Bacopa monnieri

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Overall Health Benefits of Bacopa
Key Takeaways
What is Bacopa?
Chemical Structure of Bacopa
Research on Bacopa
Bacopa Monnieri Side Effects
What is Bacopa For?
Bacopa Extract in Attention Deficit Hyperactivity Disorder (ADHD)
Bacopa Monnieri Benefits for Hair
Bacopa Monnieri Nootropic
Bacopa Mechanism of Action
Bacopa Schizophrenia
FAQ
Reference

Overall Health Benefits of Bacopa

Bacopa benefits include its potential to enhance cognitive function, reduce anxiety and stress, provide neuroprotective effects, and reduce inflammation due to its adaptogenic and antioxidant properties.

Improves cognitive function [1-18]
Fights anxiety and stress [19-24]
Wards off depression [25-33]
Lowers blood pressure [34-36]
Fights various types of cancers [37-52]

Key Takeaways

Cognitive Enhancement: Bacopa is known for improving memory, attention, and overall cognitive function, particularly in aging populations.
Anxiety and Stress Reduction: Bacopa has adaptogenic properties that help mitigate anxiety and stress.
Neuroprotective Effects: Bacopa may protect brain cells from damage and support brain health.
Anti-inflammatory Properties: Bacopa contains compounds that can reduce inflammation in the body.
Antioxidant Activity: Bacopa helps neutralize free radicals, thereby reducing oxidative stress.

What is Bacopa?

Bacopa, also known as Bacopa monnieri, is an herb traditionally used in Ayurvedic medicine. It is primarily known for its cognitive-enhancing properties, but it also provides a range of other health benefits due to its adaptogenic and antioxidant properties.

How Bacopa Works

Bacopa works by enhancing synaptic communication, modulating neurotransmitter levels, reducing beta-amyloid plaque formation, and inhibiting inflammatory pathways. These mechanisms help improve cognitive function, reduce anxiety and stress, and protect against neurodegenerative diseases.

Chemical Structure of Bacopa

Bacopa contains several active compounds, including bacosides, which are responsible for its cognitive and neuroprotective effects. These compounds help enhance neurotransmission and protect neurons from damage.

Research on Bacopa

A. Improves Cognitive Function

The ability of Bacopa monnieri to positively affect cognitive function can be attributed to its high Bacoside content. Bacoside is a chemical compound that boosts brain power and prevents cognitive deficits. There’s a great deal of evidence supporting the beneficial effects of Bacopa monnieri on brain health:

An Australian survey found that Bacopa monnieri is one of the most prescribed supplements for memory problems among 60-64-year-old consumers. [1]
In human subjects with dementia or significant cognitive impairment, supplementation with Bacopa extract at 300-450 mg per day improved memory free recall. [2]
In adults aged between 40 and 65 years, Bacopa monnieri supplementation for 3 months decreased the rate of forgetting of newly acquired information. [3]
In healthy elderly people, Bacopa monnieri supplementation significantly improved memory acquisition and retention. [4-5]
In patients with anxiety, supplementation with Bacopa monnieri extract at 300 mg/day improved memory and learning. [6]
In participants (65 or older) without clinical signs of dementia, treatment with Bacopa monnieri improved scores in a series of tests assessing attention, immediate working memory, and verbal learning. [7]
In healthy participants, treatment with a special extract of Bacopa monnieri (2 x 150 mg KeenMind) for 90 days improved spatial working memory accuracy. [8]
In healthy older Australians, Bacopa monnieri treatment significantly improved verbal learning, memory acquisition, and delayed recall. [9]
In subjects with age-associated memory impairment, administration of standardized Bacopa monnieri extract at 125 mg twice daily produced significant improvement in mental control and logical memory. [10]
In healthy human subjects, Bacopa monnieri treatment (300 mg) significantly improved the speed of visual information processing. [11]
A review of Bacopa monnieri benefits by Rejuvenation Research found that this medicinal herb may promote healing in people with cognitive disorders. [12]
In postnatal rats, Bacopa monnieri treatment significantly enhanced learning and retention of memory. [13-14]
In Male Wistar rats, oral supplementation with alcoholic extract of Bacopa monnieri for 2 weeks improved spatial memory in the Morris water maze test. [15]
In mice with scopolamine-induced cognitive impairment, supplementation with Bacopa monnieriextractreversed short-term and long-term amnesia. [16]
In mice with diazepam-induced amnesia, supplementation with Bacopa monnieri suppressed cognitive impairment. [17]
In an Alzheimer’s disease animal model, Bacopa monnieri treatment reduced the levels of brain beta-amyloid, which are the causative agent of the disease. [18]

B. Fights Stress and Anxiety

Bacopa monnieri has actually been shown to reduce the detrimental effects of stress and anxiety on the body by improving coping mechanisms and reducing the levels of the stress hormone cortisol. Numerous studies support the anti-stress and anti-anxiety effects of this adaptogen:

In normal healthy participants, consumption of Bacopa monnieri at doses of 320-640 mg improved response to stress by reducing cortisol levels. [19]
In healthy urban adults, Bacopa monnieri treatment was associated with lower state anxiety. [20]
In healthy elderly participants, Bacopa monnieri treatment improved scores in a test assessing anxiety. [21-22]
In rats, Bacopa monnieri treatment reduced symptoms of chronic stress. [23]
In rodents, Bacopa monnieri treatment produced anti-anxiety effects comparable to those of lorazepam (benzodiazepine), a drug used to treat anxiety. [24]

C. Wards off Depression

It’s probably not too surprising that Bacopa monnieri can also help ward off depression because it has beneficial effects on stress and anxiety. In fact, most studies assessing its anti-depressant effect showed positive outcomes:

In healthy elderly participants, consumption of Bacopa monnieri at doses of 300 mg per day improved depression scores. [25]
Bacopa monnieri may help prevent depression by suppressing neuroinflammation, which is associated with depressive symptoms and psychiatric diseases. [26]
In a rat model of depression, Bacopa monnieri treatment exerted an antidepressant effect comparable to that of imipramine, a tricyclic antidepressant. [27]
In mice, Bacopa monnieri supplementation at varying doses (50, 100, and 200 mg/kg) reduced the duration of immobility times in the forced swimming test, which is indicative of an antidepressant effect. [28-30]
In a rat model of neuropathic pain, Bacopa monnieri reduced depressive-like behaviors by significantly reducing pain levels. [31]
In rats that were subjected to undergo chronic unpredictable stress, Bacopa monnieri greatly suppressed depressive-like behaviors. [32]
Administration of Bacopa monnieri also reduced morphine-induced depression in rats. [33]

D. Lowers Blood Pressure

Several studies show that Bacopa monnieri also has hypotensive properties that can help lower one’s risk for various diseases:

In postmenopausal women, Bacopa monnieri supplementation reduced blood pressure. [34]
In anesthetized rats, Bacopa monnieri supplementation (20-60 mg/kg) reduced blood pressure partly via releasing nitric oxide from the endothelium. [35]
Bacopa monnieri supplementation in rats reduced both systolic and diastolic blood pressure by relaxing blood vessels. [36]

E. Fights Various Types of Cancers

Bacopa monnieri can help treat and prevent deadly diseases such as cancer. Evidence suggests that this powerful medicinal herb is effective against various cancer types:

A cell study found that Bacopa monnieri slowed Dalton’s lymphoma ascites tumor cells, a highly invasive T-cell lymphoma. [37-38]
In mice cancer cell lines, treatment with an alcoholic extract of Bacopa monnieri induced programmed cell death (apoptosis). [39]
In human breast cancer cell lines, treatment with an alcoholic extract of Bacopa monnieridisplayed anti-tumor activities. [40-42]
In human colon cancer cell lines, Bacopa monnieri induced cell cycle arrest and apoptosis. [43]
In human brain cancer cell lines, Bacopa monnieri induced tumor cell death. [44]
In rats, Bacopa monnieri exerted anti-cancer properties comparable to that of chemotherapeutic drugs. [45]
In rats with liver cancer cells, Bacopa monnieri induced death of cancer cells by enhancing antioxidant status through free radical scavenging mechanisms. [46]
In mice with breast cancer cells, water extract of Bacopa monnieri induced apoptosis. [47-48]
In a mouse model of skin cancer, Bacopa monnieri extract treatment induced cell cycle arrest. [49-50]
10. In mice with Ehrlich Ascites Carcinoma (liver cancer), Bacopa monnieri reduced the number of cancer cells. [51-52]

Bacopa Monnieri Side Effects

Bacopa monnieri, also known as Brahmi, is an herb commonly used in traditional Ayurvedic medicine for its potential cognitive benefits. While it is generally considered safe for most people when taken in recommended doses, some may experience side effects. Common side effects include gastrointestinal issues such as nausea, stomach cramps, bloating, and diarrhea. These symptoms are usually mild and tend to subside as the body adjusts to the supplement.

