD just vitamin B3?

No, NAD is not vitamin B3; it’s a molecule derived from vitamin B3 (including forms like NR) that plays a crucial role in energy production and cellular processes. The human oral availability of NAD precursors, such as NR, is essential for their clinical efficacy in boosting NAD levels. Understanding the human oral availability of these supplements is key to evaluating their clinical efficacy and potential benefits. Moreover, research continues to explore how enhancing NAD through human oral availability could impact health and aging, contributing to our understanding of their clinical efficacy.

Is nicotinamide riboside chloride NMN?

No, nicotinic acid riboside and NMN (nicotinamide mononucleotide) are different compounds, though both are precursors to NAD+. The observed adverse effect level of nicotinic acid riboside and NMN may vary due to their distinct properties, especially when studied in animal models. Understanding the observed adverse effect level for each nicotinic acid riboside through research involving animal models can help in determining safe usage guidelines. Animal models are essential for gaining insights into the potential risks and benefits of these compounds before human application.

What are nicotinamide riboside benefits?

NR’s benefits include increasing NAD+ levels and related metabolites, supporting cellular energy production, improving mitochondrial function, promoting healthy aging, and potentially enhancing cognitive health. By boosting NAD+ levels and related metabolites, NR may also contribute to maintaining healthy systolic blood pressure. Furthermore, improving mitochondrial function with NR and related metabolites can help in managing systolic blood pressure levels effectively.

Is it safe to take nicotinamide riboside?

Yes, NR is generally considered safe for most people when taken at recommended doses, though consulting with a healthcare provider is advised. Hematopoietic stem cell regeneration can be an important consideration in discussions about overall health. It’s also beneficial to explore how hematopoietic stem cell regeneration might interact with NR supplementation. A placebo-controlled clinical trial could provide valuable insights into these interactions. Additionally, another placebo-controlled clinical trial focusing on hematopoietic stem cell regeneration and NR supplementation might offer clearer understanding. Evaluating results from a placebo-controlled clinical trial would help guide recommendations on NR’s safety and efficacy.

Who should not take nicotinamide?

Individuals with certain health conditions, those taking specific medications, or those with allergies to niacin-related compounds should consult with a doctor before taking nicotinamide or NR, as highlighted in six clinical trials. This is particularly important for those who have conditions affecting peripheral blood mononuclear cells, which have been studied in six clinical trials. Additionally, since peripheral blood mononuclear cells can be influenced by various treatments, it is crucial to discuss any potential interactions with your healthcare provider, as noted in six clinical trials. Ensuring that peripheral blood mononuclear cells are not adversely affected will help in managing overall health effectively.

What is NR powder used for?

NR powder is used as a supplement to increase NAD+ levels, potentially benefiting energy metabolism, cellular health, and aging. Dietary intake of NR powder can play a role in improving NAD+ levels, which helps mitigate the effects of metabolic stress on cellular functions. This dietary intake can be particularly beneficial in reducing the impact of metabolic stress associated with aging and other health conditions. By focusing on proper dietary intake, users can enhance the effectiveness of NR powder in supporting overall cellular health.

Is nicotinamide riboside better than NMN?

Both nutritional supplement nicotinamide riboside (NR) and NMN are effective at increasing NAD+ levels, but nutritional supplement nicotinamide riboside (NR) has more research supporting its safety and effectiveness in humans. The choice often depends on individual preferences and goals, and nutritional supplement nicotinamide riboside (NR) is frequently recommended for those seeking a well-researched option. Additionally, nutritional supplement nicotinamide riboside (NR) offers a viable alternative to NMN, especially for those interested in the benefits of nutritional supplement nicotinamide riboside (NR) based on current evidence.

Is it better to take NMN or NR?

Both NMN and NR are effective nutritional supplements in the field of human nutrition, but NR has better stability and more clinical data backing its use as a nutritional supplement for age-associated diseases. Some prefer NR as a nutritional supplement in human nutrition due to its easier absorption, which is particularly beneficial for managing age-associated diseases. Overall, NR’s proven effectiveness and stability make it a preferable choice in the context of human nutrition and age-associated diseases.

Why does David Sinclair take NMN and not NR?

