GENEMEDICS APP

GENEMEDICS NUTRITION

5-amino-1MQ

Author: Dr. George Shanlikian, M.D.  |   Last Updated: January 30th, 2024

Share This Page

Book a Free Consultation

Potential Benefits of 5-amino-1MQ

5-amino-1MQ offers a range of notable benefits, including producing dramatic weight loss, lowering cholesterol levels, and improving blood sugar levels, making it potentially valuable for metabolic health. Moreover, it demonstrates anti-inflammatory properties and shows promise in combating various cancer types, suggesting potential applications in both cancer therapy and inflammation-related conditions. Additionally, it enhances aged muscle regeneration, highlighting its potential in promoting muscle health and function.

  • Produces dramatic weight loss [1-10]
  • Lowers cholesterol levels [3, 11]
  • Improves blood sugar levels [3, 12-17]
  • Fights inflammation [18-22]
  • Combats various cancer types [23-37]
  • Enhances aged muscle regeneration [38-41]

What is 5-amino-1MQ?

Obesity may significantly impact one’s quality of life, as it can negatively affect independent movement and exercise. While this condition can cause physical and emotional problems, it can also increase one’s risk for deadly diseases such as heart disease, diabetes, cancer, stroke, and non-alcoholic liver failure.

When fat cells grow larger as we gain weight, it causes excess production of NNMT (Nicotinamide N-methyltransferase), a cytosolic enzyme that slows down fat cell metabolism and is predominantly active in fat tissue. Excess production of NNMT can lead to alterations in the body’s metabolism and the regulation of energy balance, potentially contributing to weight gain. In addition, more hormones and pro-inflammatory signals associated with weight gain are produced with increased fat tissue. Therefore, body fat accumulates over time and becomes very challenging to remove without surgical intervention.

Recently, a new breakthrough may help patients with this severe form of obesity achieve a healthier weight. The NNMT inhibitor 5-amino-1-methylquinoline or 5-amino-1MQ has been shown to reduce the production of the enzyme nicotinamide N-methyltransferase (NNMT), a regulator of energy homeostasis in adipose tissue (a type of fat used for energy storage). This mechanism could shrink white adipose tissue and dramatically reduce weight without the need to limit calorie intake. Studies show that there are far more potential benefits of 5-amino-1MQ than just weight loss.

How 5-amino-1MQ Works

5-amino-1MQ, a small, selective, membrane-permeable molecule, blocks the activity of an enzyme in the metabolic cycles called nicotinamide N-methyltransferase (NNMT). This process increases nicotinamide adenine dinucleotide (NAD+), which is involved in a wide array of cellular reactions. The increase in NAD+ levels also increases the body’s metabolic rate, resulting in weight loss. In addition, a gene called sirtuin-1 (SIRT1), also known as ‘the longevity gene’, is also activated. SIRT1 helps lower the risk of debilitating diseases such as diabetes, cardiovascular disease, sleep apnea, and cancer.

Diagram illustrating the mechanism of action of 5-amino-1MQ (5-amino-1-methylquinolinium) with labels and arrows depicting its interaction with cellular components and its effects.

Chemical Structure of 5-amino-1MQ

A small molecule drug called 5-amino-1MQ.

Research on 5-amino-1MQ

A. Produces Dramatic Weight Loss

Image of a woman's abdomen with a tape measure, symbolizing weight loss and fitness progress.

5-amino-1MQ has been demonstrated to target and stimulate brown adipose tissue (BAT) activity, a critical player in fat cell metabolism and thermogenesis, responsible for burning stored fat to generate heat. Through a process known as browning, 5-amino-1MQ triggers the conversion of white fat cells into beige fat cells, enhancing their ability to burn fat and thus effectively promoting weight loss. This browning effect not only aids in reducing weight gain but also contributes to the overall shrinkage of fat cells within the body’s fat tissue, thus reducing fat stores.

Furthermore, 5-amino-1MQ has been shown to potentially enhance the basal metabolic rate, which can contribute to increased calorie burning and, consequently, support weight loss efforts. Therefore, 5-amino-1MQ emerges as a promising strategy for reversing obesity and related metabolic disorders, offering a potential means to lose weight and improve fat cell metabolism.