In some cases, Bacopa monnieri may cause fatigue or drowsiness. This is likely due to its calming effects on the nervous system, which can induce a state of relaxation. People taking the herb should be cautious if they plan to drive or operate heavy machinery. Additionally, Bacopa monnieri may interact with other medications, such as sedatives or antidepressants, potentially enhancing their effects.

Allergic reactions are rare but possible. Symptoms can include itching, rashes, or swelling, especially in individuals sensitive to herbal supplements. As with any supplement, it’s crucial to consult with a healthcare provider before starting Bacopa monnieri, especially for those who are pregnant, breastfeeding, or have underlying health conditions.

What is Bacopa For?

Bacopa Monnieri, commonly known as Bacopa, is an herb traditionally used in Ayurvedic medicine for its potential cognitive and neurological benefits. It has been used to enhance memory, learning, and concentration, making it a popular supplement for students and individuals seeking to improve their mental clarity. The herb contains active compounds called bacosides, which are believed to enhance synaptic communication and protect brain cells from oxidative stress.

In addition to its cognitive benefits, Bacopa is also used for its potential anxiolytic effects. It may help reduce anxiety and stress by modulating the levels of certain neurotransmitters in the brain, such as serotonin and dopamine. This calming effect can contribute to an overall sense of well-being and improve mood. As a result, Bacopa is sometimes recommended as a natural remedy for individuals experiencing mild anxiety or stress-related symptoms.

Beyond its effects on the brain, Bacopa has also been explored for its antioxidant and anti-inflammatory properties. These qualities make it a potential supplement for supporting overall health and combating oxidative damage in the body. Some research suggests that Bacopa may help protect against age-related cognitive decline and support heart health, although more studies are needed to fully understand its benefits and mechanisms of action.

Bacopa Extract in Attention Deficit Hyperactivity Disorder (ADHD)

Bacopa monnieri, commonly known as Brahmi, is a traditional herbal medicine used in Ayurveda for enhancing cognitive function. Recent studies suggest that Bacopa may have potential benefits for individuals with Attention Deficit Hyperactivity Disorder (ADHD). The herb is believed to work by modulating neurotransmitter levels in the brain, particularly acetylcholine, serotonin, and dopamine, which play crucial roles in attention, mood, and impulse control. These effects may help improve focus and reduce hyperactive and impulsive behaviors in those with ADHD.

Clinical trials examining Bacopa’s efficacy in ADHD treatment have shown promising results. Some studies report that children with ADHD who were given Bacopa supplements experienced improvements in attention, cognitive processing, and impulse control compared to those who received a placebo. Additionally, Bacopa is considered relatively safe, with fewer side effects compared to conventional stimulant medications commonly prescribed for ADHD. This makes it an appealing alternative or adjunctive treatment for some patients.

However, while the preliminary data is encouraging, further research is necessary to fully understand the extent of Bacopa’s benefits and its mechanisms of action. The current studies have limitations, such as small sample sizes and short durations, making it difficult to draw definitive conclusions. Therefore, it is essential for individuals considering Bacopa for ADHD to consult healthcare professionals to discuss its potential benefits and risks in the context of their unique medical profiles.

Bacopa Monnieri Benefits for Hair

Bacopa Monnieri, also known as Brahmi, is an herb traditionally used in Ayurvedic medicine for its numerous health benefits, including its potential to improve hair health. One of the primary benefits of Bacopa Monnieri for hair is its ability to promote hair growth. The herb contains alkaloids, saponins, and flavonoids that may help stimulate hair follicles and enhance hair density, leading to thicker and fuller hair. By improving scalp circulation, it can also provide essential nutrients to hair roots, promoting stronger and healthier hair.

Another significant benefit of Bacopa Monnieri is its antioxidant properties. The herb is rich in antioxidants, which can protect the scalp and hair from oxidative stress caused by free radicals. This protection helps in preventing premature graying and damage to hair shafts, maintaining the natural color and shine of the hair. Furthermore, its anti-inflammatory properties can soothe an irritated scalp, reducing issues like dandruff and scalp infections that may hinder hair growth.

Additionally, Bacopa Monnieri has been noted for its potential to reduce hair loss. Stress is a common factor contributing to hair loss, and Bacopa Monnieri is renowned for its adaptogenic properties, which help reduce stress and anxiety. By calming the mind and body, it can indirectly contribute to the reduction of stress-induced hair loss. Overall, incorporating Bacopa Monnieri into hair care routines, either through topical application or supplements, may offer a natural and holistic approach to maintaining healthy hair.

Bacopa Monnieri Nootropic

Bacopa Monnieri, commonly known as Brahmi, is a perennial herb traditionally used in Ayurvedic medicine for its cognitive-enhancing properties. This nootropic herb is renowned for its potential to improve memory, enhance cognitive function, and reduce anxiety. The active compounds in Bacopa Monnieri, called bacosides, are believed to support brain function by enhancing neuron communication and promoting the growth of nerve endings, thus facilitating better cognitive performance.

Scientific research on Bacopa Monnieri suggests that it may be beneficial for individuals experiencing age-related cognitive decline. Studies have shown that regular supplementation with this herb can improve attention, memory retention, and the speed of information processing. These effects are particularly notable in older adults, making Bacopa Monnieri a promising natural option for maintaining mental acuity with aging. Additionally, it has been observed to have adaptogenic properties, helping the body adapt to stress and reducing symptoms of anxiety and depression.

Despite its potential benefits, Bacopa Monnieri is not without possible side effects. Some users may experience gastrointestinal issues, such as nausea or cramping, particularly at higher doses. As with any supplement, it is crucial to consult with a healthcare professional before beginning a regimen, especially for individuals taking medications or with pre-existing health conditions. Overall, Bacopa Monnieri presents a natural and promising avenue for cognitive support, with a growing body of evidence backing its nootropic capabilities.

Bacopa Mechanism of Action

Bacopa monnieri, commonly known as Brahmi, is a traditional Ayurvedic herb with cognitive-enhancing properties. Its primary mechanism of action involves the modulation of neurotransmitter systems, particularly acetylcholine. Bacopa enhances cholinergic function by inhibiting the activity of the enzyme acetylcholinesterase, which breaks down acetylcholine in the synaptic cleft. This inhibition leads to increased levels of acetylcholine, a neurotransmitter associated with memory and learning processes, thereby potentially improving cognitive functions.

Additionally, Bacopa exhibits antioxidant properties, which play a crucial role in its neuroprotective effects. The herb contains active compounds like bacosides, which scavenge free radicals and reduce oxidative stress in the brain. This antioxidative action helps protect neuronal cells from damage and supports overall brain health. The reduction in oxidative stress is particularly significant as it may contribute to the prevention of neurodegenerative diseases and age-related cognitive decline.

