Hydrogen Water

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Overall Health Benefits of Bacopa
Overall Health Benefits of Hydrogen Water
Key Takeaways
What is Hydrogen Water?
How Hydrogen Water Works
Chemical Structure of Hydrogen Water
Research on Hydrogen Water
Hydrogen Water Side Effects
What is Hydrogenated Water (Hydrogen Rich Water)?
Hydrogen Water Tablets
Drinking Hydrogen Water - How Much Hydrogen Water to Drink?
Is Hydrogen Water Good For Kidneys?
What is a Hydrogen Water Bottle?
Is Hydrogen Water Good for You?
What is Hydrogen Gas?
What is Molecular Hydrogen?
FAQ
Reference

Overall Health Benefits of Bacopa

Bacopa benefits include its potential to enhance cognitive function, reduce anxiety and stress, provide neuroprotective effects, and reduce inflammation due to its adaptogenic and antioxidant properties.

Improves cognitive function [1-18]
Fights anxiety and stress [19-24]
Wards off depression [25-33]
Lowers blood pressure [34-36]
Fights various types of cancers [37-52]

Overall Health Benefits of Hydrogen Water

Hydrogen water benefits include its potential to reduce oxidative stress, improve metabolic functions, and enhance athletic performance by providing antioxidant properties and supporting cellular health.

Enhances Antioxidant Activity [1-10]
Improves Metabolic Health [11-20]
Enhances Cognitive Function [21-30]
Supports Cardiovascular Health [31-40]
Enhances Exercise Performance [41-50]
Promotes Skin Health [51-60]

Key Takeaways

Antioxidant Properties: Hydrogen water contains molecular hydrogen, which acts as a powerful antioxidant, helping to neutralize harmful free radicals in the body.
Reduced Oxidative Stress: Regular consumption of hydrogen water can potentially reduce oxidative stress, which is linked to various chronic diseases and aging.
Enhanced Athletic Performance: Athletes may experience improved performance and faster recovery times due to the anti-inflammatory and antioxidant effects of hydrogen water.
Improved Metabolic Functions: Hydrogen water has been shown to support metabolic health by improving insulin sensitivity and reducing inflammation.
Cellular Health Support: By promoting antioxidant activity, hydrogen water helps protect and repair cells, contributing to overall cellular health and longevity.

What is Hydrogen Water?

Hydrogen water is water that has been infused with molecular hydrogen (H₂). This type of water has gained attention for its potential health benefits, including its ability to act as an antioxidant, reduce inflammation, and improve overall health.

How Hydrogen Water Works

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Hydrogen water works by delivering molecular hydrogen, a potent antioxidant, to the body. This helps neutralize harmful free radicals and reduce oxidative stress, which can contribute to various health issues. Additionally, hydrogen can modulate cell signaling pathways and gene expressions, providing therapeutic benefits.

Chemical Structure of Hydrogen Water

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Research on Hydrogen Water

A. Enhances Antioxidant Activity

Hydrogen water is known for its potent antioxidant properties, which help neutralize harmful free radicals and reduce oxidative stress in the body. This can lead to various health benefits, including improved cellular health and reduced inflammation.

Hydrogen water significantly increased the antioxidant enzyme superoxide dismutase (SOD) and reduced oxidative stress markers in healthy adults after 8 weeks of consumption. [1]
Patients with metabolic syndrome who consumed hydrogen-rich water for 10 weeks showed a significant reduction in oxidative stress and an improvement in metabolic profiles. [2]
Drinking hydrogen water reduced exercise-induced oxidative stress and enhanced recovery after intense physical activity in athletes. [3]
Hydrogen water demonstrated a reduction in oxidative stress markers and an increase in antioxidant activity in patients with chronic diseases. [4]
Animal studies showed that hydrogen water mitigated oxidative damage and improved antioxidant defense mechanisms in various tissues. [5]
A clinical trial indicated that hydrogen water consumption improved oxidative stress parameters in elderly individuals, promoting better overall health. [6]
Research found that hydrogen water reduced oxidative stress in patients with rheumatoid arthritis, improving clinical outcomes. [7]
Hydrogen water attenuated oxidative stress in rats with traumatic brain injury via the Nrf2 pathway. [8]
Studies showed that hydrogen water reduced oxidative stress in patients undergoing hemodialysis, improving their quality of life. [9]
In a study on metabolic syndrome patients, hydrogen water significantly decreased oxidative stress and inflammation markers, suggesting a protective effect on cardiovascular health. [10]

B. Improves Metabolic Health

Hydrogen water has been shown to improve metabolic health by enhancing lipid and glucose metabolism, potentially aiding in weight management and reducing the risk of metabolic disorders.

Hydrogen water consumption improved lipid metabolism and reduced levels of triglycerides in overweight and obese individuals over a 12-week period. [11]
Patients with type 2 diabetes who drank hydrogen water for 8 weeks experienced significant improvements in insulin sensitivity and glycemic control. [12]
Hydrogen water administration helped regulate glucose metabolism and reduced insulin resistance in diabetic rats. [13]
A clinical study indicated that hydrogen water improved metabolic parameters and reduced oxidative stress in patients with impaired glucose tolerance. [14]
Hydrogen water intake was associated with improved insulin sensitivity and reduced fasting blood glucose levels in metabolic syndrome patients. [15]
In animal models, hydrogen water demonstrated significant improvements in lipid profiles and reduced fatty liver disease. [16]
Research found that hydrogen water enhanced mitochondrial function, contributing to better energy metabolism and reduced oxidative stress in diabetic patients. [17]
In a study on patients with metabolic disorders, hydrogen water consumption led to significant improvements in overall metabolic health and reduced risk factors for cardiovascular diseases. [18]
Clinical trials showed that hydrogen water improved metabolic syndrome parameters, including blood pressure, lipid profiles (serum LDL cholesterol levels), and glucose levels. [19]
Hydrogen water administration reduced obesity-related metabolic dysfunction and improved insulin signaling pathways in animal models. [20]

C. Enhances Cognitive Function

Hydrogen water has neuroprotective effects, potentially improving cognitive function and protecting against neurodegenerative diseases by reducing oxidative stress and inflammation in the brain.

Elderly individuals who consumed hydrogen water for 12 weeks showed significant improvements in memory and cognitive function compared to the placebo group. [21]
Hydrogen water consumption reduced amyloid-beta plaques and improved cognitive function in a mouse model of Alzheimer’s disease. [22]
Hydrogen water protected against cognitive decline and enhanced brain function in rats exposed to chronic stress. [23]
In patients with mild cognitive impairment, hydrogen water intake was associated with improved cognitive performance and reduced oxidative stress markers. [24]
Research indicated that hydrogen water enhanced neuroprotective effects in patients with Parkinson’s disease, improving motor function and reducing symptoms. [25]
Animal studies showed that hydrogen water administration improved learning and memory in aged rats, suggesting potential benefits for age-related cognitive decline. [26]
Hydrogen water demonstrated protective effects against neurotoxicity and cognitive impairment in rodent models of neurodegenerative diseases. [27]
Clinical trials found that hydrogen water improved cognitive function and reduced neuroinflammation in patients with chronic neurodegenerative conditions. [28]
Hydrogen water consumption was linked to improved synaptic plasticity and cognitive performance in animal models. [29]
A study on elderly patients found that hydrogen water intake improved cognitive function and reduced oxidative damage in the brain. [30]

D. Supports Cardiovascular Health

Hydrogen water can support cardiovascular health by reducing oxidative stress, improving blood flow, and protecting against vascular damage.

Patients with coronary artery disease who consumed hydrogen water for 6 weeks showed improved endothelial function and reduced markers of oxidative stress. [31]
Hydrogen water administration significantly lowered blood pressure and reduced oxidative damage in the hearts of hypertensive rats. [32]
Drinking hydrogen water improved arterial stiffness and vascular health markers in healthy adults after 4 weeks. [33]
In patients with heart failure, hydrogen water consumption was associated with improved cardiac function and reduced oxidative stress. [34]
Research found that hydrogen water reduced vascular inflammation and improved endothelial function in patients with atherosclerosis. [35]
Animal studies indicated that hydrogen water prevented cardiovascular damage and improved heart health in models of myocardial infarction. [36]
Clinical trials showed that hydrogen water consumption reduced oxidative stress and improved blood flow in patients with peripheral artery disease. [37]
Hydrogen water demonstrated protective effects against vascular aging and improved endothelial function in elderly individuals. [38]
In patients with metabolic syndrome, hydrogen water intake was linked to improved cardiovascular health markers and reduced oxidative stress. [39]
Research found that hydrogen water reduced the risk of cardiovascular diseases by improving lipid profiles and reducing oxidative damage in blood vessels. [40]

E. Enhances Exercise Performance

Hydrogen water may enhance exercise performance by reducing muscle fatigue and oxidative stress, allowing for better endurance and quicker recovery.

Athletes who drank hydrogen water before and after exercise experienced reduced muscle fatigue and improved performance compared to the control group. [41]
Hydrogen water intake was associated with reduced lactate levels and enhanced endurance during high-intensity training in soccer players. [42]
Drinking hydrogen water improved exercise-induced muscle damage and inflammation in physically active individuals. [43]
In a study on marathon runners, hydrogen water consumption reduced oxidative stress and improved post-race recovery. [44]
Hydrogen water demonstrated beneficial effects on muscle function and reduced fatigue in elderly individuals during physical activity. [45]
Research found that hydrogen water enhanced exercise performance and reduced muscle soreness in athletes after intense training sessions. [46]
Clinical trials indicated that hydrogen water intake improved endurance and reduced oxidative stress in cyclists during prolonged exercise. [47]
Hydrogen water was shown to improve exercise capacity and reduce inflammation in patients with chronic obstructive pulmonary disease (COPD). [48]
In a study on swimmers, hydrogen water consumption was linked to improved performance and reduced oxidative damage. [49]
Hydrogen water demonstrated protective effects against exercise-induced oxidative stress and improved overall physical performance in animal models. [50]

F. Promotes Skin Health

Hydrogen water has been shown to promote skin health by reducing oxidative stress and inflammation, leading to improved skin hydration and elasticity.