Evidence suggests that by shrinking fat cells, 5-amino-1MQ can significantly reduce weight, burn fat, and improve body composition:

  1. In U.S. Veterans military service members, the administration of 5-amino-1MQ resulted in significant weight loss without any adverse side effects. [1]
  2. In diet-induced obese mice that were maintained on a high-fat diet, the administration of an NNMT inhibitor significantly reduced body weight and white adipose tissue mass and decreased the size of adipocyte cells (cells specialized for fat storage) without any observable adverse effects, suggesting enhanced cellular metabolism of adipocytes. [2-3]
  3. The administration of an NNMT inhibitor in mice on a high-fat diet (HFD) protected against fat accumulation and weight gain by augmenting cellular energy expenditure. [4]
  4. Studies also showed that NNMT is increased 2-fold in the subcutaneous and abdominal adipose tissue of men and women with type II diabetes compared to healthy subjects, suggesting that the administration of NNMT inhibitors may burn fat and lose weight. [5-7]
  5. A cell study found that 5-amino-1MQ was able to prevent fat accumulation and shrink fat cells, resulting in less fat tissue. [8]
  6. Studies found that high levels of NNMT were often found in fat cells and were associated with impaired calorie utilization resulting in increased fat storage – a mechanism related to weight gain. [9-10]

Unlock Your Weight Loss Potential with Peptides! Discover the science-backed power of peptides for weight loss.

B. Lowers Cholesterol Levels

Cholesterol Level Meter: Monitoring and Managing Cholesterol Levels for Better Health.

5-amino-1MQ can help lower cholesterol levels by increasing the production of NAD+ in our cells and activating the SIRT1 gene. When NAD+ levels rise, it promotes the activity of SIRT1, a gene that plays a key role in regulating our body’s metabolism. SIRT1 helps in breaking down cholesterol and reducing its buildup in the bloodstream, which ultimately leads to lower cholesterol levels. This can help lower the risk of chronic diseases such as coronary heart disease, kidney disease, and high blood pressure.

Studies show that 5-amino-1MQ’s ability to increase NAD+ and activate the SIRT1 gene can help improve cholesterol levels:

  1. In diet-induced obese (DIO) mice maintained on a high-fat diet, the administration of an NNMT inhibitor lowered plasma total cholesterol levels. [3]
  2. A study found that SIRT1 activation by 5-amino-1MQ resulted in the suppression of cholesterol synthesis. [11]

C. Improves Blood Sugar Levels

Image of a man's hands using a glucometer to measure blood sugar levels for diabetes management.

5-amino-1MQ can lower blood sugar levels by improving the body’s ability to use sugar more effectively. It does this by improving the way cells in the body respond to insulin, which is a hormone that regulates blood sugar. When cells become more responsive to insulin, they can take in and use sugar from the blood more efficiently, leading to lower blood sugar levels. This effect can be particularly helpful for people with conditions like type II diabetes, where blood sugar regulation is a concern, as it can contribute to better overall blood sugar control.

Evidence found that 5-amino-1MQ has beneficial effects on blood sugar levels:

  1. In diet-induced obese (DIO) mice maintained on a high-fat diet, the administration of a potent NNMT inhibitor dramatically reduced blood sugar levels without altering food intake and without adverse side effects. [3]
  2. Several studies found that NNMT plays a causative role in the development of type 2 diabetes and insulin resistance, suggesting that NNMT inhibitors may help lower the risk of the disease. [12-16]
  3. In mice, 5-amino-1MQ altered how fat cells work leading to the production of palmitic acid esters of hydroxy-stearic acids (PAHSAs), a class of lipids that can reduce insulin resistance. [17]

D. Fights Inflammation

Inflammation in Human Body - Glowing Joints Illustration.

5-amino-1MQ can help combat inflammation by acting as an anti-inflammatory agent. It does this by reducing the production and release of molecules in the body that promote inflammation. This, in turn, helps to calm down the body’s inflammatory response and prevent it from becoming overly active. As a result, 5-amino-1MQ contributes to the reduction of inflammation, which is associated with various health issues, including chronic conditions.