Bacopa also influences the regulation of stress hormones, particularly by modulating the activity of the hypothalamic-pituitary-adrenal (HPA) axis. It helps reduce cortisol levels, a stress hormone, which in turn can alleviate stress and anxiety. The herb’s adaptogenic properties enable the body to better cope with stress, potentially improving mental clarity and emotional balance. Through these mechanisms, Bacopa monnieri supports cognitive function, mental health, and overall well-being.

Bacopa Schizophrenia

Bacopa monnieri, commonly known as Brahmi, is a traditional herbal remedy often used in Ayurvedic medicine for cognitive enhancement and stress relief. Recent studies have explored its potential benefits in treating schizophrenia, a chronic mental health disorder characterized by symptoms such as hallucinations, delusions, and cognitive impairments. The herb is believed to have neuroprotective properties, possibly due to its antioxidant and anti-inflammatory effects, which could help mitigate some of the cognitive deficits associated with schizophrenia.

Research on Bacopa monnieri’s effectiveness in schizophrenia treatment is still in its early stages, but some promising results have emerged. Preliminary studies suggest that Bacopa may help improve memory and cognitive function, which are often impaired in individuals with schizophrenia. Additionally, Bacopa’s potential anxiolytic effects could alleviate anxiety symptoms frequently co-occurring with schizophrenia, offering a more comprehensive approach to managing the disorder.

Despite these encouraging findings, more rigorous clinical trials are needed to establish Bacopa monnieri’s efficacy and safety in treating schizophrenia. Current research is limited by small sample sizes and methodological variability, making it difficult to draw definitive conclusions. Nonetheless, Bacopa remains a promising candidate for adjunctive therapy in schizophrenia, offering a natural alternative that could complement conventional treatments.

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FAQ

What does Bacopa do to the body?

Bacopa monnieri, often found in bacopa extract, is known for its adaptogenic and neuroprotective properties. Bacopa extract can enhance cognitive function, reduce anxiety, and improve memory by promoting neuronal communication and reducing oxidative stress. Additionally, bacopa extract may have anti-inflammatory and antioxidant effects, benefiting overall physical and mental health.

Who should not take bacopa?

Individuals who are pregnant or breastfeeding, have thyroid disorders, or are taking certain medications (such as sedatives, anticholinergic drugs, or thyroid hormones) should avoid bacopa monnieri standardized extract without consulting a healthcare provider. Bacopa monnieri standardized extract may also interact with medications for epilepsy and gastrointestinal issues, so caution is advised. When considering the use of bacopa monnieri standardized extract, it is crucial to consult with a healthcare provider to avoid potential interactions and side effects

Does bacopa increase dopamine?

Bacopa monnieri is thought to modulate neurotransmitter levels, including dopamine. While it may not directly increase dopamine, it can enhance cognitive function and mood by affecting various neurotransmitter systems, potentially improving the overall balance of these chemicals in the brain. Additionally, some studies suggest that Bacopa monnieri may have a positive effect on blood pressure, which can be beneficial for overall cardiovascular health. Maintaining healthy blood pressure levels is crucial for preventing a range of health issues, and Bacopa monnieri’s potential impact on neurotransmitters might also indirectly support blood pressure regulation.

Which is better Bacopa or Ashwagandha?

The choice between Bacopa, Gotu Kola, and Ashwagandha depends on individual needs and health goals. Bacopa is often preferred for its cognitive-enhancing and memory-boosting properties, while Gotu Kola and Ashwagandha are commonly used for stress reduction, anxiety relief, and their adaptogenic effects. Both Gotu Kola and Ashwagandha have unique benefits and can complement each other.

What is Bacopa monnieri good for?

Bacopa monnieri is primarily used for enhancing cognitive function, improving memory, reducing anxiety, and supporting overall brain health. It is also studied for its potential benefits in managing neurodegenerative disorders like Alzheimer disease, ADHD, and stress-related conditions. Additionally, Bacopa monnieri has shown promise in research for potentially benefiting those with Alzheimer disease. As a result, it has gained attention as a supplement for overall cognitive support and for possibly helping in the management of Alzheimer disease.

Who should not take Bacopa monnieri?

Similar to the broader category of Bacopa, individuals who are pregnant, breastfeeding, have thyroid issues, or are taking specific medications should avoid Bacopa monnieri without medical consultation. Bacopa monnieri is known to potentially lower blood pressure, so it is crucial for individuals with conditions related to blood pressure to consult a healthcare provider. It is essential to consult a healthcare provider before starting any new supplement, especially if you’re considering Bacopa monnieri, as it may lower blood pressure in some individuals. Always seek professional advice to ensure that taking Bacopa monnieri will not interfere with any existing health conditions, including those that lower blood pressure.

How does Bacopa make you feel?

Taking bacopa may help reduce stress and anxiety, leading to a sense of calm and relaxation. It can also improve cognitive function and clarity, potentially enhancing mood and overall mental well-being. Additionally, taking bacopa regularly could contribute to a better quality of life. Overall, taking bacopa might be a beneficial addition to your wellness routine.

How does Bacopa monnieri help ADHD?

Bacopa monnieri is believed to support ADHD treatment by enhancing cognitive function, improving attention and focus, and reducing hyperactivity. More research is needed to fully understand its effects. Its neuroprotective properties may help balance neurotransmitters, thereby aiding in managing ADHD symptoms. However, more research is necessary to confirm its efficacy and safety. While initial studies are promising, more research is required to establish Bacopa monnieri as a reliable treatment option for ADHD.

What does bacopa do to the brain?

Bacopa monnieri enhances brain function by promoting neuroplasticity, improving synaptic communication, and protecting neurons from oxidative stress. It may also influence neurotransmitter levels, potentially mitigating the risk of cholinergic toxicity and thereby supporting cognitive processes like memory, attention, and learning. Addressing cholinergic toxicity through such mechanisms can further bolster cognitive health and prevent potential damage.

Does bacopa raise blood pressure?

There is limited evidence to suggest that Bacopa significantly affects blood pressure. It may have mild vasodilatory effects, potentially lowering blood pressure by releasing nitric oxide. However, individuals with blood pressure concerns should consult a healthcare provider before using Bacopa, especially if they are interested in the effects of releasing nitric oxide. Further research is needed to fully understand how Bacopa influences blood pressure through mechanisms like releasing nitric oxide.

Does bacopa make you sleepy?

Bacopa, commonly called brahmi, is generally known for its calming effects, which may help reduce anxiety and improve sleep quality. However, it is not typically associated with causing drowsiness or significant sedation. Bacopa, commonly called brahmi, is often used in traditional medicine for its potential benefits. Bacopa, commonly called brahmi, can be a helpful supplement for those looking to manage stress and enhance their overall well-being.

Who shouldn't take bacopa?

People who are pregnant, breastfeeding, have thyroid disorders, or are on specific medications like chemotherapy drugs, sedatives, anticholinergics, or thyroid hormones should avoid Bacopa without medical advice. Those with gastrointestinal issues or taking epilepsy medications or chemotherapy drugs should also exercise caution.

Can you take bacopa everyday?

Yes, bacopa monniera extract can generally be taken daily as a supplement. However, it is crucial to follow the recommended dosage of bacopa monniera extract and consult a healthcare provider, especially if you have any pre-existing conditions or are taking other medications. Many people find bacopa monniera extract beneficial, but individual needs and responses may vary.

What effects does bacopa have on sleep?

Bacopa, like other herbs, may improve sleep quality by reducing anxiety and promoting relaxation. Its calming effects, similar to those of other herbs, can help alleviate stress, potentially making it easier to fall asleep and stay asleep. Many people turn to Bacopa and other herbs for natural sleep support.