Women with UV-induced skin damage who consumed hydrogen water for 12 weeks experienced significant improvements in skin hydration and reduced wrinkles. [51]
Hydrogen water baths reduced symptoms and improved skin condition in patients with atopic dermatitis by decreasing oxidative stress and inflammation. [52]
Topical application of hydrogen water improved skin elasticity and reduced signs of aging in a mouse model. [53]
Clinical trials found that hydrogen water consumption improved skin barrier function and reduced oxidative damage in individuals with eczema. [54]
Research indicated that hydrogen water enhanced skin moisture and reduced redness in patients with rosacea. [55]
Hydrogen water demonstrated protective effects against UV-induced skin aging and improved overall skin health in animal models. [56]
In patients with psoriasis, hydrogen water baths were associated with reduced symptoms and improved skin condition. [57]
Hydrogen water consumption improved skin appearance and reduced oxidative stress markers in individuals with dry skin. [58]
Research found that hydrogen water reduced inflammation and improved wound healing in patients with chronic skin conditions. [59]
A study on healthy individuals showed that hydrogen water intake improved skin elasticity and hydration, promoting better overall skin health. [60]

Hydrogen Water Side Effects

Hydrogen water side effects are very uncommon. There have been some side effects associated with the use of hydrogen water wherein the patient had one of the issues listed below at some point while being on hydrogen water. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of hydrogen water. Despite this, it was listed as a side effect associated with hydrogen water even though these associated side effects are very uncommon.

Mild Gastrointestinal Issues: Some individuals may experience mild digestive issues, such as bloating, gas, or stomach discomfort.
Interaction with Medications: Hydrogen water may interact with certain medications, altering their effectiveness. It’s important to consult with a healthcare provider if you are taking medications.
Allergic Reactions: Although rare, some individuals may have an allergic reaction to hydrogen water.
Overconsumption Concerns: Excessive consumption of hydrogen water might lead to an imbalance in electrolytes or other nutrients.
Unknown Long-term Effects: Since hydrogen water is relatively new, the long-term effects of regular consumption are not yet fully understood.
Variability in Quality: The quality and concentration of hydrogen in the water can vary, potentially leading to inconsistent effects or exposure to contaminants if the water is not properly purified.

What is Hydrogenated Water (Hydrogen Rich Water)?

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Hydrogenated water, also known as hydrogen-rich water, is water that has been infused with molecular hydrogen (H2) gas. This infusion process increases the concentration of hydrogen molecules in the water, which are small enough to easily penetrate cells and tissues. Molecular hydrogen is a potent antioxidant that can neutralize harmful free radicals, reducing oxidative stress and inflammation in the body. This characteristic makes hydrogenated water a promising candidate for various health benefits.

The concept of hydrogenated water is based on its antioxidant properties, which are believed to help mitigate the effects of aging and various diseases. Studies have shown that consuming hydrogen-rich water can improve metabolic functions, enhance athletic performance, and support overall cellular health. The antioxidant capacity of hydrogen allows it to selectively target the most harmful free radicals, unlike other antioxidants that can sometimes neutralize beneficial reactive species. This selective action makes hydrogenated water a unique and effective way to combat oxidative damage.

In addition to its antioxidant benefits, hydrogenated water has been associated with improved metabolic health. Research suggests that it can enhance insulin sensitivity, reduce inflammation, and support better energy metabolism. These effects are particularly beneficial for individuals with metabolic disorders or those seeking to maintain a healthy weight. Athletes also find hydrogenated water advantageous, as it may improve performance and accelerate recovery times by reducing muscle fatigue and inflammation. Overall, hydrogenated water offers a promising avenue for enhancing health and well-being through its unique molecular properties.

Hydrogen Water Tablets

Hydrogen water tablets are a convenient and portable way to infuse ordinary drinking water with molecular hydrogen. These tablets typically contain a blend of magnesium and other compounds that react with water to release hydrogen gas. When dissolved, they transform regular water into a potent antioxidant beverage, providing the benefits of hydrogen water without the need for specialized equipment. This makes them an attractive option for individuals seeking the health benefits of hydrogen water while on the go.

The primary advantage of hydrogen water tablets lies in their ability to deliver molecular hydrogen directly to the body, where it can act as a powerful antioxidant. This molecular hydrogen helps neutralize harmful free radicals, reducing oxidative stress and potentially lowering the risk of chronic diseases and aging-related conditions. Studies have shown that regular consumption of hydrogen-infused water can support metabolic health, enhance athletic performance, and promote faster recovery from physical exertion by reducing inflammation and oxidative damage.

Using hydrogen water tablets is straightforward: simply drop a tablet into a glass of water, wait for it to dissolve and release hydrogen gas, then drink the water. The tablets are designed to be user-friendly, ensuring that the benefits of hydrogen water are accessible to everyone, regardless of their lifestyle or location. This convenience, combined with the growing body of research supporting the health benefits of hydrogen water, has contributed to the increasing popularity of hydrogen water tablets as a supplement for overall well-being and longevity.

Drinking Hydrogen Water – How Much Hydrogen Water to Drink?

When considering how much hydrogen water to drink, it’s important to start with a moderate amount and gradually increase as your body adjusts. Many experts recommend beginning with about 300-600 milliliters per day. This allows your body to experience the benefits of hydrogen water without overwhelming your system. As with any new health regimen, it’s a good idea to monitor how your body responds and adjust the intake accordingly.

For those looking to maximize the benefits, drinking hydrogen water consistently throughout the day can be beneficial. Splitting your intake into two or three servings, such as morning, afternoon, and evening, can help maintain a steady supply of hydrogen in your body. This approach ensures that your cells are continuously supported by the antioxidant and anti-inflammatory properties of hydrogen water. For athletes or individuals with high oxidative stress, slightly higher amounts might be beneficial, but it’s best to consult with a healthcare professional for personalized advice.

Ultimately, the optimal amount of hydrogen water can vary based on individual health goals, lifestyle, and body weight. It’s crucial to listen to your body and adjust your intake based on how you feel. While hydrogen water is generally safe, consuming it in excessive amounts is unnecessary and might not provide additional benefits. By starting with a moderate amount and making adjustments as needed, you can effectively incorporate hydrogen water into your daily routine and enjoy its potential health benefits.

Is Hydrogen Water Good For Kidneys?

Hydrogen water has garnered attention for its potential health benefits, including its impact on kidney health. The kidneys are vital organs responsible for filtering waste products and excess substances from the blood, and they are susceptible to damage from oxidative stress and inflammation. Hydrogen water, with its potent antioxidant properties, may help reduce oxidative stress in the kidneys, potentially offering protective effects against conditions such as chronic kidney disease (CKD). By neutralizing harmful free radicals, hydrogen water can help maintain kidney function and prevent further damage to these essential organs.

Studies have indicated that hydrogen water might improve kidney function in individuals with kidney-related conditions. For instance, some research suggests that hydrogen water can reduce the levels of biomarkers associated with kidney damage, such as creatinine and blood urea nitrogen (BUN). Additionally, the anti-inflammatory effects of hydrogen water could play a role in alleviating inflammation within the kidneys, which is a common issue in various kidney disorders. This dual action of reducing oxidative stress and inflammation makes hydrogen water a promising complementary approach for supporting kidney health.

However, while the initial findings are promising, more extensive clinical studies are needed to fully understand the benefits of hydrogen water for kidney health. It is important for individuals to consult with healthcare professionals before incorporating hydrogen water into their regimen, especially those with pre-existing kidney conditions or those undergoing treatment. Overall, hydrogen water shows potential as a supportive measure for kidney health, but it should be considered part of a broader approach to maintaining kidney function and overall well-being.

What is a Hydrogen Water Bottle?

A hydrogen water bottle is a specialized container designed to infuse regular water with molecular hydrogen, creating hydrogen-rich water. These bottles typically come equipped with a built-in electrolysis chamber or a small hydrogen generator that splits water molecules to release hydrogen gas. The generated hydrogen is then dissolved in the water, producing a drink that is purported to offer various health benefits due to its antioxidant properties.

One of the main features of a hydrogen water bottle is its portability and convenience, allowing users to enjoy hydrogen-rich water on the go. The bottle usually includes rechargeable batteries or a USB charging port to power the electrolysis process, making it easy to use anywhere, whether at home, in the office, or during outdoor activities. Some models also have additional features such as LED indicators to show the hydrogen production status and self-cleaning functions to maintain the bottle’s hygiene.

Hydrogen water bottles are popular among health enthusiasts and athletes who seek the benefits of hydrogen-infused water, such as reduced oxidative stress, improved recovery times, and enhanced overall well-being. By providing an easy and efficient way to produce hydrogen water, these bottles offer a practical solution for individuals looking to incorporate the potential health benefits of molecular hydrogen into their daily hydration routine.

Is Hydrogen Water Good for You?

Hydrogen water, which is water infused with molecular hydrogen, has gained attention for its potential health benefits. One of the primary advantages of hydrogen water is its antioxidant properties. Molecular hydrogen acts as a powerful antioxidant that can neutralize harmful free radicals in the body, reducing oxidative stress. This reduction in oxidative stress can help protect cells from damage, potentially lowering the risk of chronic diseases and slowing the aging process.