Evidence suggests that the enzyme NNMT is highly associated with inflammatory conditions and related injuries, suggesting that NNMT inhibitors like 5-amino-1MQ may have anti-inflammatory effects:

  1. Significantly increased levels of NNMT have been observed in the lungs and skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) with muscle wasting. [18-19]
  2. Experimental studies in mice also found an increase in NNMT levels after drug-induced liver injury. [20-21]
  3. A study found that NNMT production is the body’s protective compensatory response to injury, resulting in inflammatory states. [22]

E. Combats Various Cancer Types

Image depicting different types of cancer cells, their formation process, and key characteristics.

5 amino 1MQ cancer-fighting properties are attributed to the peptide’s ability to disrupt the energy supply to cancer cells, making it difficult for them to grow and spread. Cancer cells often rely heavily on a process called glycolysis to fuel their rapid growth. 5-amino-1MQ interferes with this process, reducing the availability of glucose, a key energy source for cancer cells. This disruption can slow down cancer cell growth and make them more vulnerable to other treatments, potentially enhancing the effectiveness of cancer therapies and contributing to the fight against cancer.

A number of high-quality studies also suggest that excess NNMT is strongly linked with the development of various types of cancer, suggesting a potential therapeutic role for NNMT inhibitors:

  1. NNMT levels are significantly increased in primary glioblastoma tumors (aggressive brain tumors) compared to normal human brain samples. [23]
  2. Enhanced NNMT production is also increased in human papillary thyroid cancer cell lines. [24]
  3. In renal clear cell carcinoma, the production of NNMT is also significantly increased. [25]
  4. In human bladder cancer, NNMT was found to be a major regulator of cell migration. [26]
  5. The NNMT protein is also increased in gastric cancers. [27-28]
  6. NNMT is also identified as a novel serum tumor marker for human colorectal cancers and oral squamous cell carcinoma. [29-30]
  7. NNMT knockdown (NNMT gene loss) decreased the proliferation and migration of bladder cancer cells. [31]
  8. NNMT knockdown also inhibited the proliferation and/or metastasis of kidney cancer cells, pancreatic cancer cells, and oral squamous carcinoma. [32-34]
  9. In non-small-cell lung cancer cells, inhibition of NNMT production resulted in suppression of tumor growth. [35]
  10. Higher levels of NNMT in tumor tissues are associated with lower overall survival rates in cancer patients, suggesting that NNMT inhibitor administration may help improve survival. [36]
  11. In a human oral cancer cell line, the administration of an NNMT inhibitor dramatically reduced cancer cell growth and reproduction. [37]

F. Enhances Aged Muscle Regeneration

Side-by-side comparison of young muscle tissue (left) and aged muscle (right), highlighting differences in muscle fiber size, density, and structural integrity.

5-amino 1MQ helps reverse the decline in aged muscle regeneration and promotes muscle mass by boosting the activity of satellite cells, which are essential for muscle repair and growth. In aged muscles, these satellite cells become less active, leading to muscle loss and weakness. 5-amino-1MQ rejuvenates these cells, enhancing their ability to repair and replace damaged muscle fibers. This results in improved muscle regeneration and an increase in muscle mass over time. As a result, 5-amino-1MQ holds promise as a potential solution for combating the muscle loss commonly associated with aging.

Studies suggest that 5-amino-1MQ and other NNMT inhibitors have anti-aging effects on the muscles:

  1. In old mice (24 months) with acute muscle injury due to barium chloride injection, the NNMT inhibitor-treated group exhibited greater contractile function (indicative of improved muscle function) compared to the saline-treated group. [38]
  2. In a mouse model of muscular dystrophy (progressive weakness and loss of muscle mass), NAD+ restoration delayed muscle deterioration and increased mouse life span. [39]
  3. In mice with muscular dystrophy, replenishing NAD+ stores with dietary nicotinamide riboside supplementation significantly improved muscle and heart function. [40]
  4. A study found that increased NNMT was commonly associated with muscle wasting disorders, suggesting that NNMT inhibitors like 5-amino-1MQ may provide benefits. [41]

5 Amino 1MQ Peptide Therapy

5-amino-1MQ peptide therapy is a promising and innovative approach in the field of health and wellness. This therapy utilizes a specific peptide, 5-amino-1MQ, to target and modulate various metabolic processes in the body, particularly those related to weight management, muscle health, and overall well-being.