What does Bacopa monnieri do for the body?

Bacopa monnieri benefits the body by enhancing cognitive function, reducing anxiety, and supporting overall brain health. Its antioxidant and anti-inflammatory properties may also contribute to general well-being and help protect against various stressors. Additionally, Bacopa monnieri may offer sleep benefits by promoting relaxation and reducing stress. For those seeking sleep benefits, incorporating Bacopa monnieri into a routine could support better rest. Overall, Bacopa monnieri’s diverse effects, including sleep benefits, make it a valuable addition to wellness practices.

What are the disadvantages of Bacopa monnieri?

Potential disadvantages of a calming cognitive enhancer include gastrointestinal issues, such as nausea or diarrhea, and possible interactions with other medications. Some people may also experience an increase in thyroid hormone levels or sedation from using a calming cognitive enhancer. As with any calming cognitive enhancer supplement, individual reactions can vary.

Does Bacopa monnieri make you sleepy?

While Bacopa monnieri, a well-known medicinal plant extract, can have calming effects, it is not typically associated with causing significant drowsiness. However, individual responses to medicinal plant extracts may vary, and some people may experience mild sedation. Overall, medicinal plant extracts like Bacopa monnieri are used for their therapeutic properties.

What is the homeopathic medicine Bacopa monnieri used for?

In homeopathy, Bacopa monnieri is used to support cognitive function, improve memory, reduce anxiety, and alleviate stress. It may also be used to address symptoms associated with thyroid hormone concentrations and mental fatigue. Additionally, Bacopa monnieri has been considered in the context of thyroid hormone concentrations and various neurodegenerative conditions. Some practitioners suggest that balancing thyroid hormone concentrations may enhance the overall effectiveness of Bacopa monnieri in supporting brain health.

What is Bacopa used for?

Bacopa is primarily used for its cognitive-enhancing properties, including improving memory, focus, and learning. Human research has shown that it is also used to reduce anxiety, support brain health, and potentially alleviate symptoms of neurological disorders. Additionally, human research continues to explore its benefits in these areas. The ongoing human research aims to provide more definitive conclusions about its efficacy.

What are the disadvantages of Bacopa?

Disadvantages may include gastrointestinal discomfort, potential interactions with medications, and the risk of side effects like nausea or increased thyroid hormone levels. It is essential to consult with a healthcare provider before starting Bacopa, especially if you have underlying health conditions.

Who shouldn't take Bacopa?

Individuals who are pregnant, breastfeeding, have thyroid disorders, have high blood pressure, or are taking specific medications (such as sedatives or anticholinergic drugs) should avoid Bacopa without consulting a healthcare provider. Additionally, those with high blood pressure should exercise caution and seek medical advice before using Bacopa, as it may interact with medications or exacerbate symptoms. It is crucial for anyone with high blood pressure to consult a healthcare professional to ensure safe and appropriate use.

What is bacopa good for?

Bacopa is known for improving cognitive function, enhancing memory, reducing anxiety, and supporting overall brain health. Unlike some anticholinergic medications, which may have side effects, Bacopa is considered a natural supplement with neuroprotective and adaptogenic properties. This makes it beneficial for managing stress and neurological conditions. Additionally, Bacopa may counteract the cognitive impairments sometimes associated with anticholinergic medications, offering a more holistic approach to brain health. For those seeking alternatives to anticholinergic medications, Bacopa presents a promising option for supporting cognitive function and overall well-being.

When should you take bacopa?

Bacopa can be taken at any time of the day, but it is often recommended to take it with meals to reduce the risk of gastrointestinal discomfort, leading to significant improvement in digestive comfort. Some people experience significant improvement in their cognitive function when taking it in the morning to support brain function throughout the day. Overall, the consistent use of Bacopa has shown a significant improvement in mental clarity and focus for many users.

Does bacopa raise your blood pressure?

There is no strong evidence to suggest that Bacopa significantly raises blood pressure. It may have mild vasodilatory effects on blood vessels, which could potentially lower blood pressure in some individuals. Bacopa’s impact on blood vessels might be minimal, but it could still influence blood pressure to some extent.

Does Bacopa monnieri help with ADHD?

Bacopa monnieri may help manage ADHD symptoms by improving attention, focus, and cognitive function. Animal studies suggest its potential neuroprotective effects and ability to modulate neurotransmitter levels. These animal studies make it a promising natural option for supporting ADHD treatment. Furthermore, additional animal studies support its efficacy in this regard.

What is the most powerful herb for ADHD?

While there is no single “most powerful” herb for ADHD, several herbs, including Bacopa monnieri, Ginkgo biloba, and Rhodiola rosea, are commonly used for their potential benefits in improving cognitive function and focus, which can influence behavioral outcomes. The effectiveness of these herbs can vary depending on the individual, impacting their overall behavioral outcomes. It’s important to consider how each herb might affect individual behavioral outcomes when determining the best approach for managing ADHD.

Does Bacopa help with focus?

Yes, Bacopa is known to improve focus and attention, and its cognitive-enhancing properties have been observed in several clinical trials. These trials support its ability to enhance mental clarity and concentration, making it a popular choice for those looking to boost their cognitive performance. Additionally, Bacopa’s potential effects on cancer cells have been a subject of interest, as some studies, including clinical trials, suggest it might influence cancer cells’ behavior. While Bacopa’s impact on cancer cells is still being researched through ongoing clinical trials, its overall cognitive benefits make it a valuable supplement for many.

Does Bacopa monnieri help hair growth?

While Bacopa monnieri is not primarily known for promoting hair growth, its antioxidant and anti-inflammatory properties may support overall scalp health, which could indirectly benefit hair growth. This support for scalp health could be particularly relevant for individuals with Parkinson disease, as maintaining a healthy scalp is important. Additionally, the benefits of Bacopa monnieri in managing stress and inflammation might have implications for those with Parkinson disease, potentially offering further indirect benefits for hair growth.

Does Bacopa affect hormones?

Research suggests Bacopa treatment may influence hormone levels, particularly thyroid hormones, by potentially increasing T4 levels, which could also impact individuals with mild cognitive impairment. Research suggests individuals with thyroid conditions and mild cognitive impairment should exercise caution and consult a healthcare provider before using Bacopa treatment. Additionally, consulting with a healthcare provider is essential for those with thyroid conditions or mild cognitive impairment before starting Bacopa treatment.

Is Bacopa monnieri a nootropic?

Yes, Bacopa monnieri, one of the three medicinal plant extracts, is considered a nootropic due to its potential to enhance cognitive function, improve memory, and support overall brain health. It is often used as a natural supplement for cognitive enhancement, alongside other three medicinal plant extracts. These three medicinal plant extracts contribute to various aspects of cognitive health, making Bacopa monnieri a popular choice for those looking to boost their mental performance.

How does Bacopa monnieri make you feel?

Bacopa monnieri may promote a sense of calm and relaxation while enhancing cognitive clarity and focus. Its potential to reduce anxiety and stress can contribute to an overall feeling of well-being, which is beneficial for those managing a brain disorder. By supporting cognitive function, Bacopa monnieri may offer additional help to individuals dealing with a brain disorder. Its calming effects might also aid in mitigating symptoms associated with a brain disorder, thus improving overall quality of life.

How does bacopa work in the brain?

Bacopa works in the brain by promoting neuroplasticity, enhancing synaptic communication, and protecting neurons from oxidative stress. Clinical trials have shown that it may also modulate neurotransmitter levels, including acetylcholine, serotonin, and dopamine, supporting cognitive function and mood. The ongoing clinical trial research continues to explore Bacopa’s potential benefits in these areas.

What are the functions of Bacopa?