David Sinclair advocates for NMN because he believes it is more directly converted into NAD+ within skeletal muscle cells and other cells, though both NMN and NR have shown efficacy as nutritional supplements. Sinclair’s preference for NMN as a nutritional supplement stems from its potential advantages over other options in skeletal muscle cells. The debate continues among experts about the effectiveness of different nutritional supplements like NMN and NR in improving skeletal muscle cells’ function. Nevertheless, Sinclair’s focus on NMN highlights the growing interest in nutritional supplements for enhancing cellular function.

What is the controversy with NMN?

The controversy around NMN involves regulatory issues, patent disputes, and debates over nicotinic acid’s bioavailability compared to NR, as well as the varying quality among different NMN products. Nicotinic acid plays a role in these discussions, as it is a precursor to NMN and its presence can influence NMN efficacy. The varying quality of NMN products may also reflect differences in the nicotinic acid used in their production. Additionally, regulatory challenges often involve the evaluation of nicotinic acid forms and their impact on NMN’s effectiveness. Understanding the interplay between nicotinic acid and NMN is crucial in navigating these controversies.

Reference

  1. Bieganowski P, Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell. 2004 May 14;117(4):495-502. doi: 10.1016/s0092-8674(04)00416-7. PMID: 15137942.

  2. Yang, N. C., Cho, Y. H., & Lee, I. (2019). The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD+ Level Is Lower than the Sirtuin-Saturating Concentrations. International journal of molecular sciences, 21(1), 142. https://doi.org/10.3390/ijms21010142.

  3. Hashimoto, T., Horikawa, M., Nomura, T., & Sakamoto, K. (2010). Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. Biogerontology, 11(1), 31–43. https://doi.org/10.1007/s10522-009-9225-3.

  4. Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011.

  5. Yaku, K., Okabe, K., & Nakagawa, T. (2018). NAD metabolism: Implications in aging and longevity. Ageing research reviews, 47, 1–17. https://doi.org/10.1016/j.arr.2018.05.006.

  6. Palacios, J. A., Herranz, D., De Bonis, M. L., Velasco, S., Serrano, M., & Blasco, M. A. (2010). SIRT1 contributes to telomere maintenance and augments global homologous recombination. The Journal of cell biology, 191(7), 1299–1313. https://doi.org/10.1083/jcb.201005160.

  7. Monaghan, P., & Haussmann, M. F. (2006). Do telomere dynamics link lifestyle and lifespan?. Trends in ecology & evolution, 21(1), 47–53. https://doi.org/10.1016/j.tree.2005.11.007.

  8. Monaghan P. (2010). Telomeres and life histories: the long and the short of it. Annals of the New York Academy of Sciences, 1206, 130–142. https://doi.org/10.1111/j.1749-6632.2010.05705.x.

  9. Wang, Y., Oxer, D., & Hekimi, S. (2015). Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nature communications, 6, 6393. https://doi.org/10.1038/ncomms7393.

  10. Lanza, I. R., & Nair, K. S. (2010). Mitochondrial function as a determinant of life span. Pflugers Archiv: European journal of physiology, 459(2), 277–289. https://doi.org/10.1007/s00424-009-0724-5.

  11. Sun, C., Wang, K., Stock, A. J., Gong, Y., Demarest, T. G., Yang, B., Giri, N., Harrington, L., Alter, B. P., Savage, S. A., Bohr, V. A., & Liu, Y. (2020). Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. The EMBO journal, 39(21), e103420. https://doi.org/10.15252/embj.2019103420.

  12. Belenky, P., Racette, F. G., Bogan, K. L., McClure, J. M., Smith, J. S., & Brenner, C. (2007). Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell, 129(3), 473–484. https://doi.org/10.1016/j.cell.2007.03.024.

  13. Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., Schoonjans, K., Menzies, K. J., & Auwerx, J. (2016). NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science (New York, N.Y.), 352(6292), 1436–1443. https://doi.org/10.1126/science.aaf2693.

  14. Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, A. A., & Auwerx, J. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell metabolism, 15(6), 838–847. https://doi.org/10.1016/j.cmet.2012.04.022.

  15. Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., Bellemin, S., Iyer, S. R., Wang, X., Gariani, K., Sauve, A. A., Cantó, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., … Auwerx, J. (2016). NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine, 8(361), 361ra139. https://doi.org/10.1126/scitranslmed.aaf5504.

  16. Sun, N., Youle, R. J., & Finkel, T. (2016). The Mitochondrial Basis of Aging. Molecular cell, 61(5), 654–666. https://doi.org/10.1016/j.molcel.2016.01.028.