What sets 5-amino-1MQ peptide therapy apart is its ability to selectively impact key enzymes within metabolic cycles without interfering with other enzymes, minimizing the risk of adverse effects. This targeted approach has garnered attention for its potential to reverse obesity, improve athletic performance, and improve overall health. As research in this area continues to expand, 5-amino-1MQ peptide therapy holds promise as a valuable tool in the pursuit of better health and fitness outcomes.

5 Amino 1MQ Side Effects

5-amino-1MQ side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on 5-amino-1MQ. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of 5-amino-1MQ. Despite this, it was listed as a side effect associated with 5-amino-1MQ even though these associated side effects are very uncommon.

Side effects associated with 5-amino-1MQ may include the following:

  • Difficulty sleeping
  • Difficulty participating in exercise

5 Amino 1MQ Dosage

The dosage of 5 Amino 1MQ peptide can vary depending on several factors, including the specific medical condition it’s being used to treat, individual patient factors, and the form in which it is administered (e.g. 5 amino 1mq capsules). It is crucial to follow the prescribed dosage and administration instructions provided by a qualified healthcare professional, such as a doctor or pharmacist. Self-administering or altering the dosage without medical guidance can be dangerous and is not recommended. If you have been prescribed 5-amino-1MQ, please consult your healthcare provider for precise dosing instructions tailored to your unique needs.

5 Amino 1MQ Before and After

About Dr. George Shanlikian

Dr. George Shanlikian, renowned as the world’s best hormone therapy doctor, possesses expertise in various medical domains. These include Bio-Identical Hormone Replacement Therapy, Peptide Replacement Therapy, Anti-Aging Medicine, Regenerative Medicine, Stress Management, Nutrition Consulting, Nutritional Supplement Consulting, and Exercise Consulting.

Read more about him here: https://www.genemedics.com/dr-george-shanlikian-md-best-hormone-therapy-doctor

Read more success stories here:

Men’s Success Stories: https://www.genemedics.com/about-ghi/ghi-success-stories/mens-success-stories/

Women’s Success Stories: https://www.genemedics.com/about-ghi/ghi-success-stories/womens-success-stories/

5 Amino 1MQ Results

The timing for seeing results from 5-amino-1MQ can vary depending on factors such as the individual’s metabolism, dosage, and specific health goals.

Share This Page

FAQ

How much weight will you lose with 5-amino-1MQ?

The amount of weight you will use when using 5-amino-1MQ will depend on various factors such as your exercise regime and eating habits. To achieve the best weight loss outcomes, you must still eat fewer calories than you burn.

Does 5-amino-1MQ affect muscle mass?

5-amino-1MQ may help burn fat and preserve muscle mass for some individuals, but individual responses can vary.

Is 5-amino-1MQ suitable for athletes or bodybuilders?

5-amino-1MQ has the potential to increase muscle mass, resulting in increased athletic power and ability. However, athletes and bodybuilders should consult with a healthcare professional first.

Are there any contraindications for using 5-amino-1MQ?

Yes, there are some contraindications for using 5-amino-1MQ such as pregnancy, breastfeeding, kidney disease, and liver disease.

Can 5-amino-1MQ be taken alongside other supplements or medications?

It’s advisable to consult with a healthcare provider before taking 5-amino-1MQ alongside other supplements or medications to ensure safety and avoid potential interactions.

Does 5-amino-1MQ have any effects on metabolism?

Yes, 5-amino-1MQ may have effects on metabolism, potentially related to its impact on adipose tissue and energy expenditure.

Can 5-amino-1MQ be used as part of a fitness regimen?