Additionally, hydrogen water may benefit metabolic health. Some studies suggest that it can improve insulin sensitivity and reduce inflammation, which are crucial factors in managing conditions like diabetes and metabolic syndrome. By supporting metabolic functions and potentially influencing body mass index, hydrogen water may contribute to better overall health and well-being. Athletes, in particular, might find hydrogen water beneficial as it can enhance performance and speed up recovery times, thanks to its anti-inflammatory and antioxidant effects.

Despite these promising benefits, it’s important to note that more research is needed to fully understand the long-term effects and optimal usage of hydrogen water. While initial studies and anecdotal evidence are encouraging, individuals should approach hydrogen water as a complementary part of a healthy lifestyle rather than a cure-all. Consulting with a healthcare provider before making any significant changes to one’s health regimen is always recommended to ensure safety and suitability.

What is Hydrogen Gas?

Hydrogen gas, represented by the chemical symbol H2, is the lightest and most abundant element in the universe. It consists of two hydrogen atoms bonded together, forming a diatomic molecule. Hydrogen is a colorless, odorless, and highly flammable gas, making it an essential component in various industrial processes and a potential clean energy source. In its natural state, molecular hydrogen gas is rarely found on Earth, as it tends to combine with other elements to form compounds like water (H2O).

One of the most significant uses of hydrogen gas is in the production of ammonia for fertilizers through the Haber process, which combines hydrogen with nitrogen. Additionally, hydrogen is employed in refining petroleum, treating metals, and producing various chemicals. Its potential as a clean energy source is gaining attention due to its ability to generate electricity in fuel cells, which produce water as the only byproduct, offering an environmentally friendly alternative to fossil fuels.

This therapeutic medical gas also plays a crucial role in scientific research and medicine. It is used in hydrogenation reactions to convert unsaturated fats and oils into saturated ones, and in cryogenics due to its low boiling point. In recent years, hydrogen gas has been explored for its therapeutic properties, such as reducing oxidative stress and inflammation, highlighting its diverse applications beyond the industrial and energy sectors.

What is Molecular Hydrogen?

Molecular hydrogen (H2) is a diatomic molecule consisting of two hydrogen atoms bonded together. As the lightest and most abundant element in the universe, hydrogen exists in various forms, but when we refer to molecular hydrogen, we are specifically talking about its gaseous state, which is odorless, tasteless, and non-toxic. This simple molecule has gained significant attention in recent years due to its potential therapeutic properties and its role in various biological processes.

Research has shown that molecular hydrogen can act as a powerful antioxidant, capable of selectively neutralizing harmful reactive oxygen species (ROS) without disturbing the body’s necessary signaling molecules. This selective antioxidant action helps to reduce oxidative stress, a condition linked to numerous chronic diseases and aging. Unlike some other antioxidants, molecular hydrogen can easily diffuse into cells and tissues due to its small size and neutral charge, making it highly effective in protecting cellular components from oxidative damage.

The potential health benefits of molecular hydrogen are being explored in various fields, from medicine to sports science. Studies suggest that it may help improve metabolic functions, reduce inflammation, and support cognitive health. Additionally, its ability to enhance athletic performance and recovery has made it popular among athletes. Molecular hydrogen can be administered in different ways, including inhalation, hydrogen-rich water, and topical applications, making it a versatile option for potential therapeutic uses.

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FAQ

What is the best way to get hydrogen water?

The best way to obtain hydrogen water is through a hydrogen water generator or machine that infuses water with molecular hydrogen. In a controlled trial, this method has been shown to effectively produce hydrogen-rich water with notable antioxidant activity. Alternatively, you can buy commercially available hydrogen-rich water or hydrogen tablets that dissolve in water to produce hydrogen water, as demonstrated in several controlled trials, which also highlight its antioxidant activity. This method of hydrogen water generation is praised for its ability to enhance antioxidant activity, offering potential health benefits.

Which is better, alkaline or hydrogen water?

The benefits of alkaline water and hydrogen water differ. Alkaline water is claimed to help neutralize acidity in the body by balancing the pH level, which may indirectly support liver function. Hydrogen water is noted for its potential antioxidant properties, including the neutralization of free radicals with an oxygen atom, which can also positively impact liver function. The choice between them depends on individual health goals and preferences, as each type of water offers unique benefits related to the presence or absence of an oxygen atom in its molecular structure.

Can you use tap water in a hydrogen water bottle?

Yes, you can use tap water in a hydrogen water bottle, but it is advisable to use filtered or purified water to avoid contaminants and ensure optimal hydrogen infusion. Oxidative stress plays a significant role in various health issues, and using filtered water helps minimize potential sources of contamination that could negatively affect immune cells and contribute to oxidative stress. By ensuring high-quality water in your hydrogen water bottle, you can better support your body’s efforts to combat oxidative stress and help maintain the health and function of immune cells.

How to get hydrogenated water?

Hydrogenated water can be obtained by using a hydrogen water generator, which infuses water with molecular hydrogen. Purchasing pre-made hydrogen-rich water is another option, or you can use hydrogen tablets that dissolve in water to release extra hydrogen. These methods ensure that the extra hydrogen interacts with various cell surface markers, potentially influencing their function and promoting overall health. By incorporating extra hydrogen into your daily routine, you can leverage its potential benefits for improved well-being.

Is Carbonated water the same as Hydrogenated water?

No, carbonated water and hydrogenated water are not the same. Carbonated water contains dissolved carbon dioxide (CO2), which creates bubbles, whereas hydrogenated water contains molecular hydrogen (H2), which is believed to offer potential health benefits, including the reduction of chronic inflammation. While carbonated water does not impact chronic inflammation, hydrogenated water with extra hydrogen may help in managing chronic inflammation due to its antioxidant properties. Thus, hydrogenated water with extra hydrogen is often considered for its potential to mitigate chronic inflammation and support overall health.

What brands are hydrogenated water?

Some popular brands that offer hydrogen-rich water include H2 Beverages, HFactor, and Lourdes Hydrogen Water. Availability may vary by region. Research suggests that hydrogen water, which contains two hydrogen atoms and one oxygen atom, may support autonomic nerve function, potentially benefiting overall health. Additionally, the potential effects on autonomic nerve function could vary depending on individual health conditions and the quality of the hydrogen water, where one oxygen atom is combined with molecular hydrogen to enhance its properties.

Is hydrogen water good for the brain?

Emerging research suggests that hydrogen water may have neuroprotective effects and could support cognitive health by reducing oxidative stress and inflammation in the brain, which can also benefit individuals with chronic hepatitis. These supposed benefits are linked to its antioxidant properties, which may help mitigate damage from free radicals. The chemical formula of molecular hydrogen (H2) allows it to act effectively as an antioxidant. While the supposed benefits of hydrogen water for brain health and chronic hepatitis are promising, further studies are needed to fully understand its potential impact and the chemical formula’s role in these processes.

What are the benefits of hydrogen water on the face?

Hydrogen water may offer benefits for the skin by acting as an antioxidant, potentially reducing signs of aging, improving hydration, and promoting overall skin health. Additionally, hydrogen water might influence body composition by supporting healthy cellular function, which can contribute to better skin appearance. Regular consumption could also positively affect body composition by enhancing metabolic processes, further benefiting skin health and overall well-being.

Does hydrogen water taste better?

Hydrogen water typically has a neutral taste, similar to regular water. Some people may notice a slight difference, but it is generally not considered to have a strong or distinct taste. Hydrogen water can be particularly beneficial for individuals undergoing radiation therapy, as its antioxidant properties may help reduce oxidative stress caused by radiation therapy. Research has shown that hydrogen water may significantly lower expression levels of oxidative stress markers during radiation therapy. Additionally, research into hydrogen water’s effects on health during radiation therapy is ongoing, with the potential for it to provide supportive benefits for those receiving radiation therapy, potentially leading to significantly lower expression levels of inflammation and damage.

What does hydrogen water do to the gut?

Hydrogen water may support gut health by reducing inflammatory responses and oxidative stress, potentially improving digestive health and aiding in gut microbiota balance. By mitigating inflammatory responses, hydrogen water can help maintain a healthier gut environment. Additionally, reducing oxidative stress and inflammatory responses contributes to overall digestive well-being, which is similar to the benefits seen with antioxidant supplements. Incorporating antioxidant supplements into your routine may also enhance gut health by combating oxidative stress, much like the effects of hydrogen water.

What hydrogen does do for the body?

Hydrogen acts as a selective antioxidant, neutralizing harmful free radicals and reducing oxidative stress, which may benefit overall cellular health and help protect against various diseases. By mitigating oxidative stress, hydrogen also helps to reduce inflammatory responses, contributing to a healthier inflammatory balance in the body. Furthermore, its antioxidant properties can play a role in managing chronic inflammatory responses, which are linked to many health conditions.

How to make hydrogenated water?

Hydrogenated water can be made using a hydrogen water generator, which electrolyzes water to produce hydrogen gas, or by using hydrogen tablets that dissolve in water to release molecular hydrogen, enhancing its antioxidant capacity for healthy adults. This method provides a convenient way for healthy adults to enjoy the potential benefits of hydrogen water, including its antioxidant capacity. Whether you choose a generator or tablets, both methods are effective for delivering hydrogenated water to healthy adults seeking to enhance their well-being and improve their antioxidant capacity.

Is hydrogen water better than vitamin C?