  17. Khan, N. A., Auranen, M., Paetau, I., Pirinen, E., Euro, L., Forsström, S., Pasila, L., Velagapudi, V., Carroll, C. J., Auwerx, J., & Suomalainen, A. (2014). Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO molecular medicine, 6(6), 721–731. https://doi.org/10.1002/emmm.201403943.

  18. Brown, K. D., Maqsood, S., Huang, J. Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., & Jaffrey, S. R. (2014). Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss. Cell metabolism, 20(6), 1059–1068. https://doi.org/10.1016/j.cmet.2014.11.003.

  19. Harlan, B. A., Killoy, K. M., Pehar, M., Liu, L., Auwerx, J., & Vargas, M. R. (2020). Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models. Experimental neurology, 327, 113219. https://doi.org/10.1016/j.expneurol.2020.113219.

  20. Elhassan YS, Kluckova K, Fletcher RS, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. 2019;28(7):1717-1728.e6. doi:10.1016/j.celrep.2019.07.043.

  21. Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature communications, 9(1), 1286. https://doi.org/10.1038/s41467-018-03421-7.

  22. Frederick, D. W., Loro, E., Liu, L., Davila, A., Jr, Chellappa, K., Silverman, I. M., Quinn, W. J., 3rd, Gosai, S. J., Tichy, E. D., Davis, J. G., Mourkioti, F., Gregory, B. D., Dellinger, R. W., Redpath, P., Migaud, M. E., Nakamaru-Ogiso, E., Rabinowitz, J. D., Khurana, T. S., & Baur, J. A. (2016). Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell metabolism, 24(2), 269–282. https://doi.org/10.1016/j.cmet.2016.07.005.

  23. Sun, P., Qie, S., & Pan, B. (2022). Nicotinamide Riboside will Play an Important Role in Anti-aging Therapy in Humans, Especially in the Face Skin Anti-aging Treatment. Aesthetic plastic surgery, 46(Suppl 1), 192–194. https://doi.org/10.1007/s00266-021-02335-y.

  24. Dolopikou, C. F., Kourtzidis, I. A., Margaritelis, N. V., Vrabas, I. S., Koidou, I., Kyparos, A., Theodorou, A. A., Paschalis, V., & Nikolaidis, M. G. (2020). Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. European journal of nutrition, 59(2), 505–515. https://doi.org/10.1007/s00394-019-01919-4.

  25. Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, A. A., & Auwerx, J. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell metabolism, 15(6), 838–847. https://doi.org/10.1016/j.cmet.2012.04.022.

  26. Schaefer, P. M., Huang, J., Butic, A., Perry, C., Yardeni, T., Tan, W., Morrow, R., Baur, J. A., & Wallace, D. C. (2022). Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice. Molecular metabolism, 64, 101560. https://doi.org/10.1016/j.molmet.2022.101560.

  27. Pham, T. X., Bae, M., Kim, M. B., Lee, Y., Hu, S., Kang, H., Park, Y. K., & Lee, J. Y. (2019). Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis. Biochimica et biophysica acta. Molecular basis of disease, 1865(9), 2451–2463. https://doi.org/10.1016/j.bbadis.2019.06.009.

  28. Fluharty, N. T., & Brenner, C. (2020). Fat mobilization without weight loss is a potentially rapid response to nicotinamide riboside in obese people: it’s time to test with exercise. The American journal of clinical nutrition, 112(2), 243–244. https://doi.org/10.1093/ajcn/nqaa109.

  29. de Castro, J. M., Assumpção, J., Stein, D. J., Toledo, R. S., da Silva, L. S., Caumo, W., Carraro, C. C., da Rosa Araujo, A. S., & Torres, I. (2020). Nicotinamide riboside reduces cardiometabolic risk factors and modulates cardiac oxidative stress in obese Wistar rats under caloric restriction. Life sciences, 263, 118596. https://doi.org/10.1016/j.lfs.2020.118596.

  30. Lozada-Fernández, V. V., deLeon, O., Kellogg, S. L., Saravia, F. L., Hadiono, M. A., Atkinson, S. N., Grobe, J. L., & Kirby, J. R. (2022). Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice. mSystems, 7(1), e0023021. https://doi.org/10.1128/msystems.00230-21.