The primary functions of Bacopa include enhancing cognitive function, improving memory, reducing anxiety, supporting brain health, and providing neuroprotective and antioxidant benefits. Evid based complement alternat research supports Bacopa’s role in these areas, including its potential impact on alleviating depression symptoms. Additionally, evid based complement alternat practices often recommend Bacopa for its potential cognitive benefits and its ability to help manage depression symptoms. Its use is backed by evid based complement alternat approaches for optimizing brain health and addressing depression symptoms.

Is bacopa a vasodilator?

Bacopa monniera linn may have mild vasodilatory effects, potentially helping to relax blood vessels and improve blood flow to the prefrontal cortex. This property, based on complement alternative medicine, can be beneficial for overall cardiovascular health and potentially enhance function in the prefrontal cortex. Additionally, based on complement alternative medicine, Bacopa monniera linn’s effects on blood flow could contribute to a healthier circulatory system, including better perfusion to the prefrontal cortex. If you’re exploring complement alternative medicine options for cardiovascular support, Bacopa monniera linn might be a helpful addition to your routine.

Does Bacopa effect acetylcholine?

Yes, water hyssop, a popular herbal supplement, is believed to influence acetylcholine levels, a key neurotransmitter involved in memory and learning. By modulating acetylcholine, this herbal supplement may enhance cognitive function and support memory processes. Water hyssop, also known as Bacopa, is thought to have these beneficial effects due to its impact on acetylcholine.

Is bacopa good for schizophrenia?

Bacopa may offer benefits for schizophrenia by enhancing cognitive function and potentially reducing anxiety, according to some human studies. In particular, research on the bacopa group shows promise, but human studies suggest it should not be used as a primary treatment. Instead, the bacopa group should be considered an adjunct to conventional therapies under medical supervision, as more human studies are needed to fully understand its effects. Continued investigation into the bacopa group could help clarify its role in supporting schizophrenia treatment.

Is bacopa an antipsychotic?

Bacopa is not classified as an antipsychotic. While it may have some beneficial effects on cognitive function and anxiety, it is not a substitute for conventional antipsychotics. An animal study may provide insights into its potential benefits, including its role in reducing oxidative stress and lipid peroxidation, but Bacopa’s efficacy in treating psychosis is not established through animal study alone. Further research on mechanisms like lipid peroxidation and clinical trials are needed beyond animal studies to fully understand its effects. Understanding how Bacopa affects lipid peroxidation could be key in evaluating its therapeutic potential.

Reference

Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707–713. doi:10.1089/acm.2008.0018.

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial

This study found that Bacopa monnieri extract improved memory recall and reduced anxiety and depression in healthy elderly participants over 12 weeks, compared to a placebo. The extract was well-tolerated with few adverse effects, primarily mild stomach upset. The findings suggest Bacopa’s potential for enhancing cognitive performance in aging individuals.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/.
Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012;18(7):647-52.

The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials

This systematic review found that Bacopa monnieri has some evidence of improving memory recall in adults without cognitive impairment, based on six randomized controlled trials. However, evidence for enhancement in other cognitive domains is limited, potentially due to inconsistent testing methods. More research is needed to explore Bacopa’s broader cognitive effects and its impact at varied dosages.

You can read the abstrct of the article at https://www.liebertpub.com/doi/10.1089/acm.2011.0367?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed.
Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002;27(2):279-81.

Chronic effects of Brahmi (Bacopa monnieri) on human memory

This study found that Brahmi (Bacopa monnieri) significantly improved retention of new information in adults aged 40-65, without affecting the rate of learning, attention, short-term memory, or retrieval of prior knowledge. Anxiety levels and everyday memory function were also unaffected.

You can read the full article at https://www.nature.com/articles/1395862.
Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med. 2010;16(7):753-9.

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial

This study found that Bacopa monnieri significantly improved memory acquisition and retention in healthy older adults, as measured by verbal learning and delayed recall tests. However, it caused gastrointestinal side effects like increased stool frequency, abdominal cramps, and nausea.

You can read the abstract of the article at https://www.liebertpub.com/doi/10.1089/acm.2009.0342?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed.
Stough CK, Pase MP, Cropley V, et al. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr J. 2012;11:11.

A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910)

The ARC Longevity Intervention (ARCLI) is a large-scale, randomized, placebo-controlled trial involving 465 participants to assess the effects of Bacopa monnieri and Pycnogenol on cognitive performance and brain health in older adults over 12 months. Participants will undergo various cognitive, neuropsychological, and biochemical assessments to explore potential enhancements in cognition and related mechanisms. This study aims to provide insights into nutritional and pharmacological strategies for mitigating age-related cognitive decline.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310777/.
Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707–713. doi:10.1089/acm.2008.0018.

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial

A 12-week randomized, double-blind, placebo-controlled trial found that Bacopa monnieri significantly improved delayed word recall and reduced anxiety and heart rate in healthy elderly participants, with few adverse effects. This supports Bacopa’s potential to enhance cognitive performance in aging.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/.
Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707-13.

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial

AA 12-week double-blind, placebo-controlled trial found that Bacopa monnieri significantly improved memory recall and reduced anxiety and heart rate in healthy elderly participants, with minimal side effects, supporting its potential to enhance cognitive function in aging.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/.
Stough C, Downey LA, Lloyd J, et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008;22(12):1629-34.

Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial

A 90-day double-blind, placebo-controlled study involving 107 healthy participants found that Bacopa monnieri significantly improved working memory and reduced false positives in a cognitive task, supporting its cognitive-enhancing effects. Further research is needed to determine optimal dosage and long-term effects.

You can read the full article at https://onlinelibrary.wiley.com/doi/10.1002/ptr.253.
Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med. 2010;16(7):753-9.

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial

A randomized, double-blind trial with 98 healthy older adults found that Bacopa monnieri significantly improved verbal learning, memory acquisition, and delayed recall, but caused gastrointestinal side effects like increased stool frequency and nausea. This supports traditional claims of Bacopa’s cognitive benefits.

You can read the abstract of the article at https://www.liebertpub.com/doi/10.1089/acm.2009.0342?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed.
Raghav S, Singh H, Dalal PK, Srivastava JS, Asthana OP. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006;48(4):238-42.

Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment

A double-blind, placebo-controlled study found that standardized Bacopa monniera extract (SBME) significantly improved mental control, logical memory, and paired associate learning in subjects with age-associated memory impairment (AAMI) after 12 weeks of treatment, suggesting its efficacy in enhancing cognitive function.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915594/.
Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001;156(4):481-4.

The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects

A double-blind, placebo-controlled study found that Bacopa monniera extract (300 mg) significantly improved visual information processing speed, learning rate, memory consolidation, and reduced state anxiety in healthy humans, with maximal effects observed after 12 weeks of treatment.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s002130100815.
Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013;16(4):313–326. doi:10.1089/rej.2013.1431.

Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res

This review highlights the cognitive-enhancing effects of Bacopa monnieri (BM), an Ayurvedic herb known for its memory-boosting properties. Research, including animal studies and clinical trials, supports BM’s potential in improving cognitive function and reducing risks for dementia, Parkinson’s disease, and epilepsy. BM likely works through antioxidant neuroprotection, enzyme modulation, acetylcholinesterase inhibition, and neurotransmitter regulation. While it shows low toxicity in both animals and humans, long-term human safety studies are still needed.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/.
Charles PD, Ambigapathy G, Geraldine P, Akbarsha MA, Rajan KE. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. J Ethnopharmacol. 2011;134(1):55-61.

Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation

This study investigated the effects of Bacopa monniera leaf ethanolic extract (BMEE) on learning, memory, and the serotonergic system in postnatal rats. BMEE significantly improved learning and memory retention, increased serotonin levels, and altered neurotransmitter activity, particularly elevating serotonin (5-HT) and decreasing dopamine (DA). The changes in serotonin were linked to increased expression of the enzyme TPH2 and the serotonin transporter, suggesting BMEE enhances cognitive function through serotonin regulation.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0378874110008305?via%3Dihub.
Available from https://www.sciencedirect.com/science/article/pii/S1558787809003402.