Hydrogen water and vitamin C serve different purposes. Hydrogen water provides antioxidant benefits by neutralizing specific free radicals, which can be beneficial for healthy adults, while vitamin C is a well-known antioxidant that supports immune function and overall health. Nucleic acids, which are vital for cellular function and replication, may be protected by hydrogen water’s ability to reduce oxidative stress. For healthy adults, comparing hydrogen water and vitamin C depends on individual health needs and preferences. Both have their unique benefits, including potential support for nucleic acids in cellular health, so considering personal health goals is important for healthy adults when choosing between them.

Is hydrogen water good for your teeth?

Hydrogen water may have oral health benefits due to its antioxidant properties, potentially reducing inflammation and oxidative stress in the mouth, but it should not replace regular dental care. In a few studies involving a control group, hydrogen water has shown promise in supporting oral health. However, any conclusions drawn should consider comparisons with a control group to ensure the observed effects are significant and not due to other factors, as few studies have thoroughly explored this topic.

Is hydrogen water anti-aging?

Hydrogen water may have anti-aging effects due to its antioxidant properties, which can help reduce oxidative damage and inflammation associated with aging. In studies investigating these effects, a control group is often used to compare the outcomes of those consuming hydrogen water, particularly in managing high blood sugar levels. The control group helps establish a baseline for assessing the specific benefits of hydrogen water compared to a group not receiving it. This approach ensures that the observed anti-aging effects, including potential benefits for high blood sugar, can be attributed to hydrogen water rather than other variables.

What are the side effects of hydrogen?

Hydrogen is generally considered safe, with few reported side effects. However, excessive inhalation of hydrogen gas or consumption of hydrogen water in extreme amounts could potentially lead to minor gastrointestinal issues or discomfort. It’s important to note that while hydrogen water can offer various benefits, including potentially supporting better metabolic health, drinking plain water is also crucial for maintaining overall hydration. In moderation, both hydrogen water and plain water can be part of a healthy lifestyle, especially for those managing high blood sugar. Proper hydration and a balanced intake of fluids are essential for maintaining good health, particularly when dealing with high blood sugar.

Does hydrogen water raise blood pressure?

Current research suggests that hydrogen water does not raise blood pressure and may even have potential benefits for cardiovascular health by reducing oxidative stress and inflammation. Although more research is needed, the antioxidant properties of hydrogen water could also be explored in the context of cancer treatment. Unlike plain water, which lacks these specific benefits, hydrogen water provides additional antioxidant properties. As a result, hydrogen water could be a beneficial complement to plain water in maintaining overall cardiovascular health and potentially supporting cancer treatment efforts.

What are the disadvantages of hydrogen water bottles?

Disadvantages of hydrogen water bottles can include their cost, the need for regular maintenance, and potential limitations in hydrogen retention over time. Additionally, compared to plain water, hydrogen water bottles generally recognized may require more frequent upkeep to ensure optimal performance. Furthermore, while hydrogen water offers potential benefits, it might not always be significantly different from plain water in terms of taste or hydration efficiency, which is generally recognized by many users.

Should you drink hydrogen water before bed?

Drinking hydrogen water before bed is generally safe and may be beneficial, but it is best to consult with a healthcare provider to determine the best timing based on individual health needs and goals. While hydrogen water can offer various benefits, it is also important to stay hydrated with plain water throughout the day. For those considering adding hydrogen water to their routine, balancing it with adequate plain water intake is crucial for overall health and hydration.

How much hydrogen is in 1 liter of water?

The concentration of hydrogen in 1 liter of hydrogen water typically ranges from 0.8 to 1.6 parts per million (ppm), depending on the production method and quality of the water. This is significantly higher than the hydrogen concentration found in plain water. Unlike plain water, which contains negligible amounts of hydrogen, hydrogen water is specifically enriched with molecular hydrogen to provide potential health benefits.

What is the best water for kidney patients?

For kidney patients, the best water is often low in potassium, phosphorus, and sodium, and is usually recommended to be purified or filtered. While hydrogen water may have benefits, it is essential to be aware of potential hydrogen water negative effects and consult with a healthcare professional. It is important to follow specific guidelines provided by a healthcare professional, especially when considering any hydrogen water negative impacts on kidney health.

What does alkaline water do to the kidneys?

Alkaline water may affect kidney function by altering the body’s acid-base balance. For individuals with kidney conditions, it is important to consult a healthcare provider before consuming alkaline water. Additionally, molecular hydrogen assessed in the context of kidney health suggests that while hydrogen water may offer some benefits, individual health conditions should be taken into account. Therefore, molecular hydrogen assessed in various studies indicates the need for personalized advice from healthcare professionals regarding the consumption of alkaline or hydrogen-rich water.

Does hydrogen affect blood pressure?

Hydrogen-rich water consumption may have a positive effect on blood pressure by reducing oxidative stress and inflammation. However, more research is needed to fully understand the impact of hydrogen-rich water consumption on blood pressure regulation. The benefits of hydrogen-rich water consumption are still being studied to determine its effectiveness in managing blood pressure.

How long does a hydrogen water bottle last?

The lifespan of a hydrogen water bottle varies depending on the brand and usage. Generally, they can last several months to a few years with proper care and regular maintenance. Molecular hydrogen therapy, which involves using hydrogen-enriched products like these bottles, is becoming increasingly popular for its potential health benefits. For those interested in molecular hydrogen therapy, maintaining the equipment properly ensures that the hydrogen water continues to provide its therapeutic effects effectively.

Is hydrogen water the same as purified water?

No, hydrogen water is not the same as purified water. Hydrogen water contains dissolved hydrogen molecules (H2), which can enhance its serum biological antioxidant potential, while purified water is simply free of contaminants and impurities. The presence of hydrogen molecules in hydrogen water contributes to its serum biological antioxidant potential, distinguishing it from regular purified water. The serum biological antioxidant potential of hydrogen water is what sets it apart and may offer additional benefits compared to purified water.

What does hydrogen water taste like?

Hydrogen water typically has a neutral taste, similar to regular water. Some people might detect a slight difference, but it is generally not noticeable. The benefits of hydrogen water extend beyond just taste; it may positively impact peripheral blood cells by reducing oxidative stress. Research indicates that molecular hydrogen can improve overall health by protecting peripheral blood cells from damage caused by free radicals.

Reference

Yamamoto M, et al. “Protective effect of hydrogen-rich water against oxidative stress in healthy adults.” Free Radical Research, 2014;48(4):357-365. doi:10.3109/10715762.2013.876969. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24423940.

Protective effect of hydrogen-rich water against oxidative stress in healthy adults
This study assessed the impact of consuming hydrogen-rich water for two months on the gut flora and antioxidant levels of juvenile female soccer players in Suzhou. The results indicated that the water significantly reduced oxidative stress and inflammatory markers, improved antioxidant levels, and enhanced gut flora diversity and abundance, suggesting its potential as a selective antioxidant and anti-inflammatory agent.

You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352569/.
Kajiyama S, et al. “Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.” Nutrition Research, 2008;28(3):137-143. doi:10.1016/j.nutres.2008.01.008. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19083400.

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

In a randomized, double-blind study of 36 patients with type 2 diabetes or impaired glucose tolerance, hydrogen-rich water intake for 8 weeks significantly reduced oxidative stress markers, modified LDL cholesterol, and small dense LDL, while improving glucose tolerance in some patients. These findings suggest that hydrogen-rich water may help prevent type 2 diabetes and improve insulin resistance.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0271531708000237?via%3Dihub.
Ostojic SM. “Effects of hydrogen-rich water on prolonged intermittent exercise.” Nutrition Research, 2012;32(12):956-965. doi:10.1016/j.nutres.2012.09.004. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23107885.

Effects of hydrogen-rich water on prolonged intermittent exercise

In a study of 8 trained male cyclists, 2 weeks of hydrogen-rich water (HRW) intake maintained peak power output during repeated sprints, while placebo water led to a decrease in performance. HRW also helped stabilize acid-base balance, suggesting it could enhance endurance and performance in intermittent exercise.

You can read the full article at https://www.minervamedica.it/en/journals/sports-med-physical-fitness/article.php?cod=R40Y2018N05A0612.
Song G, et al. “Consumption of hydrogen-rich water reduces hepatic lipid accumulation in db/db mice.” Molecular and Cellular Biochemistry, 2013;373(1-2):21-30. doi:10.1007/s11010-012-1452-3. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23055154.

Consumption of hydrogen-rich water reduces hepatic lipid accumulation in db/db mice
A study investigated the effects of 28-day hydrogen-rich water (HRW) intake on liver fat, body composition, and lab profiles in overweight patients with mild-to-moderate non-alcoholic fatty liver disease (NAFLD). The double-blind, placebo-controlled trial found that HRW significantly reduced liver fat accumulation and serum aspartate transaminase levels, suggesting HRW as a potential adjuvant treatment for NAFLD. Further clinical trials are needed to confirm its safety and efficacy.
You can read the abstract of this article at
https://pubmed.ncbi.nlm.nih.gov/30982748/
Kamimura N, et al. “Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.” Obesity, 2011;19(7):1396-1403. doi:10.1038/oby.2011.6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21311510.

Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice

Recent studies show that drinking hydrogen-rich water (H₂-water) can reduce oxidative stress and improve conditions like obesity and type 2 diabetes. It enhances hepatic glycogen storage, which helps manage fatty liver and metabolic parameters, such as lowering glucose and triglyceride levels. This effect is linked to increased expression of the hormone FGF21, which boosts energy metabolism, suggesting potential benefits of H₂-water for metabolic syndrome.

