Graviola Leaf Powder

Overall Health Benefits of Graviola Leaf Powder (Annona muricata)

• Improves symptoms of diabetes [1-9]
• Lowers blood pressure [10-13]
• Boosts sexual vitality and improves sexual health [14-15]
• Speeds up wound healing and regeneration [16-19]
• Protects against liver and kidney disease [20]
• Combats cancer [21-38]

How Graviola Leaf Powder (Annona muricata) Works

Graviola is a potent antioxidant, which means that it can help protect the body against harmful free radicals. It contains several compounds with antioxidant abilities such as tannins, saponins, flavonoids, anthraquinones, and phytosterols.

Proven Health Benefits of Graviola Leaf Powder (Annona muricata)

Improves Symptoms of Diabetes

Several lines of clinical evidence suggest that graviola has beneficial effects on people diagnosed with diabetes mellitus and those with chronic elevations in blood sugar levels:

1. A study found that the hypoglycemic and antioxidative properties of graviola improved blood sugar levels in diabetic animals. [1]
2. A study showed that graviola can be beneficial in the treatment and management of hyperglycemia (high blood sugar levels) and other symptoms of diabetes. [2]
3. A study found that graviola improved symptoms in diabetic patients with minimal to no adverse side effects. [3]
4. A study reported that graviola leaf extracts can help reduce blood sugar levels without any untoward signs and symptoms. [4]
5. A review of several studies found that graviola leaf extract can safely and effectively reduce blood sugar levels in diabetics. [5]
6. In streptozotocin-induced diabetic rats, graviola leaf extract supplementation at a dose of 100mg/kg significantly reduced blood sugar levels. [6]
7. In an animal experiment, researchers found that graviola leaves contain flavonoids and phenolic compound alkaloids that are necessary for the increased production of pancreatic beta cells (secrete insulin to reduce blood sugar levels). [7-8]
8. In Wistar rats, graviola leaf extract decreased blood sugar levels by inhibiting carbohydrate-hydrolyzing enzymes such as α-amylase and α-glucosidase. [9]

Lowers Blood Pressure

Studies also show that supplementation with graviola leaf can help achieve a healthy blood pressure:

1. In Sprague-Dawley rats, graviola leaf exerted hypotensive effects (blood pressure-lowering effects). [10]
2. In rats, pretreatment with graviola leaf extract at 250 mg/kg normalized blood pressure by reducing the markers of oxidative stress and improving the antioxidant defense system [11]
3. A study found that graviola can lower blood pressure by decreasing uric acid levels. [12]
4. A study found that graviola reduced blood pressure and other metabolic parameters in patients with diabetes mellitus. [13]

Boosts Sexual Vitality and Improves Sexual Health

Evidence suggests that graviola leaf has beneficial effects on libido:

1. In diabetic animals, researchers found that both the hypoglycemic and antioxidative potential of graviola are possible mechanisms responsible for the reduction of genes and substances that stimulate death of testicular cells and testicular inflammation. [14]
2. In albino rats, graviola mitigated the caffeine-induced toxicity on weight of testes and epididymes, sperm motility, and sperm count. [15]

Speeds Up Wound Healing and Regeneration

Numerous studies suggest that graviola has strong regenerative properties necessary for wound healing and tissue regeneration:

1. In guinea pigs with heart injury associated with low oxygen supply, graviola leaf improved the contractility of the myocardium (heart muscle). [16]
2. A study found that graviola leaf exhibited antiulcer potential via suppression of oxidative damage and preservation of the gastric wall mucus. [17]
3. A study also found that graviola leaf extract can speed up the wound healing process via inhibition of the production of inflammatory substances. [18]
4. A study showed that graviola leaf extract has an analgesic effect. [19]

Protects against Liver and Kidney Disease

Evidence also suggests that graviola can help protect against liver and kidney disease:

1. A study found that low doses of graviola leaf extract protected the liver and kidneys of mice against bacterial infections by suppressing inflammation. [20]

Combats Cancer

There’s a great deal of evidence supporting the potent anti-cancer properties of graviola leaf:

1. A study reported that the acetogenins from the leaf extracts of graviola have the ability to induce death of tumor cells. [21]
2. A study showed that graviola leaf extract can promote selective cancer cell death via inhibition of NKA and SERCA. [22]
3. In human pancreatic cancer cells, graviola exhibited anti-cancer properties by inhibiting cellular metabolism. [23]
4. A study reported that graviola leaf extract is effective at killing various types of cancer. [24]
5. In skin cancer cells, graviola showed significant cytotoxic activity against malignant cells and higher percentage of cell growth inhibition. [25]
6. A study showed that the anti-inflammatory activities of graviola can help inhibit the progression of cancer. [26]
7. In mouse breast cancer cells, graviola reduced tumor size and weight via induction of programmed cell death (apoptosis). [27-28]
8. In colon cancer cells, graviola induced cell cycle arrest and apoptosis. [29]
9. In human leukemia cell line, graviola inhibited cancer cell growth. [30]
10. In prostate cancer cell lines, graviola inhibited tumor mobility and cellular metabolism. [31-33]
11. In Lewis lung carcinoma (LLC) tumor cell lines, graviola inhibited the normal growth of the lung tumors by depleting their energy source and by inducing cell cycle arrest. [34-37]
12. In female albino mice, graviola leaf extract prevented the development of breast cancer. [38]

References:

1. Alsenosy AA, El-Far AH, Sadek KM, et al. Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats. PLoS One. 2019;14(9):e0222410. Published 2019 Sep 11. doi:10.1371/journal.pone.0222410.
2. Agu, K.C., Eluehike, N., Ofeimun, R.O. et al. Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities. Clin Phytosci 5, 21 (2019).
3. Agu, K.C., Eluehike, N., Ofeimun, R.O. et al. Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities. Clin Phytosci 5, 21 (2019).
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7. Damayanti DS, Utomo DH, Kusuma C. Revealing the potency of Annona muricata leaves extract as FOXO1 inhibitor for diabetes mellitus treatment through computational study. In Silico Pharmacol. 2016;5(1):3. doi:10.1007/s40203-017-0023-3.
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9. Available from https://link.springer.com/article/10.1186/s40816-019-0116-0.
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11. Ola-Davies, O., Oyagbemi, A., Omobowale, T., Akande, I., & Ashafa, A. (2019). Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling, Journal of Basic and Clinical Physiology and Pharmacology, 30(4), 20180172.
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15. B. Ekaluo, E.V. Ikpeme, Y.B. Ibiang and F.O. Omordia, 2013. Effect of Soursop (Annona muricata L.) Fruit Extract on Sperm Toxicity Induced by Caffeine in Albino Rats. Journal of Medical Sciences, 13: 67-71.
16. Robbert Bipat, Jerry R. Toelsie, Indira Magali, Rubaina Soekhoe, Karin Stender, Angelique Wangsawirana, Krishan Oedairadjsingh, Jennifer Pawirodihardjo & Dennis R. A. Mans (2016) Beneficial effect of medicinal plants on the contractility of post-hypoxic isolated guinea pig atria – Potential implications for the treatment of ischemic–reperfusion injury, Pharmaceutical Biology, 54:8, 1483-1489, DOI: 10.3109/13880209.2015.1107103.
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20. Borjac, Jamilah. (2017). Histopathological Effects of the Annona muricata Aqueous Leaves Extract on the Liver and Kidneys of Albino Mice. Translational medicine. 7. 194. 10.4172/2161-1025.1000194.
21. Qazi AK, Siddiqui JA, Jahan R, et al. Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis. 2018;39(4):522-533. doi:10.1093/carcin/bgy024
22. Yiallouris, A., Patrikios, I., Johnson, E. et al. Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways. Cell Death Dis 9, 764 (2018).
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29. Soheil Zorofchian Moghadamtousi, Hamed Karimian, Elham Rouhollahi, Mohammadjavad Paydar, Mehran Fadaeinasab, Habsah Abdul Kadir. Annona muricataleavesinduceG1 cell cyclearrest and apoptosis through mitochondria-mediated pathwayinhumanHCT-116 and HT-29 colon cancercells Journal of Ethnopharmacology 156 (2014) 277-289.
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