  31. de Castro, J. M., Stein, D. J., Medeiros, H. R., de Oliveira, C., & Torres, I. (2021). Nicotinamide Riboside Neutralizes Hypothalamic Inflammation and Increases Weight Loss Without Altering Muscle Mass in Obese Rats Under Calorie Restriction: A Preliminary Investigation. Frontiers in nutrition, 8, 648893. https://doi.org/10.3389/fnut.2021.648893.

  32. Kim, M. B., Pham, T. X., vanLuling, M., Kostour, V., Kang, H., Corvino, O., Jang, H., Odell, W., Bae, M., Park, Y. K., & Lee, J. Y. (2022). Nicotinamide riboside supplementation exerts an anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice. The Journal of nutritional biochemistry, 107, 109058. https://doi.org/10.1016/j.jnutbio.2022.109058.

  33. Ear, P. H., Chadda, A., Gumusoglu, S. B., Schmidt, M. S., Vogeler, S., Malicoat, J., Kadel, J., Moore, M. M., Migaud, M. E., Stevens, H. E., & Brenner, C. (2019). Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring. Cell reports, 26(4), 969–983.e4. https://doi.org/10.1016/j.celrep.2019.01.007.

  34. Shi, W., Hegeman, M. A., van Dartel, D., Tang, J., Suarez, M., Swarts, H., van der Hee, B., Arola, L., & Keijer, J. (2017). Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet. Molecular nutrition & food research, 61(8), 1600878. https://doi.org/10.1002/mnfr.201600878.

  35. Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, A. A., & Auwerx, J. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell metabolism, 15(6), 838–847. https://doi.org/10.1016/j.cmet.2012.04.022.

  36. Crisol, B. M., Veiga, C. B., Lenhare, L., Braga, R. R., Silva, V., da Silva, A., Cintra, D. E., Moura, L. P., Pauli, J. R., & Ropelle, E. R. (2018). Nicotinamide riboside induces a thermogenic response in lean mice. Life sciences, 211, 1–7. https://doi.org/10.1016/j.lfs.2018.09.015.

  37. Gomes, A. P., Price, N. L., Ling, A. J., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., Mercken, E. M., Palmeira, C. M., de Cabo, R., Rolo, A. P., Turner, N., Bell, E. L., & Sinclair, D. A. (2013). Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624–1638. https://doi.org/10.1016/j.cell.2013.11.037.

  38. Goody, M. F., & Henry, C. A. (2018). A need for NAD+ in muscle development, homeostasis, and aging. Skeletal muscle, 8(1), 9. https://doi.org/10.1186/s13395-018-0154-1.

  39. Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., Yoshino, J., & Imai, S. I. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell metabolism, 24(6), 795–806. https://doi.org/10.1016/j.cmet.2016.09.013.

  40. Remie, C., Roumans, K., Moonen, M., Connell, N. J., Havekes, B., Mevenkamp, J., Lindeboom, L., de Wit, V., van de Weijer, T., Aarts, S., Lutgens, E., Schomakers, B. V., Elfrink, H. L., Zapata-Pérez, R., Houtkooper, R. H., Auwerx, J., Hoeks, J., Schrauwen-Hinderling, V. B., Phielix, E., & Schrauwen, P. (2020). Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. The American journal of clinical nutrition, 112(2), 413–426. https://doi.org/10.1093/ajcn/nqaa072.

  41. Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019). NAD+ in Brain Aging and Neurodegenerative Disorders. Cell metabolism, 30(4), 630–655. https://doi.org/10.1016/j.cmet.2019.09.001.

  42. Mao, K., & Zhang, G. (2022). The role of PARP1 in neurodegenerative diseases and aging. The FEBS journal, 289(8), 2013–2024. https://doi.org/10.1111/febs.15716.

  43. Ying W. (2007). NAD+ and NADH in brain functions, brain diseases and brain aging. Frontiers in bioscience: a journal and virtual library, 12, 1863–1888. https://doi.org/10.2741/2194.

  44. Available from https://www.pnas.org/content/115/8/E1876.

  45. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617713/.

  46. Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., Wang, J., Sastre, M., Ono, K., Sauve, A. A., & Pasinetti, G. M. (2013). Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Neurobiology of aging, 34(6), 1581–1588. https://doi.org/10.1016/j.neurobiolaging.2012.12.005.

  47. Braidy, N., & Liu, Y. (2020). Can nicotinamide riboside protect against cognitive impairment?. Current opinion in clinical nutrition and metabolic care, 23(6), 413–420. https://doi.org/10.1097/MCO.0000000000000691.

