Caffeine Anhydrous

Overall Health Benefits of Caffeine Anhydrous

• Lowers blood sugar levels [1-2]
• Boosts sexual vitality and improves sexual health [3-5]
• Lowers the risk of stroke [6-9]
• Improves kidney function [10-11]
• Increases muscle mass and strength [12-13]
• Prevents Alzheimer’s disease (AD) and boosts cognitive health [14-15]
• Prevents cancer [16]
• Improves exercise performance [17-19]

What is Caffeine Anhydrous?

Caffeine anhydrous is dehydrated caffeine in a form of highly concentrated crystallized powder. It is naturally made from coffee, tea, and other plants that contain caffeine. It can also be manufactured from the chemicals of urea and chloroacetic acid. This nervous system stimulant can be taken in the form of pills, gums, or gels.

How Caffeine Anhydrous Works

Dehydrated caffeine works the same way as caffeine from a natural source. When consumed, caffeine prevents too much adenosine which helps you feel awake for longer periods of time. It is also a proven performance enhancer that can help benefit exercise performance and other daily activities.

Chemical Structure of Caffeine Anhydrous

Research on Caffeine Anhydrous

A. Lowers Blood Sugar Levels

Consuming caffeine anhydrous can help lower blood sugar levels, making it beneficial for people with diabetes:

1. In healthy humans, caffeine anhydrous decreased blood sugar levels by affecting the levels of the hormone insulin. [1]
2. A study found that long-term caffeine anhydrous intake can help lower the risk of diabetes. [2]

B. Boosts Sexual Vitality and Improves Sexual Health

Caffeine anhydrous intake has also been found to benefit people with sexual dysfunction:

1. In men, caffeine anhydrous intake at 170-375 mg/day was associated with a lower risk of erectile dysfunction. [3]
2. Studies also show that caffeine is safe and does not increase the risk of infertility. [4-5]

C. Lowers the Risk of Stroke

Studies show that caffeine anhydrousconsumption has beneficial effects on stroke risk:

1. A study showed that caffeine anhydrousconsumption of 4 cups or more per day showed a preventive effect on stroke. [6]
2. Studies also found a strong link between higher caffeine anhydrous intake and a lower risk of stroke. [7-9]

D. Improves Kidney Function

Evidence suggests that caffeine anhydrous can also help improve kidney function:

1. In people with the highest caffeine intake, a lower risk of developing kidney stones was found. [10]
2. In patients that consumed higher levels of caffeine, a nearly 25% reduction in the risk of death related to kidney disease was found. [11]

E. Increases Muscle Mass and Strength

Studies show that caffeine anhydrous has positive effects on muscle health:

1. In resistance-trained men, caffeine intake enhanced muscular strength and power, muscular endurance, and rate of perceived exertion (RPE). [12]
2. A study showed that caffeine may block signals that cause the skeletal muscle to break down. [13]

F. Prevents Alzheimer’s Disease (AD) and Boosts Cognitive Health

Caffeine anhydrous has also been shown to boost cognitive function:

1. A study showed that drinking coffee 3-5 cups per day at midlife was linked with a decreased risk of dementia/AD by about 65% at late-life. [14]
2. In healthy volunteers, caffeine intake improved neurocognitive functions and driving performance. [15]

G. Prevents Cancer

A study showed that the addition of caffeine anhydrous to antitumor drugs may help increase the efficacy of the treatment. [16]

H. Improves Exercise Performance

A convincing number of studies suggest that caffeine anhydrous can help boost exercise performance in both athletes and physically active individuals:

1. A study showed that caffeine anhydrous improved strength outcomes and sprinting performance in runners. [17]
2. In soccer players, caffeine anhydrous consumption before practice enhanced physical performance. [18]
3. In resistance-trained subjects, Supplementation with caffeine anhydrous improved training performance without adversely affecting blood chemistry. [19]

Associated Side Effects of Caffeine Anhydrous

Caffeine anhydrous side effects are very uncommon. There have been some side effects associated with its use wherein the patient had one of the issues listed below at some point while being on caffeine anhydrous. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of caffeine anhydrous. Despite this, it was listed as a side effect associated with caffeine anhydrous even though these associated side effects are very uncommon.