Yes, 5-amino-1MQ can potentially be included as part of a fitness regimen to support weight management and muscle health. However, it is important to keep in mind that you should consume fewer calories than you burn to achieve effective and sustainable weight loss.

Are there any specific dietary recommendations while using 5-amino-1MQ?

While using 5-amino-1MQ, it’s recommended to maintain a balanced diet rich in nutrients and stay adequately hydrated to support overall health and optimize its potential benefits.

Reference

  1. Available from https://apps.dtic.mil/dtic/tr/fulltext/u2/1059191.pdf.

  2. Available from https://diabetes.diabetesjournals.org/content/67/Supplement_1/115-LB.

  3. Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. BiochemPharmacol. 2018;147:141–152. doi:10.1016/j.bcp.2017.11.007

  4. Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014; 508:258–262.

  5. Kannt A, et al. Association of nicotinamide-N-methyltransferase mRNA expression in humanadipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulinresistance. Diabetologia. 2015; doi: 10.1007/s00125-014-3490-7.

  6. Liu M, et al. Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.J ClinEndocrinolMetab. 2015; 100:3112–3117.

  7. Pissios P. Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. Trends EndocrinolMetab. 2017;28(5):340–353.

  8. Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60(12):5015–5028.

  9. Kim, Y. B., Peroni, O. D., Aschenbach, W. G., Minokoshi, Y., Kotani, K., Zisman, A., Kahn, C. R., Goodyear, L. J., & Kahn, B. B. (2005). Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Molecular and cellular biology, 25(21), 9713–9723. https://doi.org/10.1128/MCB.25.21.9713-9723.2005.

  10. Carvalho, E., Kotani, K., Peroni, O. D., & Kahn, B. B. (2005). Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. American journal of physiology. Endocrinology and metabolism, 289(4), E551–E561. https://doi.org/10.1152/ajpendo.00116.2005.

  11. X. Ye, M. Li, T. Hou, T. Gao, W.-g. Zhu, Y. Yang. Sirtuins in glucose and lipid metabolism. Oncotarget, 8 (1) (2016), pp. 1845-1859.

  12. H. Yaguchi, K. Togawa, M. Moritani, and M. Itakura, “Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL,” Genomics, vol. 85, no. 5, pp. 591–599, 2005.

  13. A. Kannt, A. Pfenninger, L. Teichert et al., “Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance,” Diabetologia, vol. 58, no. 4, pp. 799–808, 2015.

  14. D. Kraus, Q. Yang, D. Kong et al., “Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity,” Nature, vol. 508, no. 7495, pp. 258–262, 2014.

  15. S. Hong, J. M. Moreno-Navarrete, X. Wei et al., “Nicotinamide N -methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization,” Nature medicine, vol. 21, no. 8, pp. 887–894, 2015.

  16. J. H. Li, Y. H. Wang, X. J. Zhu, Q. Zhou, Z. H. Xie, and T. F. Yao, “Metabolomics study on the association between nicotinamide N-methyltransferase gene polymorphisms and type 2 diabetes,” International Journal of Diabetes in Developing Countries, vol. 38, pp. 409–416, 2018.

  17. Moraes-Vieira, P. M., Saghatelian, A., & Kahn, B. B. (2016). GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes, 65(7), 1808–1815. https://doi.org/10.2337/db16-0221.

  18. Kim HC, et al. Expression and functional significance of nicotinamide N-methyl transferase inskeletal muscles of patients with chronic obstructive pulmonary disease. Am J RespirCrit CareMed. 2010; 181:797–805.

  19. Savarimuthu Francis SM, et al. Genes and gene ontologies common to airflow obstruction andemphysema in the lungs of patients with COPD. PloS One. 2011; 6:e17442.

  20. Sternak M, et al. Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse. Pharmacol Rep PR. 2010;62:483–493.

  21. Fedorowicz A, et al. Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension. Respir Res. 2016; 17:108.

  22. Jakubowski A, et al. 1-Methylnicotinamide protects against liver injury induced by concanavalin Avia a prostacyclin-dependent mechanism: A possible involvement of IL-4 and TNF-α. IntImmunopharmacol. 2016; 31:98–104.