  48. Larrick, J. W., & Mendelsohn, A. R. (2021). Modulation of cGAS-STING Pathway by Nicotinamide Riboside in Alzheimer’s Disease. Rejuvenation research, 24(5), 397–402. https://doi.org/10.1089/rej.2021.0062.

  49. Xie, X., Gao, Y., Zeng, M., Wang, Y., Wei, T. F., Lu, Y. B., & Zhang, W. P. (2019). Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer’s disease model mice. Metabolic brain disease, 34(1), 353–366. https://doi.org/10.1007/s11011-018-0346-8.

  50. Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P., & Bohr, V. A. (2018). NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proceedings of the National Academy of Sciences of the United States of America, 115(8), E1876–E1885. https://doi.org/10.1073/pnas.1718819115.

  51. Ryu, W. I., Shen, M., Lee, Y., Healy, R. A., Bormann, M. K., Cohen, B. M., & Sonntag, K. C. (2022). Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer’s disease. Aging cell, 21(7), e13658. https://doi.org/10.1111/acel.13658.

  52. Lee, H. J., & Yang, S. J. (2019). Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. International journal of molecular sciences, 20(17), 4196. https://doi.org/10.3390/ijms20174196.

  53. Schöndorf, D. C., Ivanyuk, D., Baden, P., Sanchez-Martinez, A., De Cicco, S., Yu, C., Giunta, I., Schwarz, L. K., Di Napoli, G., Panagiotakopoulou, V., Nestel, S., Keatinge, M., Pruszak, J., Bandmann, O., Heimrich, B., Gasser, T., Whitworth, A. J., & Deleidi, M. (2018). The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease. Cell reports, 23(10), 2976–2988. https://doi.org/10.1016/j.celrep.2018.05.009.

  54. Li, C. C., Chen, W. X., Wang, J., Xia, M., Jia, Z. C., Guo, C., Tang, X. Q., Li, M. X., Yin, Y., Liu, X., & Feng, H. (2020). Nicotinamide riboside rescues angiotensin II-induced cerebral small vessel disease in mice. CNS neuroscience & therapeutics, 26(4), 438–447. https://doi.org/10.1111/cns.13276.

  55. Available from https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.044746. 

  56. Nkrumah-Elie, Y., Erickson, A., Idoine, R., Ishtiaq, Y., Kwon, J., Rosene, M., & Shao, A. (2022). Nicotinamide Riboside Supports Brain Health: Assessing the Evidence. Current Developments in Nutrition, 6(Suppl 1), 798. https://doi.org/10.1093/cdn/nzac064.017.

  57. Cheng, Y. H., Zhao, J. H., Zong, W. F., Wei, X. J., Xu, Z., Yuan, Y., Jiang, Y. F., Luo, X., Wang, W., & Qu, W. S. (2022). Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury. Neurochemical research, 47(8), 2244–2253. https://doi.org/10.1007/s11064-022-03610-3.

  58. Vaur, P., Brugg, B., Mericskay, M., Li, Z., Schmidt, M. S., Vivien, D., Orset, C., Jacotot, E., Brenner, C., & Duplus, E. (2017). Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(12), 5440–5452. https://doi.org/10.1096/fj.201700221RR.

  59. Sundaresan, N. R., Gupta, M., Kim, G., Rajamohan, S. B., Isbatan, A., & Gupta, M. P. (2009). Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. The Journal of clinical investigation, 119(9), 2758–2771. https://doi.org/10.1172/JCI39162.

  60. Hafner, A. V., Dai, J., Gomes, A. P., Xiao, C. Y., Palmeira, C. M., Rosenzweig, A., & Sinclair, D. A. (2010). Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging, 2(12), 914–923. https://doi.org/10.18632/aging.100252.

  61. Sundaresan, N. R., Gupta, M., Kim, G., Rajamohan, S. B., Isbatan, A., & Gupta, M. P. (2009). Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. The Journal of clinical investigation, 119(9), 2758–2771. https://doi.org/10.1172/JCI39162.

  62. Yuan, Y., Liang, B., Liu, X. L., Liu, W. J., Huang, B. H., Yang, S. B., Gao, Y. Z., Meng, J. S., Li, M. J., Ye, T., Wang, C. Z., Hu, X. K., & Xing, D. M. (2022). Targeting NAD+: is it a common strategy to delay heart aging?. Cell death discovery, 8(1), 230. https://doi.org/10.1038/s41420-022-01031-3.