Effect of Bacopa monniera Linn. (brahmi) extract on learning and memory in rats: A behavioral study

This study explored the effects of different doses and durations of Bacopa monniera (BM) extract on Wistar rats’ behavior, focusing on learning and memory. Rats were given 20 mg/kg, 40 mg/kg, or 80 mg/kg of BM extract for 2, 4, or 6 weeks and tested on spatial learning and memory retention. The results showed that BM extract improved learning and memory, with enhanced performance in spatial learning and memory retention tasks.

You can read the full article at https://www.sciencedirect.com/science/article/pii/S1558787809003402.
Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol. 2010;127(1):26-31.

Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model

This study evaluated the effects of Bacopa monnieri extract on cognitive function and neurodegeneration in an Alzheimer’s disease animal model. Wistar rats were given Bacopa extract before and after the induction of Alzheimer’s using AF64A. The results showed improved spatial memory and reduced neuron and cholinergic neuron loss, suggesting Bacopa monnieri’s potential as a cognitive enhancer and neuroprotectant against Alzheimer’s disease.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0378874109006163?via%3Dihub.
Saraf MK, Prabhakar S, Khanduja KL, Anand A. Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice. Evid Based Complement Alternat Med. 2011;2011:236186.

Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice

This study explored Bacopa monniera’s ability to reverse scopolamine-induced amnesia in mice using a Morris water maze. Scopolamine significantly impaired memory acquisition and retrieval, causing both anterograde and retrograde amnesia. Bacopa monniera extract successfully reversed these effects, suggesting its potential as a treatment for Alzheimer’s disease through its impact on the cholinergic system.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095476/.
Saraf MK, Prabhakar S, Pandhi P, Anand A. Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral-molecular partitioning. Neuroscience. 2008;155(2):476-84.

Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral-molecular partitioning

This study investigated Bacopa monniera’s ability to reverse diazepam-induced amnesia in mice, focusing on long-term potentiation (LTP) molecules. Bacopa monniera significantly improved memory in the Morris water maze test and counteracted diazepam-induced changes in key molecular pathways, including MAP kinase and pCREB. While the herb reversed memory impairment, the precise molecular mechanisms remain unclear, though it appears to involve certain LTP-related molecules.

You can read the full article at https://www.ibroneuroscience.org/article/S0306-4522(8)00871-3/fulltext.
Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV. Neuroprotective mechanisms of ayurvedicantidementia botanical Bacopa monniera. Phytother Res. 2007;21(10):965-9.

Neuroprotective mechanisms of ayurvedicantidementia botanical Bacopa monniera

Bacopa monniera, traditionally used for cognitive enhancement, shows potential anti-Alzheimer’s properties by reducing beta-amyloid deposits in an Alzheimer’s disease animal model. This study found that Bacopa monniera extract contains polyphenols and sulfhydryl groups with antioxidant activity, which reduces divalent metals, scavenges reactive oxygen species, inhibits lipid peroxidation, and decreases lipoxygenase activity. These effects, combined with its ability to lower beta-amyloid levels, suggest mechanisms that may support Alzheimer’s disease treatment.

You can read the abstract of the article at https://onlinelibrary.wiley.com/doi/10.1002/ptr.2195.
Benson S, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res. 2014;28(4):551-9.

An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood

This double-blind, placebo-controlled study explored the acute cognitive, mood, and stress-reducing effects of Bacopa monnieri (BM) in healthy participants. After consuming BM extract (KeenMind® – CDRI 08), participants showed improved cognitive performance, especially on tasks like the Letter Search and Stroop test, within 1 to 2 hours. Positive mood changes and reduced cortisol levels suggested BM’s potential adaptogenic and stress-reducing properties. Further research is needed to confirm these findings in larger samples.

You can read the abstract of the article at https://onlinelibrary.wiley.com/doi/10.1002/ptr.5029.
Sathyanarayanan V, Thomas T, Einöther SJ, Dobriyal R, Joshi MK, Krishnamachari S. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults. Psychopharmacology (Berl). 2013;227(2):299-306.

Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults

This study examined the chronic effects of Bacopa monnieri (450 mg daily for 12 weeks) on cognitive function and anxiety in healthy adults. While no significant cognitive improvements were observed, there was a trend toward lower state anxiety in the Bacopa group compared to placebo. The findings differ from some previous studies, which reported cognitive enhancements and anxiety reduction.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s00213-013-2978-z.
Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707-13.

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial

This randomized, double-blind, placebo-controlled trial evaluated the effects of Bacopa monnieri extract (300 mg/day for 12 weeks) on cognitive function and mood in healthy elderly participants. Bacopa improved delayed word recall memory and performance on the Stroop Task compared to placebo, while reducing depression, anxiety, and heart rate. The extract was well tolerated with few adverse events, mainly mild stomach upset. This study supports Bacopa’s potential to enhance cognitive performance in aging adults.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/.
Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001;156(4):481-4.

The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects

This double-blind, placebo-controlled study examined the effects of Bacopa monniera (300 mg) on cognitive function in healthy adults. After 12 weeks, Bacopa significantly improved visual information processing, learning rate, memory consolidation, and reduced state anxiety compared to placebo. These results suggest Bacopa may enhance higher-order cognitive processes such as learning and memory.

You can read the full article at https://link.springer.com/article/10.1007/s002130100815.
Rai D, Bhatia G, Palit G, Pal R, Singh S, Singh HK. Adaptogenic effect of Bacopa monniera (Brahmi). PharmacolBiochemBehav. 2003;75(4):823-30.

Adaptogenic effect of Bacopa monniera (Brahmi)

This study investigated the adaptogenic effects of Bacopa monniera extract in rats exposed to acute and chronic stress. Bacopa significantly reduced stress-induced changes such as increased ulcer index, adrenal gland weight, and elevated biochemical markers (glucose, AST, ALT, and CK). Higher doses were more effective in reversing these stress-related changes, similar to Panax root powder. The findings suggest Bacopa monniera has potent adaptogenic properties.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0091305703001564?via%3Dihub.
Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytomedicine. 1998;5(2):77-82.

Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study

Bacopa monniera (BM), traditionally used in Ayurveda as a nervine tonic to improve memory and intellect, was tested for its anxiolytic effects in rats using various anxiety models. BM, administered at doses of 5, 10, and 20 mg/kg, showed dose-dependent anxiolytic activity comparable to lorazepam but without causing motor deficits. Higher doses of BM produced statistically significant results, and unlike benzodiazepines, BM also promotes cognition rather than causing amnesia, aligning with its Ayurvedic use for mental health.

You can read the abstract of the article at https://www.sciencedirect.com/science/article/abs/pii/S0944711398800019?via%3Dihub.
Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707-13.

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial

This randomized, double-blind, placebo-controlled study evaluated the effects of Bacopa monnieri (300 mg/day) on cognitive function and affect in 54 healthy elderly participants over 12 weeks. Bacopa improved delayed word recall and cognitive performance in the Stroop task, with reduced anxiety and heart rate compared to placebo. The extract was well tolerated, with mild adverse events like stomach upset, suggesting Bacopa monnieri may enhance cognitive performance in aging populations.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/.
Nemetchek MD, Stierle AA, Stierle DB, Lurie DI. The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. J Ethnopharmacol. 2016;197:92–100. doi:10.1016/j.jep.2016.07.073.