  23. Markert JM, et al. Differential gene expression profiling in human brain tumors. Physiol Genomics. 2001;5:21–33.

  24. Xu J, et al. Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J ClinEndocrinolMetab. 2003;88:4990–4996.

  25. Yao M, et al. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol. 2005;205:377–387.

  26. Wu Y, et al. Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene. 2008;27:6679–6689.

  27. Jang JS, et al. The differential proteome profile of stomach cancer: identification of the biomarker candidates. Oncol Res. 2004;14:491–499.

  28. Lim BH, et al. Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification. ExpMol Med. 2006;38:455–465.

  29. Roessler M, et al. Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin Cancer Res Off J Am Assoc Cancer Res. 2005;11:6550–6557.

  30. Sartini D, et al. Nicotinamide N-methyltransferaseupregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol Med Camb Mass. 2007;13:415–421.

  31. Wu Y, et al. Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene. 2008;27:6679–6689.

  32. Yu T, et al. Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress. Cell PhysiolBiochemInt J Exp Cell PhysiolBiochemPharmacol. 2015;35:710–721.

  33. Tang SW, et al. Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. Carcinogenesis. 2011;32:138–145.

  34. Pozzi V, et al. RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells. PloS One. 2013;8:e71272.

  35. Bach DH, Kim D, Bae SY, et al. Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells. MolTher Nucleic Acids. 2018;11:455–467. doi:10.1016/j.omtn.2018.03.011.

  36. Bae S.Y., Park H.J., Hong J.Y., Lee H.J., Lee S.K. Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions. Sci. Rep. 2016;6:32258.

  37. Gao Y, Van haren MJ, Moret EE, et al. Bisubstrate Inhibitors of Nicotinamide -Methyltransferase (NNMT) with Enhanced Activity. J Med Chem. 2019;62(14):6597-6614.

  38. Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. BiochemPharmacol. 2019;163:481-492.

  39. Zhang H, et al. NAD+ repletion improves mitochondrial and stem cell function and enhances lifespan in mice. Science. 2016; 352:1436–1443.

  40. Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., Bellemin, S., Iyer, S. R., Wang, X., Gariani, K., Sauve, A. A., Cantó, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., … Auwerx, J. (2016). NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine, 8(361), 361ra139. https://doi.org/10.1126/scitranslmed.aaf5504.

  41. Pissios P. (2017). Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. Trends in endocrinology and metabolism: TEM, 28(5), 340–353. https://doi.org/10.1016/j.tem.2017.02.004.

Other Peptides

Mitochondrial ORF of the twelve S c (MOTS-c)

Ipamorelin

Melanotan 1

Valproic Acid

Bremelanotide

Success Stories

men testimonial before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...
Nick Cassavetes ,60 yrs old Movie Director (“The Notebook”, “John Q”, “Alpha Dog”), Actor and Writer

See All Men’s Testimonials

Call 800-277-4041 for a Free Consultation

What to expect during your consultation:
  • Usually takes 15-30 minutes
  • Completely confidential
  • No obligation to purchase anything
  • We will discuss your symptoms along with your health and fitness goals
  • Free post-consult access for any additional questions you may have

About

Genemedics® Health Institute is a global premier institute dedicated to revolutionizing health and medicine through healthy lifestyle education, guidance and accountability in harmony with functional medicine. Our physician-supervised health programs are personally customized to help you reach your health and fitness goals while looking and feeling better than ever.

Quick Links

Our Services

 Our Locations

genemedics logo

280 North Old Woodward Ave. Suite 210 Birmingham MI 48009,USA

800-277-4041

info@genemedics.com

© Copyright Genemedics Health Institute. All Rights Reserved. Privacy Policy.

Back to Top
-

Free Consultation

STEPS AWAY FROM A YOUNGER. HEALTHIER YOU!

Call 800-277-4041 for a Free Consultation

What to expect during your consultation:

  • Usually takes 15-30 minutes
  • Completely confidential
  • No obligation to purchase anything
  • We will discuss your symptoms along with your health and fitness goals
  • Free post-consult access for any additional questions you may have
Captch Background