  63. de Castro JM, Assumpção JAF, Stein DJ, Toledo RS, da Silva LS, Caumo W, Carraro CC, da Rosa Araujo AS, Torres ILS. Nicotinamide riboside reduces cardiometabolic risk factors and modulates cardiac oxidative stress in obese Wistar rats under caloric restriction. Life Sci. 2020 Dec 15;263:118596. doi: 10.1016/j.lfs.2020.118596. Epub 2020 Oct 17. PMID: 33080243.

  64. Diguet, N., Trammell, S., Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., Gouge, A., Gressette, M., Manoury, B., Blanc, J., Breton, M., Decaux, J. F., Lavery, G. G., Baczkó, I., Zoll, J., Garnier, A., Li, Z., Brenner, C., & Mericskay, M. (2018). Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy. Circulation, 137(21), 2256–2273. https://doi.org/10.1161/CIRCULATIONAHA.116.026099.

  65. Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease, Daniel S. Matasic, Charles Brenner, and Barry London, American Journal of Physiology-Heart and Circulatory Physiology 2018 314:4, H839-H852.

  66. Ma, S., Feng, J., Lin, X., Liu, J., Tang, Y., Nie, S., Gong, J., & Wang, L. (2021). Nicotinamide Riboside Alleviates Cardiac Dysfunction and Remodeling in Pressure Overload Cardiac Hypertrophy. Oxidative medicine and cellular longevity, 2021, 5546867. https://doi.org/10.1155/2021/5546867.

  67. Abdellatif, M., Trummer-Herbst, V., Koser, F., Durand, S., Adão, R., Vasques-Nóvoa, F., Freundt, J. K., Voglhuber, J., Pricolo, M. R., Kasa, M., Türk, C., Aprahamian, F., Herrero-Galán, E., Hofer, S. J., Pendl, T., Rech, L., Kargl, J., Anto-Michel, N., Ljubojevic-Holzer, S., Schipke, J., … Sedej, S. (2021). Nicotinamide for the treatment of heart failure with preserved ejection fraction. Science translational medicine, 13(580), eabd7064. https://doi.org/10.1126/scitranslmed.abd7064.

  68. Ahmad, F., Tomar, D., Aryal A C, S., Elmoselhi, A. B., Thomas, M., Elrod, J. W., Tilley, D. G., & Force, T. (2020). Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling. Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165609. https://doi.org/10.1016/j.bbadis.2019.165609.

  69. Shahzadi, S. K., Marzook, H., Qaisar, R., & Ahmad, F. (2022). Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload. Clinical science (London, England : 1979), 136(2), 181–196. https://doi.org/10.1042/CS20210964.

  70. Zheng, D., Zhang, Y., Zheng, M., Cao, T., Wang, G., Zhang, L., Ni, R., Brockman, J., Zhong, H., Fan, G. C., & Peng, T. (2019). Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity. Clinical science (London, England : 1979), 133(13), 1505–1521. https://doi.org/10.1042/CS20181022.

  71. Hu, L., Guo, Y., Song, L., Wen, H., Sun, N., Wang, Y., Qi, B., Liang, Q., Geng, J., Liu, X., Fu, F., & Li, Y. (2022). Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway. Free radical biology & medicine, 183, 75–88. https://doi.org/10.1016/j.freeradbiomed.2022.03.012.

  72. Wu, L. E., Gomes, A. P., & Sinclair, D. A. (2014). Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis. Cancer cell, 25(1), 12–19. https://doi.org/10.1016/j.ccr.2013.12.005.

  73. Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., Hahn, W. C., Guarente, L. P., & Sinclair, D. A. (2008). The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PloS one, 3(4), e2020. https://doi.org/10.1371/journal.pone.0002020.

  74. Sebastián, C., Zwaans, B. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., Cosentino, C., Greenson, J. K., MacDonald, A. I., McGlynn, L., Maxwell, F., Edwards, J., Giacosa, S., Guccione, E., Weissleder, R., Bernstein, B. E., … Mostoslavsky, R. (2012). The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell, 151(6), 1185–1199. https://doi.org/10.1016/j.cell.2012.10.047.

  75. Nikas IP, Paschou SA, Ryu HS. The Role of Nicotinamide in Cancer Chemoprevention and Therapy. Biomolecules. 2020;10(3):477. Published 2020 Mar 20. doi:10.3390/biom10030477.