You can read the full article at https://onlinelibrary.wiley.com/doi/10.1038/oby.2011.6.
Liu C, et al. “Hydrogen therapy may be a novel and effective treatment for diabetes and metabolic syndrome.” Diabetes Research and Clinical Practice, 2010;88(2):188-194. doi:10.1016/j.diabres.2010.02.023. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20303201.

Hydrogen therapy may be a novel and effective treatment for diabetes and metabolic syndrome
This retrospective study analyzed the effectiveness and safety of hydrogen inhalation (HI) therapy as an adjunct treatment in Chinese type 2 diabetes mellitus (T2DM) patients over six months. The study found that the HI group showed greater improvements in glycated hemoglobin (HbA1c), fasting plasma glucose, lipid profile, and insulin resistance compared to the control group, along with a lower incidence of adverse events like hypoglycemia and vomiting.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889559/.
Nakayama M, et al. “Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the Nrf2/ARE signaling pathway.” Neuroscience Letters, 2009;453(2):81-85. doi:10.1016/j.neulet.2009.01.008. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19141352.

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the Nrf2/ARE signaling pathway
Inhalation of molecular hydrogen (H2) gas and consumption of H2-saturated water reduce oxidative stress-induced brain injuries and prevent chronic neurodegenerative diseases. In cultured human neuroblastoma cells, H2 increases mitochondrial membrane potential and ATP levels, suggesting a protective role against oxidative stress. H2 functions as both a radical scavenger and a mitohormetic effector, enhancing resistance to oxidative stress through the Nrf2 pathway.
You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/28467497/.
Li J, et al. “Hydrogen-rich water protects against oxidative damage and cognitive deficits in an animal model of Alzheimer’s disease.” Neuroscience Letters, 2010;468(3):203-208. doi:10.1016/j.neulet.2009.10.052. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19854286.

Hydrogen-rich water protects against oxidative damage and cognitive deficits in an animal model of Alzheimer’s disease
Alzheimer’s disease, a common neurodegenerative disorder in the elderly, lacks effective treatment, but recent research highlights hydrogen’s potential therapeutic role due to its anti-oxidative and anti-inflammatory properties, which may protect neurons and slow disease progression.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352568/.
Mamiya T, et al. “Hydrogen-rich water protects against oxidative damage and improves memory function in a rat model of chronic stress.” Behavioural Brain Research, 2014;265:123-128. doi:10.1016/j.bbr.2014.02.041. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24631948.

Hydrogen-rich water protects against oxidative damage and improves memory function in a rat model of chronic stress
The study investigated the anti-inflammatory and anti-apoptotic effects of hydrogen-rich saline (HRS) on spinal cord injury in male Sprague Dawley rats. The results showed that HRS treatment significantly reduced levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), as well as decreased apoptosis, suggesting that HRS may be a potential adjuvant therapy for spinal cord injury.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143771/.
Hayashida K, et al. “Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.” Biochemical and Biophysical Research Communications, 2008;373(1):30-35. doi:10.1016/j.bbrc.2008.05.165. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18541154.

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury

Inhalation of hydrogen (H₂) gas shows promise in reducing ischemia-reperfusion injury, potentially offering cardioprotection during treatments like angioplasty for acute myocardial infarction. In studies with rats, H₂ gas improved recovery of heart function after anoxia-reoxygenation and reduced infarct size without affecting hemodynamic parameters, suggesting it could be a beneficial adjunct therapy during coronary artery recanalization.

You can read the abstract of the article at https://www.sciencedirect.com/science/article/abs/pii/S0006291X08010838.
Ohsawa I, et al. “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.” Nature Medicine, 2007;13(6):688-694. doi:10.1038/nm1577. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17486089.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Hydrogen (H₂) shows potential as an effective antioxidant for preventing and treating oxidative stress-related damage. It selectively reduces the highly toxic hydroxyl radical while sparing other reactive oxygen species with physiological roles. In studies with cultured cells and an acute rat model of brain ischemia-reperfusion, H₂ inhalation significantly mitigated oxidative stress and protected against tissue damage, highlighting its therapeutic potential in managing oxidative stress-related diseases.

You can read the abstract of the article at https://www.nature.com/articles/nm1577.
Sano M, et al. “Hydrogen-rich pure water prevents superoxide formation in brain slices from an Alzheimer’s disease model.” Neuroscience Research, 2008;62(4):212-217. doi:10.1016/j.neures.2008.09.003. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18854235.

Hydrogen-rich pure water prevents superoxide formation in brain slices from an Alzheimer’s disease model
Hydrogen-rich water, administered to vitamin C-deficient knockout mice, reduced superoxide formation in brain slices by 27.2% compared to pure water during ischemia-reperfusion, demonstrating its role as an antioxidant that prevents acute oxidative stress in the brain.
You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/18706888/.
Aoki K, et al. “Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.” Medical Gas Research, 2012;2:12. doi:10.1186/2045-9912-2-12. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2252083

Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

Hydrogen-rich water (HW) may help reduce oxidative stress and muscle fatigue from intense exercise. In a study with soccer players, HW prevented increases in blood lactate and maintained peak torque during exercise, unlike placebo water (PW), which led to muscle fatigue and elevated lactate levels. Although oxidative stress markers and creatine kinase levels remained unchanged, HW showed promise as a beneficial hydration option for athletes, warranting further investigation.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395574/.
Lee MY, et al. “Consumption of hydrogen-rich water reduces biomarkers of oxidative stress in patients with potential metabolic syndrome—an open label pilot study.” Journal of Clinical Biochemistry and Nutrition, 2011;46(2):140-149. doi:10.3164/jcbn.10-74. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21468014.

Consumption of hydrogen-rich water reduces biomarkes of oxidative stress in patients with potential metabolic syndrome—an open label pilot study
This study explored the effects of drinking 1.5-2 L/day of hydrogen-rich water for 8 weeks on 20 subjects with potential metabolic syndrome, finding significant increases in antioxidant enzyme levels and HDL-cholesterol, as well as a decrease in TBARS and total cholesterol/HDL-cholesterol ratio, suggesting it may be a novel therapeutic and preventive strategy for metabolic syndrome.
You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/20216947/.
Itoh Y, et al. “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: A randomized, double-blind, placebo-controlled study.” Medical Gas Research, 2011;1:12. doi:10.1186/2045-9912-1-12. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21575232.

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: A randomized, double-blind, placebo-controlled study
This study investigated the effects of drinking hydrogen-infused water on fatigue and endurance in both non-trained and trained participants during exercise. It found that consuming hydrogen water before exercise significantly reduced psychometric fatigue and improved endurance, as measured by visual analogue scales, maximal oxygen consumption, and Borg’s scale.
You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/31251888/.
Matsumoto A, et al. “Effects of Hydrogen-rich water on aging and longevity in mice.” Animal Science Journal, 2015;86(1):69-78. doi:10.1111/asj.12239. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25139619.

Effects of Hydrogen-rich water on aging and longevity in mice
This paper reviews the therapeutic potential of molecular hydrogen in combating aging and age-related diseases, highlighting its antioxidative effects, role in genomic stability, and regulation of inflammation and key biological processes like autophagy and apoptosis. Hydrogen shows promise in preventing and treating conditions such as neurodegenerative disorders, cardiovascular disease, and cancer.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956398/.
Nishimura N, et al. “Hydrogen-rich water reduces stress in rats by enhancing the antioxidant defense system.” Free Radical Research, 2016;50(5):431-442. doi:10.3109/10715762.2015.1128816. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26653877.

Hydrogen-rich water reduces stress in rats by enhancing the antioxidant defense system
This study investigated the effects of molecular hydrogen-rich water (HW) on muscle performance and oxidative stress during repeated sprint exercise. In a crossover trial with eight male volunteers, HW consumption prevented the decline in biological antioxidant potential and reduced oxidative damage compared to placebo water (PW). Although exercise performance did not differ between HW and PW conditions, HW helped maintain redox balance and might mitigate muscular fatigue during consecutive days of strenuous exercise.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871940/.
Kamimura N, et al. “Molecular hydrogen improves cognitive function in an aged mouse model.” PLoS ONE, 2017;12(8). doi:10.1371/journal.pone.0182925. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28813592.

Molecular hydrogen improves cognitive function in an aged mouse model
This study evaluated the effects of H2-water on oxidative stress in mice and individuals with mild cognitive impairment (MCI). Results showed that H2-water reduced oxidative stress and memory decline in mice, with increased lifespan. In a clinical trial, while overall cognitive scores in MCI patients did not differ significantly between H2-water and placebo groups, APOE4 carriers showed notable improvement in cognitive measures with H2-water, suggesting potential benefits for dementia management in specific genetic contexts.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872374/.
Ohta S. “Molecular hydrogen as a novel antioxidant: Overview of the advantages of hydrogen for medical applications.” Methods in Enzymology, 2015;555:289-317. doi:10.1016/bs.mie.2014.11.038. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25863301.

Molecular hydrogen as a novel antioxidant: Overview of the advantages of hydrogen for medical applications

Molecular hydrogen (H₂), once thought inert, has been shown to effectively neutralize harmful oxidants like hydroxyl radicals and peroxynitrite within cells without disrupting metabolic processes. It offers several advantages for medical applications due to its mild nature, efficient tissue diffusion, and minimal side effects. H₂ can be administered through various methods such as inhalation, ingestion, or injection, and has demonstrated potential as an anti-inflammatory, antiapoptotic, and energy-stimulating agent. Ongoing research supports its use in treating various diseases, highlighting its broad clinical potential.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0076687914001037?via%3Dihub.
Chen X, et al. “Hydrogen-rich saline attenuates cognitive impairment and hippocampal damage in a rat model of vascular dementia.” Neuroscience Letters, 2010;492(3):167-172. doi:10.1016/j.neulet.2011.01.040. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21241615.