The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain

Bacopa monnieri, a medicinal plant used in Ayurveda as a nootropic, has been traditionally employed to treat memory loss, anxiety, and inflammation. This study investigated Bacopa’s anti-inflammatory effects in the brain, specifically its ability to inhibit the release of pro-inflammatory cytokines (TNF-α and IL-6) from microglial cells. Various Bacopa extracts also inhibited inflammatory enzymes like caspase-1, caspase-3, and matrix metalloproteinase-3, suggesting its potential as a therapeutic agent for CNS disorders by reducing brain inflammation.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269610/.
Sairam K, Dorababu M, Goel RK, Bhattacharya SK. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine. 2002;9(3):207-11.

Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats

Bacopa monniera, an Ayurvedic herb known for its cognitive and anxiolytic benefits, was investigated for its antidepressant effects in rodent models. A standardized methanolic extract of Bacopa (bacoside A content 38%) demonstrated significant antidepressant activity at doses of 20 and 40 mg/kg, comparable to the standard antidepressant imipramine, in forced swim and learned helplessness tests.

You can read the abstract of the article at https://www.sciencedirect.com/science/article/abs/pii/S0944711304701038?via%3Dihub.
Mannan A, Abir AB, Rahman R. Antidepressant-like effects of methanolic extract of Bacopa monniera in mice. BMC Complement Altern Med. 2015;15:337. Published 2015 Sep 25. doi:10.1186/s12906-015-0866-2.

Antidepressant-like effects of methanolic extract of Bacopa monniera in mice

This study evaluated the antidepressant-like effects of a methanolic extract of Bacopa monniera (MEBM) in mice using behavioral tests such as the forced swimming test, tail suspension test, and locomotor activity test. Results showed that MEBM significantly reduced immobility times in a dose-dependent manner, indicating strong antidepressant-like activity, while also increasing locomotion. These findings suggest that Bacopa monniera possesses antidepressant potential and warrants further investigation into its active compounds.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC458293.
Kumar S, Mondal AC. Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat. Neurochem Res. 2016;41(11):3083-3094.

Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat

This study investigated the neuroprotective, neurotrophic, and antioxidant effects of Bacopa monnieri extract (BME) on chronic stress-induced depression in rats. BME treatment significantly reduced depressive behaviors, normalized stress hormone levels (ACTH and corticosterone), and increased the expression of neurotrophic factors like BDNF and markers of hippocampal neurogenesis. Additionally, BME enhanced antioxidant enzyme activity, suggesting its potential role in mitigating depression by promoting neurogenesis and reducing oxidative stress.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s11064-016-2029-3.
Shen, Y.-H., Zhou, Y., Zhang, C., Liu, R.-H., Su, J., Liu, X.-H., et al. (2009). Antidepressant effects of methanol extract and fractions of bacopa monnieri. Pharm. Biol. 47, 340–343. doi: 10.1080/13880200902752694.

Antidepressant effects of methanol extract and fractions of bacopa monnieri

This study evaluated the antidepressant effects of Bacopa monniera methanol extract and its fractions in mice using the forced swimming test (FST) and tail suspension test (TST). The methanol extract, EtOAc fraction, and n-BuOH fraction significantly reduced immobility times, indicating antidepressant activity, without affecting locomotor activity after five days of oral administration.

You can read the full article at https://www.tandfonline.com/doi/full/10.1080/13880200902752694#d1e173.
Shahid M, Subhan F, Ahmad N, Ullah I. A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats. BMC Complement Altern Med. 2017;17(1):293. Published 2017 Jun 5. doi:10.1186/s12906-017-1807-z.

A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats

This study investigated the potential of Bacopa monnieri as an adjuvant therapy for neuropathic pain in a rat model of chronic constriction injury (CCI). The extract significantly reduced allodynia and hyperalgesia, improving pain thresholds and mimicking the effects of gabapentin, though to a lesser extent. These findings suggest Bacopa monnieri may help manage neuropathic pain alongside conventional treatments.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460461/.
Banerjee, R., Hazra, S., Ghosh, A. K., and Mondal, A. C. (2014). Chronic administration of bacopamonniera increases bdnf protein and mrna expressions: a study in chronic unpredictable stress induced animal model of depression. Psychiatry Invest. 11, 297–306. doi: 10.4306/pi.2014.11.3.297.

Chronic administration of bacopamonniera increases bdnf protein and mrna expressions: a study in chronic unpredictable stress induced animal model of depression

This study found that graded doses of Bacopa monnieri (BM) extract significantly alleviated depression-like behavior in rats subjected to chronic unpredictable stress (CUS). BM treatment improved sucrose consumption, locomotor activity, and escape behavior while also reversing CUS-induced reductions in brain-derived neurotrophic factor (BDNF) protein and mRNA levels in the hippocampus and frontal cortex. Doses of 80-120 mg/kg were particularly effective in producing antidepressant-like effects.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124189/.
Rauf, K., Subhan, F., Abbas, M., ulHaq, I., Ali, G., and Ayaz, M. (2012b). Effect of acute and sub chronic use of Bacopa monnieri on dopamine and serotonin turnover in mice whole brain. Afr. J. Pharm. Pharmacol. 6, 2767–2774. doi: 10.5897/AJPP12.244.

Effect of acute and sub chronic use of Bacopa monnieri on dopamine and serotonin turnover in mice whole brain

This study investigated the effects of acute and sub-chronic administration of Bacopa monnieri (BM) methanolic extract on dopamine (DA) and serotonin (5-HT) turnover in mice brains. Using HPLC analysis, it was found that both short-term and one-week treatments of BM at varying doses did not significantly affect DA or 5-HT levels, suggesting that BM does not alter these neurotransmitters and is safe in terms of not predisposing to neuropsychiatric problems related to DA and 5-HT modulation. Further studies are needed to explore BM’s effects on specific brain regions.

You can read the abstract of the article at https://www.researchgate.net/publication/232716761_Effect_of_acute_and_sub_chronic_use_of_Bacopa_monnieri_on_dopamine_and_serotonin_turnover_in_mice_whole_brain.
Available from https://www.semanticscholar.org/paper/Effect-of-bacosides-enriched-standardized-extract-a-Kala-Kumar/ea5fc77385266880706c4e48bfe0ec3b859e4a21.
Kamkaew N, Scholfield CN, Ingkaninan K, et al. Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types. J Ethnopharmacol. 2011;137(1):790-5.

Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types

This study found that Bacopa monnieri (Brahmi) extract lowers blood pressure in rats without affecting heart rate and relaxes arteries by promoting nitric oxide release from the endothelium and affecting calcium regulation in vascular smooth muscles. These actions suggest potential antihypertensive effects, contributing to its traditional medicinal use.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0378874111004740?via%3.
Sireeratawong S, Jaijoy K, Khonsung P, Lertprasertsuk N, Ingkaninan K. Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats. BMC Complement Altern Med. 2016;16:249. Published 2016 Jul 27. doi:10.1186/s12906-016-1236-4.

Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

The study found that Bacopa monnieri extract, administered at both acute (5,000 mg/kg) and chronic (up to 1,500 mg/kg for 270 days) doses, did not cause any significant toxicity in rats, as indicated by normal hematological, biochemical, and histopathological parameters, as well as normal behavior and health.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962406/.
Kumar EP, Elshurafa AA, Elango K, Subburaju T, Suresh B. Cytotoxic and anti -tumour properties of ethanolic extract of bacopa monnieri (L) penn.AncSci Life. 1998;17(3):228-34.

Cytotoxic and anti -tumour properties of ethanolic extract of bacopa monnieri (L) penn

The study found that the ethanolic extract of Bacopa monnieri (EEMB) significantly inhibited the proliferation of cancer cells in a dose-dependent manner and reduced solid tumor growth in an animal model, while also normalizing altered hematological parameters.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331112/pdf/ASL-17-228.pdf.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331112/pdf/ASL-17-228.pdf.