  76. Fania L, Mazzanti C, Campione E, Candi E, Abeni D, Dellambra E. Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention. Int J Mol Sci. 2019 Nov 26;20(23):5946. doi: 10.3390/ijms20235946. PMID: 31779194; PMCID: PMC6929077.

  77. Hwang ES, Song SB. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. doi: 10.1007/s00018-017-2527-8. Epub 2017 Apr 17. PMID: 28417163.

  78. Park, J. M., Han, Y. M., Lee, H. J., Park, Y. J., & Hahm, K. B. (2021). Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma-Induced Cancer Cachexia. Frontiers in pharmacology, 12, 665493. https://doi.org/10.3389/fphar.2021.665493.

  79. Hamity, M. V., White, S. R., Blum, C., Gibson-Corley, K. N., & Hammond, D. L. (2020). Nicotinamide riboside relieves paclitaxel-induced peripheral neuropathy and enhances suppression of tumor growth in tumor-bearing rats. Pain, 161(10), 2364–2375. https://doi.org/10.1097/j.pain.0000000000001924.

  80. Hamity, M. V., White, S. R., Walder, R. Y., Schmidt, M. S., Brenner, C., & Hammond, D. L. (2017). Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats. Pain, 158(5), 962–972. https://doi.org/10.1097/j.pain.0000000000000862.

  81. Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., Nikitin, G., Giger, S., Li, T. Y., Semilietof, A., Oggier, A., Yersin, Y., Tauzin, L., Pirinen, E., Cheng, W. C., Ratajczak, J., … Naveiras, O. (2019). The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. Cell stem cell, 24(3), 405–418.e7. https://doi.org/10.1016/j.stem.2019.02.012.

  82. Acklin, S., Sadhukhan, R., Du, W., Patra, M., Cholia, R., & Xia, F. (2022). Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation. Neuro-oncology advances, 4(1), vdac101. https://doi.org/10.1093/noajnl/vdac101.

  83. Podyacheva, E., & Toropova, Y. (2021). Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects. Nutrients, 13(10), 3435. https://doi.org/10.3390/nu13103435.

  84. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038/s41467-018-03421-7.

  85. Bushehri N, Jarrell ST, Lieberman S, Mirdamadi-Zonozi N, Birkmayer G, Preuss HG. Oral reduced B-nicotinamide adenine dinucleotide (NADH) affects blood pressure, lipid peroxidation, and lipid profile in hypertensive rats (SHR). GeriatrNephrol Urol. 1998;8(2):95-100. doi: 10.1023/a:1008242900153. PMID: 9893217.

  86. Trammell SA, Weidemann BJ, Chadda A, et al. Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice. Sci Rep. 2016;6:26933. Published 2016 May 27. doi:10.1038/srep26933.

  87. Shi W, Hegeman MA, Doncheva A, Bekkenkamp-Grovenstein M, de Boer VCJ, Keijer J. High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet. Nutrients. 2019; 11(10):2439. https://doi.org/10.3390/nu11102439.

  88. Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, JorisHoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen, Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans, The American Journal of Clinical Nutrition, Volume 112, Issue 2, August 2020, Pages 413–426, https://doi.org/10.1093/ajcn/nqaa072.

  89. Yang, S. J., Choi, J. M., Kim, L., Park, S. E., Rhee, E. J., Lee, W. Y., Oh, K. W., Park, S. W., & Park, C. Y. (2014). Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes. The Journal of nutritional biochemistry, 25(1), 66–72. https://doi.org/10.1016/j.jnutbio.2013.09.004.

  90. Lee, H. J., Hong, Y. S., Jun, W., & Yang, S. J. (2015). Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes. Journal of medicinal food, 18(11), 1207–1213. https://doi.org/10.1089/jmf.2015.3439.

  91. Trammell, S. A., Weidemann, B. J., Chadda, A., Yorek, M. S., Holmes, A., Coppey, L. J., Obrosov, A., Kardon, R. H., Yorek, M. A., & Brenner, C. (2016). Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice. Scientific reports, 6, 26933. https://doi.org/10.1038/srep26933.

  92. Wang SN, Miao CY. Targeting NAMPT as a therapeutic strategy against stroke. Stroke Vasc Neurol. 2019;4(2):83-89. Published 2019 Apr 5. doi:10.1136/svn-2018-000199.