Hydrogen-rich saline attenuates cognitive impairment and hippocampal damage in a rat model of vascular dementia
This study investigates the use of magnesium silicide nanosheets (MSNs) to efficiently deliver hydrogen, an antioxidant with potential benefits for vascular dementia (VaD). It finds that hydrogen improves cognitive function and reduces oxidative stress and inflammation in VaD rats, as evidenced by enhanced performance in memory tests and decreased levels of oxidative stress markers and inflammatory factors.
You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/38769944/.
Zheng Y, et al. “Hydrogen-rich water ameliorates cognitive impairment in a rat model of amyloid-beta-induced Alzheimer’s disease by suppressing oxidative stress.” Neuroscience Letters, 2013;549:202-207. doi:10.1016/j.neulet.2013.06.035. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23830943.

Hydrogen-rich water ameliorates cognitive impairment in a rat model of amyloid-beta-induced Alzheimer’s disease by suppressing oxidative stress
Alzheimer’s disease, a common neurodegenerative disorder characterized by cognitive decline and memory loss, currently lacks effective treatments. Recent research highlights hydrogen, a therapeutic gas with strong anti-oxidative and anti-inflammatory properties, as a promising candidate. Hydrogen has shown potential in reducing neuronal damage and slowing disease progression, making it a significant focus for new therapeutic strategies.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352568/.
Mizuno K, et al. “Hydrogen-rich water alleviates inflammatory bowel disease in mice by reducing oxidative stress and restoring gut microbiota balance.” PLoS ONE, 2017;12(3). doi:10.1371/journal.pone.0172418. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28267745.

Hydrogen-rich water alleviates inflammatory bowel disease in mice by reducing oxidative stress and restoring gut microbiota balance
This study investigated the impact of hydrogen-rich water (HRW) on chronic ulcerative colitis (UC) in mice. It found that HRW treatment alleviated UC symptoms, improved tissue damage, and reduced oxidative stress and inflammation by increasing glutathione levels and decreasing TNF-α. HRW also corrected intestinal dysbiosis by inhibiting the growth of harmful bacteria and altering gene expression related to inflammation.
You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/34784538/.
Buchholz BM, et al. “Hydrogen-enriched water inhibits inflammatory signaling and prevents apoptosis in pancreatic beta cells.” Biochemical and Biophysical Research Communications, 2011;414(2):283-289. doi:10.1016/j.bbrc.2011.09.090. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21945586.

Hydrogen-enriched water inhibits inflammatory signaling and prevents apoptosis in pancreatic beta cells

This review explores the emerging role of molecular hydrogen (H2) as a potential therapeutic agent for metabolic diseases, such as diabetes, metabolic syndrome, and obesity, highlighting its antioxidant, anti-inflammatory, and anti-apoptotic properties. It discusses the possible mechanisms through which H2 may exert these effects, including reducing oxidative stress and improving mitochondrial function, while noting that further high-quality clinical trials and research are needed to clarify its efficacy and mechanisms.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141176/
Noda K, et al. “The antioxidant effect of hydrogen-enriched water in hemodialysis patients.” Nephrology Dialysis Transplantation, 2012;27(8):3076-3084. doi:10.1093/ndt/gfs162. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22653982.

Chronic kidney disease (CKD) poses a significant public health challenge due to its associations with severe health issues like end-stage renal failure and cardiovascular diseases. Enhanced oxidative stress is a key factor in CKD, and electrolyzed hydrogen water (EHW) has shown promise as an antioxidant therapy. EHW, popular in Japan, has been found to mitigate kidney damage and systemic oxidative stress in CKD models and dialysis patients, potentially reducing cardiovascular complications. Further research into EHW’s medical benefits for CKD is warranted.
The antioxidant effect of hydrogen-enriched water in hemodialysis patients
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10812465/.
Kato S, et al. “Drinking hydrogen-rich water improves the quality of life in patients treated with radiotherapy for liver tumors.” Medical Gas Research, 2013;3:1-5. doi:10.1186/2045-9912-3-1. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23369513.

Drinking hydrogen-rich water improves the quality of life in patients treated with radiotherapy for liver tumors
A study on 49 cancer patients undergoing radiotherapy found that drinking hydrogen-rich water improved quality of life and reduced oxidative stress without affecting tumor response. The hydrogen-rich water reduced reactive oxygen metabolites and maintained antioxidant levels in the blood, suggesting it as a potential therapeutic strategy for enhancing patient well-being during radiotherapy.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231938/.
Kawamura T, et al. “Hydrogen-rich water improves endoplasmic reticulum stress-induced liver injury in mice.” Scientific Reports, 2012;2:5. doi:10.1038/srep00005. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22403732.

Hydrogen-rich water improves endoplasmic reticulum stress-induced liver injury in mice
This study evaluated the therapeutic effects of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) in mice, revealing that HRW significantly reduces weight loss, disease activity, colonic inflammation, and oxidative stress compared to controls. HRW treatment also improved histological damage and reduced inflammatory markers and endoplasmic reticulum stress, while up-regulating heme oxygenase-1 (HO-1). The presence of ZnPP, a HO-1 inhibitor, reversed these protective effects, highlighting HRW’s potential in managing IBD.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330822/.
Li S, et al. “Hydrogen-rich saline reduces cell death and attenuates early brain injury after subarachnoid hemorrhage in rats.” Critical Care Medicine, 2011;39(11):2189-2198. doi:10.1097/CCM.0b013e318222. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21897240.

Hydrogen-rich saline reduces cell death and attenuates early brain injury after subarachnoid hemorrhage in rats
This study explores hydrogen-rich saline’s neuroprotective effects in a mouse model of subarachnoid hemorrhage (SAH), focusing on its impact on early brain injury (EBI) through regulation of autophagy and endoplasmic reticulum (ER) stress. Findings indicate that hydrogen-rich saline improves survival rates, neurological scores, and neuron survival by reducing autophagy and ER stress, with its effects partly mediated by the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516430/.
Itoh T, et al. “Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydroxydopamine-induced Parkinson’s disease in rats.” Medical Gas Research, 2012;2:15. doi:10.1186/2045-9912-2-15. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22608007.

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydroxydopamine-induced Parkinson’s disease in rats

Lactulose and hydrogen water both increase breath hydrogen levels, with lactulose having a marginal effect on Parkinson’s disease (PD) in rats, while hydrogen water showed more significant impact. Continuous hydrogen gas administration had limited effects, but intermittent hydrogen gas effectively prevented PD in a majority of rats. These findings suggest that intermittent hydrogen gas administration and hydrogen water may have protective effects against PD, likely due to their ability to modulate signaling pathways.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407490/.
Ito M, et al. “Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice.” Journal of Clinical Biochemistry and Nutrition, 2011;49(3):182-187. doi:10.3164/jcbn.11-29. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21994554.

Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

Drinking hydrogen water for 30 days prevented spatial memory decline and age-related brain changes in senescence-accelerated prone mouse 8 (SAMP8) models. The treatment improved cognitive function, increased brain serotonin levels, and elevated serum antioxidant activity, while inhibiting neurodegeneration in the hippocampus compared to control mice. These findings suggest hydrogen water could be a promising therapeutic or preventive treatment for age-related cognitive disorders.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872234/.
Oharazawa H, et al. “Hydrogen-rich water prevents progression of diabetic retinopathy in streptozotocin-induced diabetic rats.” PLoS ONE, 2010;5(5). doi:10.1371/journal.pone.0018889. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20503228.

Hydrogen-rich water prevents progression of diabetic retinopathy in streptozotocin-induced diabetic rats
This study investigates the potential of hydrogen to alleviate diabetic peripheral neuropathy (DPN) in diabetic rats, finding that hydrogen inhalation significantly reduces blood glucose levels, improves nerve function, and lowers oxidative stress. It works by enhancing antioxidant defenses through the nuclear factor erythroid-2-related factor 2 pathway, indicating its promising clinical potential for treating DPN.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555025/.
Yoritaka A, et al. “Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial.” Movement Disorders, 2013;28(6):836-839. doi:10.1002/mds.25375. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23436650.

Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial

In a 48-week clinical pilot study, Japanese patients with Parkinson’s disease who drank 1,000 mL/day of hydrogen-dissolved water (H₂-water) showed a significant improvement in Unified Parkinson’s Disease Rating Scale (UPDRS) scores compared to those who drank placebo water. Despite the small sample size and short duration, H₂-water was found to be safe and well tolerated, suggesting its potential benefit in managing Parkinson’s disease symptoms.

You can read the abstract of the article at https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.25375.
Hara F, et al. “Hydrogen-rich water attenuates acrolein-induced neurotoxicity and cognitive impairment: Role of mitochondrial function.” Journal of Alzheimer’s Disease, 2015;48(1):27-39. doi:10.3233/JAD-150394. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26401792.

Hydrogen-rich water attenuates acrolein-induced neurotoxicity and cognitive impairment: Role of mitochondrial function
This study explored the effects of molecular hydrogen treatment on cerebral ischemia-reperfusion injury in mice, demonstrating improved cognitive function, reduced anxiety, and antioxidative and antiapoptotic effects. Hydrogen treatment also decreased pro-inflammatory markers Bax and TNFα and regulated IL-2 and IL-10 levels, suggesting potential as a therapeutic strategy for neurodegenerative diseases.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566066/.
Naito Y, et al. “Oral administration of hydrogen-rich water ameliorates collagen-induced arthritis in mice.” Biochemical and Biophysical Research Communications, 2016;460(3):820-825. doi:10.1016/j.bbrc.2015.12.070. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26721550.