Cytotoxic and anti -tumour properties of ethanolic extract of bacopa monnieri (L) penn

The study found that the ethanolic extract of Bacopa monnieri (EEMB) significantly inhibited the proliferation of cancer cells in a dose-dependent manner and reduced solid tumor growth in an animal model, while also normalizing altered hematological parameters.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331112/pdf/ASL-17-228.pdf.
Rohini G, Devi CS. Bacopa monniera extract induces apoptosis in murine sarcoma cells (S-180). Phytother Res. 2008;22(12):1595-8.

Bacopa monniera extract induces apoptosis in murine sarcoma cells (S-180)

Bacopa monnieri (BM) induces dose- and time-dependent cytotoxicity in S-180 tumor cells, with maximum effect at 48 hours at a concentration of 550 µg/ml. Transmission electron microscopy and Annexin V-FITC assay confirmed that BM triggers apoptosis, while glutathione levels decreased in treated cells, supporting BM’s potential as an anticancer agent.

You can read the abstract of the article at https://onlinelibrary.wiley.com/doi/10.1002/ptr.2515.
Peng L, Zhou Y, Kong de Y, Zhang WD. Antitumor activities of dammaranetriterpenesaponins from Bacopa monniera. Phytother Res. 2010;24(6):864-8.

Antitumor activities of dammaranetriterpenesaponins from Bacopa monniera

The methanol extract of Bacopa monnieri and its n-BuOH fraction showed significant antitumor activity, particularly the isolated compounds bacopaside E and bacopaside VII. These compounds demonstrated strong cytotoxicity against multiple human tumor cell lines and significantly inhibited tumor growth and cancer cell behaviors in vitro and in vivo, warranting further investigation into their mechanisms.

You can read the abstract of the article at https://onlinelibrary.wiley.com/doi/10.1002/ptr.3034.
Available from http://ijpsr.com/bft-article/in-vitro-anticancer-activity-and-phytochemical-analysis-of-bacopa-monnieri-l-wettst/?view=fulltext.

IN VITRO ANTICANCER ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF BACOPA MONNIERI (L.) WETTST.

Bacopa monnieri (BM) has been traditionally used for various ailments and was found to possess anticancer properties in vitro, particularly against human breast cancer cell line MDA-MB-468. Phytochemical analysis revealed that BM contains compounds such as saponins and flavonoids, which may contribute to its anticancer activity.

You can read the abstract of the article at http://ijpsr.com/bft-article/in-vitro-anticancer-activity-and-phytochemical-analysis-of-bacopa-monnieri-l-wettst/?view=fulltext.
Mallick MN, Akhtar MS, Najm MZ, Tamboli ET, Ahmad S, Husain SA. Evaluation of anticancer potential of Bacopa monnieri L. against MCF-7 and MDA-MB 231 cell line. J Pharm Bioallied Sci. 2015;7(4):325-8.

Evaluation of anticancer potential of Bacopa monnieri L. against MCF-7 and MDA-MB 231 cell line

The ethanolic extract of Bacopa monnieri (BM), particularly its dichloromethane (DCM) fraction, showed significant in vitro cytotoxic activity against MCF-7 and MDA-MB 231 breast cancer cell lines. This effect may be attributed to the presence of cucurbitacins and betulinic acid, which are known for their anti-tumorigenic properties.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678980/.
Smith E, Palethorpe HM, Tomita Y, et al. The Purified Extract from the Medicinal Plant, y6Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis. Cells. 2018;7(7).

The Purified Extract from the Medicinal Plant, y6Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis

Bacopaside II, a compound from Bacopa monnieri, inhibits colon cancer cell growth by blocking the AQP1 water channel. It induces cell cycle arrest and apoptosis in HT-29, SW480, SW620, and HCT116 colon cancer cells, showing potential as an anti-tumor agent.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070819/.
John S, Sivakumar KC, Mishra R. Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis. Front MolNeurosci. 2017;10:171.

Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis

Bacopa monnieri (BM) and its bioactive component, Bacoside A, induce tumor-specific disturbances in glioblastoma cells by disrupting hydrostatic pressure balance, leading to non-apoptotic cell death. This mechanism involves calcium release and cell swelling, offering a potential safe therapeutic approach for treating glioblastoma multiforme.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471305/.
Available from http://www.indianjournals.com/ijor.aspx?target=ijor:rjpt&volume=6&issue=4&article=011.
https://www.ncbi.nlm.nih.gov/pubmed/19916024Janani P, Sivakumari K, Geetha A, Ravisankar B, Parthasarathy C. Chemopreventive effect of bacosideA on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. J Cancer Res ClinOncol. 2010;136(5):759-70.

Chemopreventive effect of bacosideA on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

Bacoside A, an active compound of Bacopa monnieri, shows chemopreventive effects against N-nitrosodiethylamine-induced liver cancer in an animal model by reducing lipid peroxidation, restoring antioxidant levels, and protecting liver tissue from damage, supporting its potential as a protective agent against hepatocarcinogenesis.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s00432-009-0715-0.
Kalyani MI, Lingaraju SM, Salimath BP. A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary carcinoma cells. J Nat Med. 2013;67(1):123-36.

A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary carcinoma cells

Bacopa monnieri water extract (BMWE) induces apoptosis in Ehrlich ascites tumor cells by activating the caspase-3 pathway and increasing the pro-apoptotic gene Bax while decreasing the anti-apoptotic gene Bcl-2, leading to DNA fragmentation and programmed cell death, highlighting its potential as an anticancer agent.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s11418-012-0661-z.
Available from http://ijpsr.com/bft-article/in-vitro-anticancer-activity-and-phytochemical-analysis-of-bacopa-monnieri-l-wettst/?view=fulltext.

IN VITRO ANTICANCER ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF BACOPA MONNIERI (L.) WETTST.

Bacopa monnieri, a herb used in Ayurvedic medicine, has shown diverse medicinal properties, including anticancer, antitumor, and antioxidative effects. Preliminary studies indicate that its ethanolic extract, rich in saponins and flavonoids, exhibited notable anticancer activity, particularly against human breast cancer cell line MDA-MB-468.

You can read the abstract of the article at http://ijpsr.com/bft-article/in-vitro-anticancer-activity-and-phytochemical-analysis-of-bacopa-monnieri-l-wettst/?view=fulltext.
Available from http://www.phytojournal.com/vol2Issue2/Issue_july_2013/40.1.pdf.
Bharali R, Azad MR, Tabassum J. Chemopreventive action of Boerhaaviadiffusa on DMBA-induced skin carcinogenesis in mice. Indian J PhysiolPharmacol. 2003;47(4):459-64.

Chemopreventive action of Boerhaaviadiffusa on DMBA-induced skin carcinogenesis in mice

Boerhaavia diffusa, traditionally used to treat jaundice, was studied for its cancer chemopreventive effects in mice with DMBA-induced skin papillomagenesis. The study showed that B. diffusa extract significantly reduced tumor incidence, average tumor numbers, and papilloma development, particularly when applied during both the peri- and post-initiational stages of tumor formation.

You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/15266960/.
Available from https://link.springer.com/article/10.1007/s13596-011-0001-y.
Kalyani MI, Lingaraju SM, Salimath BP. A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary carcinoma cells. J Nat Med. 2013;67(1):123-36.

A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary carcinoma cells

Bacopa monnieri water extract (BMWE) has demonstrated anticancer potential by inducing apoptosis in Ehrlich ascites tumor (EAT) cells. BMWE activates caspase-3, leading to DNA fragmentation through caspase-activated DNase (CAD) and increases pro-apoptotic gene Bax expression while decreasing anti-apoptotic gene Bcl-2. These findings suggest BMWE’s ability to trigger programmed cell death, positioning it as a potential therapeutic for cancer treatment.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s11418-012-0661-z.

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