  93. Fricker RA, Green EL, Jenkins SI, Griffin SM. The Influence of Nicotinamide on Health and Disease in the Central Nervous System. Int J Tryptophan Res. 2018;11:1178646918776658. Published 2018 May 21. doi:10.1177/1178646918776658.

  94. Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA. Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells. PLoS One. 2020 Sep 14;15(9):e0233477. doi: 10.1371/journal.pone.0233477. PMID: 32925933; PMCID: PMC7489539.

  95. Zhao Y, Guan YF, Zhou XM, Li GQ, Li ZY, Zhou CC, Wang P, Miao CY. Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade. Stroke. 2015 Jul;46(7):1966-74. doi: 10.1161/STROKEAHA.115.009216. Epub 2015 Jun 9. PMID: 26060246.

  96. Wang P, Miao CY. NAMPT as a Therapeutic Target against Stroke. Trends Pharmacol Sci. 2015 Dec;36(12):891-905. doi: 10.1016/j.tips.2015.08.012. Epub 2015 Nov 1. PMID: 26538317.

  97. Wang SN, Xu TY, Li WL, Miao CY. Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis. CNS NeurosciTher. 2016 Jun;22(6):431-9. doi: 10.1111/cns.12539. Epub 2016 Mar 28. PMID: 27018006; PMCID: PMC6492912.

  98. Ralto, K. M., Rhee, E. P., & Parikh, S. M. (2020). NAD+ homeostasis in renal health and disease. Nature reviews. Nephrology, 16(2), 99–111. https://doi.org/10.1038/s41581-019-0216-6.

  99. Hershberger KA, Martin AS, Hirschey MD. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017;13(4):213-225. doi:10.1038/nrneph.2017.5.

  100. Ralto, K.M., Rhee, E.P. & Parikh, S.M. NAD+ homeostasis in renal health and disease. Nat Rev Nephrol 16, 99–111 (2020). https://doi.org/10.1038/s41581-019-0216-6.

  101. Lenglet, A., Liabeuf, S., Guffroy, P. et al. Use of Nicotinamide to Treat Hyperphosphatemia in Dialysis Patients. Drugs R D 13, 165–173 (2013). https://doi.org/10.1007/s40268-013-0024-6.

  102. Simic, P., Vela Parada, X. F., Parikh, S. M., Dellinger, R., Guarente, L. P., & Rhee, E. P. (2020). Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI. BMC nephrology, 21(1), 342. https://doi.org/10.1186/s12882-020-02006-1.

  103. Lin, J. B., & Apte, R. S. (2018). NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies. Progress in retinal and eye research, 67, 118–129. https://doi.org/10.1016/j.preteyeres.2018.06.002.

  104. Zhang, X., Zhang, N., Chrenek, M. A., Girardot, P. E., Wang, J., Sellers, J. T., Geisert, E. E., Brenner, C., Nickerson, J. M., Boatright, J. H., & Li, Y. (2021). Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage. Pharmaceutics, 13(6), 893. https://doi.org/10.3390/pharmaceutics13060893.

  105. Available from https://www.biorxiv.org/content/10.1101/866798v1.full.

  106. Zhang, X., Henneman, N. F., Girardot, P. E., Sellers, J. T., Chrenek, M. A., Li, Y., Wang, J., Brenner, C., Nickerson, J. M., & Boatright, J. H. (2020). Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration. Investigative ophthalmology & visual science, 61(10), 47. https://doi.org/10.1167/iovs.61.10.47.

  107. Zhou, B., Zhao, G., Zhu, Y., Chen, X., Zhang, N., Yang, J., & Lin, H. (2021). Protective Effects of Nicotinamide Riboside on H2O2-induced Oxidative Damage in Lens Epithelial Cells. Current eye research, 46(7), 961–970. https://doi.org/10.1080/02713683.2020.1855662.

  108. Leung, C., Ren, S. T., Chan, P., Wan, K., Kam, A., Lai, G., Chiu, V., Ko, M., Yiu, C., & Yu, M. (2022). Correction to: Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial. Trials, 23(1), 134. https://doi.org/10.1186/s13063-022-06079-1.

  109. Leung, C., Ren, S. T., Chan, P., Wan, K., Kam, A., Lai, G., Chiu, V., Ko, M., Yiu, C., & Yu, M. (2022). Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial. Trials, 23(1), 45. https://doi.org/10.1186/s13063-021-05968-1.

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