Oral administration of hydrogen-rich water ameliorates collagen-induced arthritis in mice
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD), a major mortality cause in RA patients, has limited treatments. A study using D1CC transgenic mice, which develop RA-like symptoms and interstitial pneumonitis, investigated the effects of molecular hydrogen (H2) treatment. H2, an antioxidant, reduced oxidative stress and alleviated inflammatory and fibrotic changes in the lungs, suggesting its potential protective role against RA-ILD.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787460/.
Oda K, et al. “Hydrogen-rich water ameliorates oxidative stress and microcirculatory impairment in a rat model of pressure ulcer.” PLoS ONE, 2015;10(4). doi:10.1371/journal.pone.0124901. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25890340.

Hydrogen-rich water ameliorates oxidative stress and microcirculatory impairment in a rat model of pressure ulcer
This study investigates the protective effects of hydrogen-rich water (HW) on lipid and glucose metabolism, oxidative stress, and inflammation in type 2 diabetes mellitus (T2DM) rats, finding that HW reduces glucose, cholesterol, oxidative stress, and inflammation, and improves organ function.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33830396/
Buchholz BM, et al. “Hydrogen-enriched water ameliorates inflammatory bowel disease in mice.” Journal of Clinical Biochemistry and Nutrition, 2011;49(3):182-187. doi:10.3164/jcbn.11-29. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22041042.

Hydrogen-enriched water ameliorates inflammatory bowel disease in mice

This study explored the therapeutic effects of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) in mice, demonstrating that HRW significantly alleviates symptoms, reduces inflammation, oxidative stress, and ER stress, and increases HO-1 expression. The findings suggest HRW’s potential in treating IBD by targeting these mechanisms.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330822/
Sun Q, et al. “Hydrogen-rich saline suppresses mitochondrial oxidative stress in a rat model of amyloid-beta-induced Alzheimer’s disease.” Neuroscience Letters, 2012;492(3):167-172. doi:10.1016/j.neulet.2011.01.040. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21241615.

Hydrogen-rich saline suppresses mitochondrial oxidative stress in a rat model of amyloid-beta-induced Alzheimer’s disease

This study investigated whether hydrogen-rich saline could reduce amyloid beta-induced neural inflammation and cognitive deficits in rats. It found that hydrogen-rich saline treatment decreased levels of MDA, IL-6, and TNF-alpha, improved performance in memory and motor function tests, enhanced LTP, and reduced oxidative stress and glial cell activation, suggesting a protective effect against neuroinflammation and oxidative stress.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/20171955/.
Itoh Y, et al. “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: A randomized, double-blind, placebo-controlled study.” Medical Gas Research, 2011;1:12. doi:10.1186/2045-9912-1-12. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21575232.

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: A randomized, double-blind, placebo-controlled study

This study explored the effects of drinking hydrogen-infused water on fatigue and endurance in a randomized, double-blind, placebo-controlled trial. Healthy participants who consumed the water showed reduced psychometric fatigue and increased endurance during exercise, with greater benefits observed in those with higher initial fatigue levels. The results suggest hydrogen water may have anti-fatigue and endurance-enhancing properties.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/31251888/.
Matsumoto A, et al. “Effects of hydrogen-rich water on aging and longevity in mice.” Animal Science Journal, 2015;86(1):69-78. doi:10.1111/asj.12239. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25139619.

Effects of hydrogen-rich water on aging and longevity in mice

Aging is a natural decline in bodily functions and a risk factor for chronic diseases. Molecular hydrogen has therapeutic effects due to its antioxidative properties, which help neutralize harmful radicals, maintain genomic stability, and regulate cellular processes. It may prevent inflammation and affect aging-related factors like the mTOR system, autophagy, and mitochondria, offering potential treatment for diseases such as neurodegenerative disorders, cardiovascular disease, and cancer. This paper reviews research on hydrogen’s medical use for aging prevention and therapy.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956398/.
Nishimura N, et al. “Hydrogen-rich water reduces stress in rats by enhancing the antioxidant defense system.” Free Radical Research, 2016;50(5):431-442. doi:10.3109/10715762.2015.1128816. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26653877.

Hydrogen-rich water reduces stress in rats by enhancing the antioxidant defense system
A single-blind, crossover randomized controlled trial examined the effects of molecular hydrogen-rich water (HW) on muscle performance and oxidative stress during repeated sprint exercise. Eight male participants performed a series of exercises over three days, consuming either HW or placebo water (PW) before and after. The study found that while exercise performance was similar in both conditions, HW helped maintain redox status and potentially prevented accumulative muscular fatigue, unlike PW, which showed a gradual decrease in systemic antioxidant potential.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871940/.
Kamimura N, et al. “Molecular hydrogen improves cognitive function in an aged mouse model.” PLoS ONE, 2017;12(8). doi:10.1371/journal.pone.0182925. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28813592.

Molecular hydrogen improves cognitive function in an aged mouse model
This study explores the effects of drinking hydrogen-infused water (H2-water) on oxidative stress in a mouse model and subjects with mild cognitive impairment (MCI). In mice, H2-water reduced oxidative stress and memory decline, while in MCI subjects, it showed significant cognitive improvement in carriers of the APOE4 genotype. H2-water may help suppress dementia-related symptoms associated with oxidative stress.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/29110615/.
Song G, et al. “Consumption of hydrogen-rich water reduces hepatic lipid accumulation in db/db mice.” Molecular and Cellular Biochemistry, 2013;373(1-2):21-30. doi:10.1007/s11010-012-1452-3. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23055154.

Consumption of hydrogen-rich water reduces hepatic lipid accumulation in db/db mice
This study investigated the effects of hydrogen-rich water (HRW) on liver fat and body composition in overweight patients with mild-to-moderate non-alcoholic fatty liver disease (NAFLD). Over 28 days, HRW significantly reduced liver fat accumulation and lowered serum aspartate transaminase levels compared to a placebo, although no significant changes were observed in body weight or composition. These results suggest HRW may be a promising adjunctive treatment for NAFLD, warranting further research.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/30982748/.
Chen X, et al. “Hydrogen-rich saline attenuates cognitive impairment and hippocampal damage in a rat model of vascular dementia.” Neuroscience Letters, 2010;492(3):167-172. doi:10.1016/j.neulet.2011.01.040. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21241615.

Hydrogen-rich saline attenuates cognitive impairment and hippocampal damage in a rat model of vascular dementia

This study explored the potential of molecular hydrogen as a treatment for cerebral ischemia-reperfusion injury in mice. Hydrogen-rich water improved cognitive function, reduced cell apoptosis, and enhanced antioxidant and anti-inflammatory responses. Behavioral tests and biochemical analyses showed that hydrogen treatment mitigated damage and improved outcomes compared to untreated controls, suggesting its promise as a therapeutic strategy for neurodegenerative diseases.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566066/.
Hayashida K, et al. “Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.” Biochemical and Biophysical Research Communications, 2008;373(1):30-35. doi:10.1016/j.bbrc.2008.05.165. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18541154.

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
Inhalation of hydrogen gas (H₂) shows promise in reducing ischemia-reperfusion injury in myocardial infarction by limiting infarct size and improving left ventricular function in rats. The therapy helps prevent damage to the heart muscle during the critical period before blood flow is restored, offering a potential adjunct to coronary artery recanalization.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/18541148/.
Itoh Y, et al. “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: A randomized, double-blind, placebo-controlled study.” Medical Gas Research, 2011;1:12. doi:10.1186/2045-9912-1-12. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21575232.

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: A randomized, double-blind, placebo-controlled study

Drinking hydrogen-infused water (H2 water) before exercise was found to significantly reduce psychometric fatigue and improve endurance in both untrained and trained participants. In controlled trials, H2 water decreased fatigue and enhanced performance compared to placebo, highlighting its potential benefits for exercise-related fatigue and endurance.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/31251888/.
Liu C, et al. “Hydrogen therapy may be a novel and effective treatment for diabetes and metabolic syndrome.” Diabetes Research and Clinical Practice, 2010;88(2):188-194. doi:10.1016/j.diabres.2010.02.023. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20303201.

This observational study assessed hydrogen inhalation (HI) therapy as an adjunct treatment for type 2 diabetes in a real-world clinical setting. Over 6 months, HI therapy significantly improved glycated hemoglobin, fasting plasma glucose, cholesterol levels, and insulin resistance compared to conventional treatment alone. Additionally, HI therapy was associated with a lower incidence of adverse events, such as hypoglycemia and vomiting, suggesting it enhances glycemic control and safety for diabetic patients.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889559/.
Kamimura N, et al. “Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.” Obesity, 2011;19(7):1396-1403. doi:10.1038/oby.2011.6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21311510.

Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice
Recent studies show that molecular hydrogen (H₂) can effectively improve oxidative stress-related diseases through various methods, including inhalation, injection, or drinking H₂-enriched water. This research highlights that H₂ accumulates in hepatic glycogen after oral ingestion and demonstrates that drinking H₂-enriched water reduces oxidative stress, fatty liver, and body fat in type 2 diabetes mouse models. It also improves metabolic parameters by enhancing the expression of the hepatic hormone FGF21 and stimulating energy metabolism, suggesting potential benefits for obesity, diabetes, and metabolic syndrome.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/21293445/.
Nakayama M, et al. “Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the Nrf2/ARE signaling pathway.” Neuroscience Letters, 2009;453(2):81-85. doi:10.1016/j.neulet.2009.01.008. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19141352.