Side effects associated with caffeine anhydrous may include the following:

• Anxiety
• Diarrhea
• Headaches
• Nausea
• Restlessness
• Trouble sleeping

References

1. Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25(2):364-9. doi: 10.2337/diacare.25.2.364. PMID: 11815511.
2. Pimentel GD, Zemdegs JC, Theodoro JA, Mota JF. Does long-term coffee intake reduce type 2 diabetes mellitus risk?.DiabetolMetabSyndr. 2009;1(1):6. Published 2009 Sep 16. doi:10.1186/1758-5996-1-6.
3. Lopez DS, Wang R, Tsilidis KK, et al. Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004. PLoS One. 2015;10(4):e0123547. Published 2015 Apr 28. doi:10.1371/journal.pone.0123547.
4. Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry. 2017;8:80. Published 2017 May 26. doi:10.3389/fpsyt.2017.00080.
5. Available from https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-020-00973-z.
6. Ojeh N, Stojadinovic O, Pastar I, Sawaya A, Yin N, Tomic-Canic M. The effects of caffeine on wound healing. Int Wound J. 2016 Oct;13(5):605-13. doi: 10.1111/iwj.12327. Epub 2014 Jul 8. PMID: 25041108.
7. Freedman et al., 2012. N.D. Freedman, Y. Park, C.C. Abnet, A.R. Hollenbeck, R. Sinha.Association of coffee drinking with total and cause-specific mortality. N. Engl. J. Med., 366 (2012), pp. 1891-1904.
8. Kokubo et al., 2013. Y. Kokubo, H. Iso, I. Saito, K. Yamagishi, H. Yatsuya, J. Ishihara, M. Inoue, S. Tsugane. The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohortStroke, 44 (5) (2013), pp. 1369-1374.
9. Kuriyama et al., 2006. S. Kuriyama, T. Shimazu, K. Ohmori, N. Kikuchi, N. Nakaya, Y. Nishino, Y. Tsubono, I. Tsuji. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA, 296 (10) (2006), pp. 1255-1265.
10. Available from https://www.kjfm.or.kr/journal/view.php?doi=10.4082/kjfm.2012.33.6.356.
11. Ferraro PM, Taylor EN, Gambaro G, Curhan GC. Caffeine intake and the risk of kidney stones. Am J ClinNutr. 2014;100(6):1596-1603. doi:10.3945/ajcn.114.089987.
12. Grgic&PavleMikulic (2017) Caffeine ingestion acutely enhances muscular strength and power but not muscular endurance in resistance-trained men, European Journal of Sport Science, 17:8, 1029-1036, DOI: 10.1080/17461391.2017.1330362.
13. Moore TM, Mortensen XM, Ashby CK, Harris AM, Kump KJ, Laird DW, Adams AJ, Bray JK, Chen T, Thomson DM. The effect of caffeine on skeletal muscle anabolic signaling and hypertrophy. ApplPhysiolNutrMetab. 2017 Jun;42(6):621-629. doi: 10.1139/apnm-2016-0547. Epub 2017 Jan 26. PMID: 28177708.
14. Eskelinen, Marjo H., and MiiaKivipelto. “Caffeine as a Protective Factor in Dementia and Alzheimer’s Disease.” Journal of Alzheimer’s Disease : JAD, vol. 20 Suppl 1, 2010, pp. S167-74.
15. Available from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202247.
16. Abe, K., Yamamoto, N., Hayashi, K. et al. Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo. BMC Cancer 19, 689 (2019). https://doi.org/10.1186/s12885-019-5891-y.
17. Trexler ET, Smith-Ryan AE, Roelofs EJ, Hirsch KR, Mock MG. Effects of coffee and caffeine anhydrous on strength and sprint performance. Eur J Sport Sci. 2016 Sep;16(6):702-10. doi: 10.1080/17461391.2015.1085097. Epub 2015 Sep 22. PMID: 26394649; PMCID: PMC4803635.
18. Mielgo-Ayuso J, Calleja-Gonzalez J, Del Coso J, Urdampilleta A, León-Guereño P, Fernández-Lázaro D. Caffeine Supplementation and Physical Performance, Muscle Damage and Perception of Fatigue in Soccer Players: A Systematic Review. Nutrients. 2019;11(2):440. Published 2019 Feb 20. doi:10.3390/nu11020440.
19. Joy JM, Vogel RM, Moon JR, Falcone PH, Mosman MM, Kim MP. Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men. J IntSoc Sports Nutr. 2016;13:25. Published 2016 Jun 10. doi:10.1186/s12970-016-0136-9.