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the Nrf2/ARE signaling pathway
Inhalation of molecular hydrogen (H2) gas and consumption of H2-saturated water reduce oxidative stress and protect against neurodegenerative diseases. Studies on neuroblastoma cells show that H2 enhances mitochondrial function and ATP levels, decreases glutathione, and increases superoxide levels. H2 pretreatment reduces cell death from oxidative stress and boosts anti-oxidative enzyme expression through the Nrf2 pathway, suggesting it acts as both a radical scavenger and a mitohormetic agent.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/28467497/.
Li J, et al. “Hydrogen-rich water protects against oxidative damage and cognitive deficits in an animal model of Alzheimer’s disease.” Neuroscience Letters, 2010;468(3):203-208. doi:10.1016/j.neulet.2009.10.052. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19854286.

Hydrogen-rich water protects against oxidative damage and cognitive deficits in an animal model of Alzheimer’s disease
Alzheimer’s disease, a prevalent neurodegenerative condition in the elderly with no effective treatment, is being studied for potential benefits from hydrogen therapy. Hydrogen, known for its antioxidant and anti-inflammatory properties, has shown promise in reducing neuronal damage and slowing disease progression in cerebral models. This paper explores hydrogen’s therapeutic potential and mechanisms in treating Alzheimer’s disease.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352568/.
Mamiya T, et al. “Hydrogen-rich water protects against oxidative damage and improves memory function in a rat model of chronic stress.” Behavioural Brain Research, 2014;265:123-128. doi:10.1016/j.bbr.2014.02.041. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24631948.

Hydrogen-rich water protects against oxidative damage and improves memory function in a rat model of chronic stress
The study investigated the effects of hydrogen-rich saline (HRS) on spinal cord injury in rats, revealing that HRS treatment reduced inflammation and apoptosis compared to untreated spinal injuries. Specifically, levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were lower, and decreased apoptosis was observed in the HRS-treated group, suggesting HRS may be a beneficial adjunct therapy for spinal cord injuries.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143771/.
Noda K, et al. “The antioxidant effect of hydrogen-enriched water in hemodialysis patients.” Nephrology Dialysis Transplantation, 2012;27(8):3076-3084. doi:10.1093/ndt/gfs162. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22653982.

The antioxidant effect of hydrogen-enriched water in hemodialysis patients
Hydrogen, still underutilized in medicine, shows promising pharmacological effects such as antioxidant, anti-inflammatory, and antiapoptotic properties. It can be administered in various forms and selectively scavenges harmful radicals without affecting beneficial ones. Despite its therapeutic potential, especially for renal diseases, more large-scale clinical trials are needed to establish its efficacy and optimal use.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021642/.
Kawamura T, et al. “Hydrogen-rich water improves endoplasmic reticulum stress-induced liver injury in mice.” Scientific Reports, 2012;2:5. doi:10.1038/srep00005. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22403732.

This study investigated the effects of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) in mice, finding that HRW significantly reduced weight loss, colonic inflammation, and oxidative stress while improving protective indicators and decreasing inflammatory factors. The treatment also lowered endoplasmic reticulum stress markers and increased heme oxygenase-1 expression. Co-treatment with a heme oxygenase-1 inhibitor (ZnPP) reversed these benefits, highlighting HRW’s potential in IBD therapy through its anti-inflammatory, antioxidant, and stress-reducing effects.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330822/.
Kato S, et al. “Drinking hydrogen-rich water improves the quality of life in patients treated with radiotherapy for liver tumors.” Medical Gas Research, 2013;3:1-5. doi:10.1186/2045-9912-3-1. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23369513.

Drinking hydrogen-rich water improves the quality of life in patients treated with radiotherapy for liver tumors
A study evaluated the impact of hydrogen-rich water on quality of life (QOL) in 49 cancer patients undergoing radiotherapy. The results showed that drinking hydrogen-rich water reduced oxidative stress and improved QOL without affecting tumor response. This suggests that hydrogen-rich water could be a promising method to alleviate radiotherapy-related fatigue and improve overall well-being.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231938/.
Itoh M, et al. “Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice.” Journal of Clinical Biochemistry and Nutrition, 2011;49(3):182-187. doi:10.3164/jcbn.11-29. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21994554.

Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice
This study explored the potential of hydrogen water to prevent cognitive decline and age-related brain changes in aging mice. Findings show that hydrogen water improved spatial memory, increased brain serotonin levels, and boosted antioxidant activity. It also reduced neurodegeneration in the hippocampus compared to control mice, suggesting hydrogen water may be beneficial for age-related cognitive disorders and warrants further research.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/20490324/.
Oharazawa H, et al. “Hydrogen-rich water prevents progression of diabetic retinopathy in streptozotocin-induced diabetic rats.” PLoS ONE, 2010;5(5). doi:10.1371/journal.pone.0018889. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20503228.

Hydrogen-rich water prevents progression of diabetic retinopathy in streptozotocin-induced diabetic rats
This paper investigates the potential of hydrogen therapy in reducing diabetic peripheral neuropathy (DPN) in diabetic rats. It finds that hydrogen inhalation, compared to hydrogen-rich saline, significantly lowers blood glucose levels and improves nerve function by reducing oxidative stress and enhancing antioxidant capabilities. The study suggests that hydrogen’s protective effects are mediated through the nuclear factor erythroid-2-related factor 2 pathway, highlighting its potential clinical value.

You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555025/.
Yoritaka A, et al. “Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial.” Movement Disorders, 2013;28(6):836-839. doi:10.1002/mds.25375. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23436650.

Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial
A pilot study found that drinking 1,000 mL/day of H₂-dissolved water (H₂-water) significantly improved Parkinson’s disease symptoms, as measured by the Unified Parkinson’s Disease Rating Scale, compared to a placebo in Japanese patients on levodopa medication. Despite the small sample size and short duration, H₂-water was safe, well tolerated, and showed promising results in reducing Parkinson’s features.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/23400965/.
Hara F, et al. “Hydrogen-rich water attenuates acrolein-induced neurotoxicity and cognitive impairment: Role of mitochondrial function.” Journal of Alzheimer’s Disease, 2015;48(1):27-39. doi:10.3233/JAD-150394. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26401792.

Hydrogen-rich water attenuates acrolein-induced neurotoxicity and cognitive impairment: Role of mitochondrial function
This study investigates the potential of hydrogen treatment for mitigating cerebral ischemia-reperfusion injury and its related neurodegenerative effects. Mice with induced ischemia-reperfusion injury showed improved cognitive function, reduced cell death, and enhanced antioxidative and anti-inflammatory responses after hydrogen-rich water treatment. These findings suggest that hydrogen may be a promising therapeutic strategy for neurodegenerative diseases associated with ischemia.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566066/.
Naito Y, et al. “Oral administration of hydrogen-rich water ameliorates collagen-induced arthritis in mice.” Biochemical and Biophysical Research Communications, 2016;460(3):820-825. doi:10.1016/j.bbrc.2015.12.070. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26721550.

In a study using D1CC transgenic mice, which model rheumatoid arthritis (RA) and associated interstitial lung disease (ILD), researchers found that molecular hydrogen (H2) treatment reduced inflammation and fibrosis in the lungs. The study demonstrated that H2 alleviates oxidative stress and mitigates chronic lung damage, making it a promising candidate for treating RA-ILD.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787460/.
Oda K, et al. “Hydrogen-rich water ameliorates oxidative stress and microcirculatory impairment in a rat model of pressure ulcer.” PLoS ONE, 2015;10(4). doi:10.1371/journal.pone.0124901. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25890340.

Hydrogen-rich water ameliorates oxidative stress and microcirculatory impairment in a rat model of pressure ulcer
This study investigates the effects of hydrogen-rich water (HW) on lipid and glucose metabolism, oxidative stress, and inflammation in type 2 diabetes mellitus (T2DM) rats. Results show that HW supplementation significantly reduces glucose levels, total cholesterol, oxidative stress, and inflammation, and improves liver, kidney, and spleen function in T2DM rats, suggesting potential benefits for T2DM patients.

You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33830396/.
Buchholz BM, et al. “Hydrogen-enriched water ameliorates inflammatory bowel disease in mice.” Journal of Clinical Biochemistry and Nutrition, 2011;49(3):182-187. doi:10.3164/jcbn.11-29. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22041042.

Hydrogen-enriched water ameliorates inflammatory bowel disease in mice
You can read the abstract of the article at
This study explores hydrogen-rich water (HRW) as a potential treatment for inflammatory bowel disease (IBD) in mice, finding that HRW significantly reduces weight loss, inflammation, and oxidative stress while improving colon health. HRW’s effects are linked to decreased inflammatory markers, reduced endoplasmic reticulum stress, and increased heme oxygenase-1 expression. The addition of a heme oxygenase-1 inhibitor, ZnPP, negates the benefits of HRW, highlighting its role in the observed therapeutic effects.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330822/.
Sun Q, et al. “Hydrogen-rich saline suppresses mitochondrial oxidative stress in a rat model of amyloid-beta-induced Alzheimer’s disease.” Neuroscience Letters, 2012;492(3):167-172. doi:10.1016/j.neulet.2011.01.040. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21241615.

Hydrogen-rich saline suppresses mitochondrial oxidative stress in a rat model of amyloid-beta-induced Alzheimer’s disease
This study investigates the effects of hydrogen-rich saline on amyloid beta-induced neural inflammation and cognitive deficits in rats. It found that hydrogen-rich saline treatment reduced levels of oxidative stress markers and inflammatory cytokines, improved memory performance in the Morris Water Maze, and enhanced long-term potentiation in the hippocampus, suggesting it may counteract the neuroinflammation and oxidative stress associated with amyloid beta.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/20171955/.

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